Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model.

abstract：:Antiviral drugs continue to be an important option for the treatment of influenza disease and will likely be the only option during the early phases of pandemic. However, the limited number of drug classes licensed for treatment of influenza raises several issues, particularly in the face of drug resistance. Two class...

journal_title：Influenza and other respiratory viruses

authors： Wathen MW,Barro M,Bright RA

更新日期：2013-01-01 00:00:00

abstract：:Within a hand-washing clinical trial, we evaluated factors associated with fomite contamination in households with an influenza-infected child. Influenza virus RNA contamination was higher in households with low absolute humidity and in control households, suggesting that hand washing reduces surface contamination. ...

journal_title：Influenza and other respiratory viruses

authors： Levy JW,Suntarattiwong P,Simmerman JM,Jarman RG,Johnson K,Olsen SJ,Chotpitayasunondh T

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Hospitalization burden associated with influenza and respiratory syncytial virus (RSV) is uncertain due to ambiguity in the inference methodologies employed for its estimation. OBJECTIVES:Utilization of a new method to quantitate the above burden. METHODS:Weekly hospitalization rates for several principal ...

journal_title：Influenza and other respiratory viruses

authors： Goldstein E,Greene SK,Olson DR,Hanage WP,Lipsitch M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:A diversifying pool of mammalian-adapted influenza A viruses (IAV) with largely unknown zoonotic potential is maintained in domestic swine populations worldwide. The most recent human influenza pandemic in 2009 was caused by a virus with genes originating from IAV isolated from swine. Swine influenza viruses...

journal_title：Influenza and other respiratory viruses

authors： Henritzi D,Zhao N,Starick E,Simon G,Krog JS,Larsen LE,Reid SM,Brown IH,Chiapponi C,Foni E,Wacheck S,Schmid P,Beer M,Hoffmann B,Harder TC

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:A population-based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy. OBJECTIVES:We studied maternal A(H1N1)pdm09-specific hemagglutination inhibition (HI)-titer levels and waning in women with influenza-...

journal_title：Influenza and other respiratory viruses

authors： Tunheim G,Laake I,Robertson AH,Waalen K,Hungnes O,Naess LM,Cox RJ,Mjaaland S,Trogstad L

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The relative ability of neuraminidase inhibitors (NAIs) to reduce household influenza transmission when given to index patients is not established. OBJECTIVES:To compare daily secondary infection rates (SIR) of influenza A (A/H1pdm and A/H3) and B in households of index patients treated with oseltamivir, za...

journal_title：Influenza and other respiratory viruses

authors： Hirotsu N,Saisho Y,Hasegawa T

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Since 2009, Thailand has recommended influenza vaccine for children aged 6 months through 2 years, but no estimates of influenza vaccine coverage or effectiveness are available for this target group. METHODS:During August 2011-May 2013, high-risk and healthy children aged ≤36 months were enrolled in a 2-yea...

journal_title：Influenza and other respiratory viruses

authors： Kittikraisak W,Suntarattiwong P,Levy J,Fernandez S,Dawood FS,Olsen SJ,Chotpitayasunondh T

更新日期：2015-03-01 00:00:00

abstract：:Oseltamivir-resistant 2009 H1N1 influenza virus infections associated with neuraminidase (NA) H275Y have been identified sporadically. Strains possessing the hemagglutinin (HA) D222G mutation have been detected in small numbers of fatal 2009 H1N1 cases. We report the first clinical description of 2009 H1N1 virus infec...

journal_title：Influenza and other respiratory viruses

authors： DeVries A,Wotton J,Lees C,Boxrud D,Uyeki T,Lynfield R

更新日期：2012-11-01 00:00:00

abstract：:Enterovirus 68 (EV68) infection occasionally manifests with fatal outcomes. However, detection of EV68 in serum and its clinical outcomes are yet to be determined. In this study, we retrospectively tested stored serum samples collected from pediatric pneumonia patients whose nasopharyngeal specimens were positive for ...

journal_title：Influenza and other respiratory viruses

authors： Imamura T,Suzuki A,Lupisan S,Kamigaki T,Okamoto M,Roy CN,Olveda R,Oshitani H

更新日期：2014-01-01 00:00:00

abstract：:We conducted a retrospective cohort study to evaluate the impact of obesity on influenza disease severity. Individuals with obesity were more likely to have lower pulmonary disease manifestations [OR=1·97 (95% CI 1·05, 3·69), P=0·03] and to be admitted to an inpatient ward [OR=2·93 (95% CI 1·50, 5·71), P=0·002] when c...

journal_title：Influenza and other respiratory viruses

authors： Martin ET,Archer C,McRoberts J,Kulik J,Thurston T,Lephart P,Kaye KS

更新日期：2013-11-01 00:00:00

abstract：:Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we d...

