Influenza antivirals currently in late-phase clinical trial.

abstract：BACKGROUND:Antibodies to neuraminidase (NA) contribute to protection during influenza virus infection, but NA inhibition (NI) titers are not routinely analyzed in vaccine trials. One reason is the cumbersome nature of the conventional thiobarbituric acid (TBA) NI assay, which uses chemical methods to quantify free sial...

journal_title：Influenza and other respiratory viruses

authors： Sandbulte MR,Gao J,Straight TM,Eichelberger MC

更新日期：2009-09-01 00:00:00

abstract：:Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we d...

journal_title：Influenza and other respiratory viruses

authors： Koszalka P,Farrukee R,Mifsud E,Vijaykrishna D,Hurt AC

更新日期：2020-07-01 00:00:00

abstract：:Highly pathogenic avian influenza A H5N1 viruses remain a significant health threat to humans given the continued rare occurrence of human cases with a high case fatality rate. This brief literature review summarizes available evidence of risk factors for H5N1 infection in humans and updates a recent systematic review...

journal_title：Influenza and other respiratory viruses

authors： Van Kerkhove MD

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Whether morbidity from the 1918-19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue, the recent literature has hypothesized that morbidity was "socially neutral." OBJECTIVES:To study the associations between influenz...

journal_title：Influenza and other respiratory viruses

authors： Mamelund SE

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Since 2004, H5N1 outbreaks have been recurrent in domestic poultry and humans in Cambodia. To date, seven human cases (100% CFR) and 22 outbreaks in poultry have been confirmed. Household ownership of backyard poultry (FAO Sector 4 poultry production) in rural Cambodia is high. An understanding of the extent...

journal_title：Influenza and other respiratory viruses

authors： Van Kerkhove MD,Ly S,Holl D,Guitian J,Mangtani P,Ghani AC,Vong S

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The new influenza virus A/H1N1 (2009), identified in mid-2009, rapidly spread over the world. Estimating the transmissibility of this new virus was a public health priority. METHODS:We reviewed all studies presenting estimates of the serial interval or generation time and the reproduction number of the A/H1...

journal_title：Influenza and other respiratory viruses

authors： Boëlle PY,Ansart S,Cori A,Valleron AJ

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Given their medical vulnerabilities, we investigated the epidemiological factors related to H1N1 infection in school-aged children. METHODS:This study analyzed data collected on 7448 school-aged children in South Korea between 18 November and 8 December 2009. RESULTS:We found that H1N1 infection was associa...

journal_title：Influenza and other respiratory viruses

authors： Kim CO,Nam CM,Lee DC,Chang J,Lee JW

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:School-located influenza vaccination (SLV) programs have the potential to mass-vaccinate all enrolled children, but parental consent is required. OBJECTIVE:To examine parental attitudes and determine predictors of parental consent for vaccination of schoolchildren through SLV programs. PATIENTS/METHODS:Sur...

journal_title：Influenza and other respiratory viruses

authors： Cheung S,Wang HL,Mascola L,El Amin AN,Pannaraj PS

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The relative ability of neuraminidase inhibitors (NAIs) to reduce household influenza transmission when given to index patients is not established. OBJECTIVES:To compare daily secondary infection rates (SIR) of influenza A (A/H1pdm and A/H3) and B in households of index patients treated with oseltamivir, za...

journal_title：Influenza and other respiratory viruses

authors： Hirotsu N,Saisho Y,Hasegawa T

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:A point-of-care rapid test (POCRT) may help early and targeted use of antiviral drugs for the management of influenza A infection. OBJECTIVE:(i) To determine whether antiviral treatment based on a POCRT for influenza A is cost-effective and, (ii) to determine the thresholds of key test parameters (sensitivi...

journal_title：Influenza and other respiratory viruses

authors： Nshimyumukiza L,Douville X,Fournier D,Duplantie J,Daher RK,Charlebois I,Longtin J,Papenburg J,Guay M,Boissinot M,Bergeron MG,Boudreau D,Gagné C,Rousseau F,Reinharz D

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In this study we investigated the levels of cytokines and chemokines produced locally and systemically after influenza vaccination of patients undergoing tonsillectomy. METHODS:Blood and saliva were collected prior to, and 1 or 2 weeks after vaccination at the time of the tonsillectomy. The cy...

journal_title：Influenza and other respiratory viruses

authors： Eriksson JC,Cox RJ,Szyszko E,Davidsson A,Brokstad KA

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:At the onset of the pandemic H1N1/09 influenza A outbreak in Australia, health authorities devised official clinical case definitions to guide testing and access to antiviral therapy. OBJECTIVES:To assess the diagnostic accuracy of these case definitions and to attempt to improve on them using a scoring sys...

journal_title：Influenza and other respiratory viruses

authors： Mahony AA,Cheng AC,Olsen KL,Aboltins CA,Black JF,Johnson PD,Lindsay Grayson M,Torresi J

更新日期：2013-05-01 00:00:00

abstract：:When the influenza A (H1N1) pandemic spread across the globe from April 2009 to August 2010, many WHO Member States used antiviral drugs, specifically neuraminidase inhibitors (NAIs) oseltamivir and zanamivir, to treat influenza patients in critical condition. Antivirals have been found to be effective in reducing sev...

journal_title：Influenza and other respiratory viruses

authors： Miller PE,Rambachan A,Hubbard RJ,Li J,Meyer AE,Stephens P,Mounts AW,Rolfes MA,Penn CR

更新日期：2013-09-01 00:00:00

abstract：:Antiviral drugs continue to be an important option for the treatment of influenza disease and will likely be the only option during the early phases of pandemic. However, the limited number of drug classes licensed for treatment of influenza raises several issues, particularly in the face of drug resistance. Two class...

journal_title：Influenza and other respiratory viruses

authors： Wathen MW,Barro M,Bright RA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Respiratory protective devices are critical in protecting against infection in healthcare workers at high risk of novel 2019 coronavirus disease (COVID-19); however, recommendations are conflicting and epidemiological data on their relative effectiveness against COVID-19 are limited. PURPOSE:To compare medi...

journal_title：Influenza and other respiratory viruses

authors： Bartoszko JJ,Farooqi MAM,Alhazzani W,Loeb M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Guillain-Barre syndrome (GBS) is a rare autoimmune disease characterized by acute, progressive peripheral neuropathy and is commonly associated with the presence of antiganglioside antibodies. Previously, influenza vaccination was linked with the increased incidence of GBS; however, whether antiganglioside a...

journal_title：Influenza and other respiratory viruses

authors： Wang DJ,Boltz DA,McElhaney J,McCullers JA,Webby RJ,Webster RG

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:In Ireland, horses may be protected against equine influenza virus (EIV) as a result of natural exposure or vaccination. Current mandatory vaccination programmes are targeted at highly mobile horses. A correlation between antibody levels as measured by single radial haemolysis (SRH) and protective immunity a...

journal_title：Influenza and other respiratory viruses

authors： Gildea S,Arkins S,Cullinane A

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Highly pathogenic H5N1 influenza viruses reemerged in humans in 2003 and have caused fatal human infections in Asia and Africa as well as ongoing outbreaks in poultry. These viruses have evolved substantially and are now so antigenically varied that a single vaccine antigen may not protect against all circul...

journal_title：Influenza and other respiratory viruses

authors： Ducatez MF,Webb A,Crumpton JC,Webby RJ

更新日期：2013-07-01 00:00:00

abstract：AIM:To determine factors associated with severe hospitalized Respiratory syncytial virus (RSV)-associated LRTI and to describe management in tertiary care center. METHODS:Retrospective medical record review was conducted among children under 5 years old hospitalized with RSV-associated LRTI at King Chulalongkorn Memor...

journal_title：Influenza and other respiratory viruses

authors： Aikphaibul P,Theerawit T,Sophonphan J,Wacharachaisurapol N,Jitrungruengnij N,Puthanakit T

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Influenza vaccine coverage rates among healthcare workers (HCWs) in acute care facilities in Canada remain below national targets. OBJECTIVE:To determine factors associated with influenza vaccine uptake among HCWs. METHODS:This secondary analysis of a prospective cohort study included HCWs aged 18-69 years...

journal_title：Influenza and other respiratory viruses

authors： Hussain H,McGeer A,McNeil S,Katz K,Loeb M,Simor A,Powis J,Langley J,Muller M,Canadian Health Care Worker Study Group.,Coleman BL

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Nineteen mass vaccination clinics were established in Montreal, Canada, as part of the 2009 influenza A/H1N1p vaccination campaign. Although approximately 50% of the population was vaccinated, there was a considerable variation in clinic performance and community vaccine coverage. OBJECTIVE:To identify comm...

journal_title：Influenza and other respiratory viruses

authors： Charland KM,de Montigny L,Brownstein JS,Buckeridge DL

更新日期：2014-05-01 00:00:00

abstract：:The emergence of a novel swine-origin pandemic influenza virus in 2009, together with the continuing circulation of highly pathogenic avian H5N1 viruses and the urgent global need to produce effective vaccines against such public health threats, has prompted a renewed interest in improving our understanding of the imm...

journal_title：Influenza and other respiratory viruses

authors： Haaheim LR,Katz JM

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Fever and respiratory symptoms are the major causes of hospitalisation in infants aged 90 days or less. Respiratory viruses (RVs) are detected by multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) in up to 70% of infants tested in this population. Aminotransferase elevation is not uncommon i...

journal_title：Influenza and other respiratory viruses

authors： Kim SG,Oh YN,Lee JK

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Reviews of the global response to the 2009 pandemic of influenza A/H1N1 affirmed the importance of assessment of preparedness and response capabilities. DESIGN:The U. S. Centers for Disease Control and Prevention (CDC) and partners developed the National Inventory of Core Capabilities for Pandemic Influenza...

journal_title：Influenza and other respiratory viruses

authors： MacDonald G,Moen AC,St Louis ME

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The Northern Territory (NT) of Australia has a mix of climates, sparsely distributed population and a large proportion of the populace are Indigenous Australians, and influenza is known to have a disproportionate impact upon this group. Understanding the epidemiology of influenza in this region would inform ...

journal_title：Influenza and other respiratory viruses

authors： Weinman AL,Sullivan SG,Vijaykrishna D,Markey P,Levy A,Miller A,Tong SYC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Molecular testing for viral pathogens has resulted in increasing detection of multiple viruses in respiratory secretions of ill children. The clinical impact of multiple virus infections on clinical presentation and outcome is unclear. OBJECTIVES:To compare clinical characteristics and viral load between ch...

journal_title：Influenza and other respiratory viruses

authors： Martin ET,Kuypers J,Wald A,Englund JA

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Knowledge of the secondary attack rate (SAR) and serial interval (SI) of influenza is important for assessing the severity of seasonal epidemics of the virus. To date, such estimates have required extensive surveys of target populations. Here, we propose a method for estimating the intrafamily SAR and SI fro...

journal_title：Influenza and other respiratory viruses

authors： Yom-Tov E,Johansson-Cox I,Lampos V,Hayward AC

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:To determined the pathogen-specific incidence of respiratory virus infection in Hutterite communities occurring over the 2008-2009 influenza season and assess temporal characteristics of respiratory illness related to infection. METHODS:3273 participants community members enrolled in a cluster randomized tr...

journal_title：Influenza and other respiratory viruses

authors： Kim TH,Russell ML,Fonseca K,Aoki F,Horsman G,Van Caeseele P,Chokani K,Voight M,Babiuk L,Moss L,Webby R,Earn DJ,Singh P,Howse C,Loeb M

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:We aimed to examine the efficacy of medical masks and respirators in protecting against respiratory infections using pooled data from two homogenous randomised control clinical trials (RCTs). METHODS:The data collected on 3591 subjects in two similar RCTs conducted in Beijing, China, which examined the same ...

journal_title：Influenza and other respiratory viruses

authors： MacIntyre CR,Chughtai AA,Rahman B,Peng Y,Zhang Y,Seale H,Wang X,Wang Q

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Influenza surveillance helps time prevention and control interventions especially where complex seasonal patterns exist. We assessed influenza surveillance sustainability in Africa where influenza activity varies and external funds for surveillance have decreased. METHODS:We surveyed African Network for Inf...

journal_title：Influenza and other respiratory viruses

authors： Igboh LS,McMorrow M,Tempia S,Emukule GO,Talla Nzussouo N,McCarron M,Williams T,Weatherspoon V,Moen A,Fawzi D,Njouom R,Nakoune E,Dauoda C,Kavunga-Membo H,Okeyo M,Heraud JM,Mambule IK,Sow SO,Tivane A,Lagare A,Adebay

更新日期：2020-11-04 00:00:00