journal_title：Influenza and other respiratory viruses

authors： Koszalka P,Farrukee R,Mifsud E,Vijaykrishna D,Hurt AC

更新日期：2020-07-01 00:00:00

abstract：:As the most important viral cause of severe respiratory disease in infants and increasing recognition as important in the elderly and immunocompromised, respiratory syncytial virus (RSV) is responsible for a massive health burden worldwide. Prophylactic antibodies were successfully developed against RSV. However, thei...

journal_title：Influenza and other respiratory viruses

authors： Broadbent L,Groves H,Shields MD,Power UF

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Despite the use of vaccines, low-pathogenic (LP) H5N2 influenza viruses have continued to circulate and evolve in chickens in Mexico since 1993, giving rise to multiple genetic variants. Antigenic drift is partially responsible for the failure to control H5N2 influenza by vaccination; the contribution of mat...

journal_title：Influenza and other respiratory viruses

authors： Forrest HL,Garcia A,Danner A,Seiler JP,Friedman K,Webster RG,Jones JC

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Highly pathogenic avian influenza A/H5N1 virus remains a potential pandemic threat, and it is essential to continue vaccine development against this subtype. A local mucosal immune response in the upper respiratory tract may stop influenza transmission. It is therefore important to develop effective intranas...

journal_title：Influenza and other respiratory viruses

authors： Svindland SC,Pedersen GK,Pathirana RD,Bredholt G,Nøstbakken JK,Jul-Larsen Å,Guzmán CA,Montomoli E,Lapini G,Piccirella S,Jabbal-Gill I,Hinchcliffe M,Cox RJ

更新日期：2013-11-01 00:00:00

abstract：:We report a whole-genome analysis of 19 influenza A(H1N1)pdm09 isolates from four Ugandan hospitals between 2009 and 2011. The isolates differed from the vaccine strain A/California/07/2009 by three amino acid substitutions P100S, S220T, and I338V in the hemagglutinin and by two amino acid substitutions V106I and N248...

journal_title：Influenza and other respiratory viruses

authors： Byarugaba DK,Erima B,Millard M,Kibuuka H,Lkwago L,Bwogi J,Mimbe D,Kiconco JB,Tugume T,Mworozi EA,Turner J,Mckenzie PP,Webby RR,Webster RG,Foret C,Ducatez MF,Coldren R,Wabwire-Mangen F,Krauss S

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:A wide range of methods have been used for estimating influenza-associated deaths in temperate countries. Direct comparisons of estimates produced by using different models with US mortality data have not been published. OBJECTIVE:Compare estimates of US influenza-associated deaths made by using four models...

journal_title：Influenza and other respiratory viruses

authors： Thompson WW,Weintraub E,Dhankhar P,Cheng PY,Brammer L,Meltzer MI,Bresee JS,Shay DK

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:Influenza-associated myositis (IAM), characterized by severe lower-extremity myalgia and reluctance to walk, is a complication of influenza among children. We investigated IAM in Nebraska during six influenza seasons, 2001-2007. METHODS:During 2006-2007, we requested reports of severe influenza illness among...

journal_title：Influenza and other respiratory viruses

authors： Buss BF,Shinde VM,Safranek TJ,Uyeki TM

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Whether morbidity from the 1918-19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue, the recent literature has hypothesized that morbidity was "socially neutral." OBJECTIVES:To study the associations between influenz...

journal_title：Influenza and other respiratory viruses

authors： Mamelund SE

更新日期：2018-05-01 00:00:00

abstract：:In the centenary year of the devastating 1918-19 pandemic, it seems opportune to reflect on the success of the WHO Global Influenza Surveillance and Response System (GISRS) initiated 70 years ago to provide early warning of changes in influenza viruses circulating in the global population to help mitigate the conseque...

journal_title：Influenza and other respiratory viruses

authors： Hay AJ,McCauley JW

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Given the sparse information on the burden of influenza in Lebanon, the Ministry of Public Health established a sentinel surveillance for severe acute respiratory infections (SARI) to identify the attribution of influenza to reported cases. We aim to highlight the proportion of influenza-associated SARI from...

journal_title：Influenza and other respiratory viruses

authors： Saleh M,Bazzi L,Ismail E,Mroueh L,Jammal N,Elkholy A,Mrad P,Samadi AA,Hijazi A,Abiad F,Nsouli G,Rady A,Khan W,Malik M,Zalloua P,Ammar W,Ghosn N

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In this study we investigated the levels of cytokines and chemokines produced locally and systemically after influenza vaccination of patients undergoing tonsillectomy. METHODS:Blood and saliva were collected prior to, and 1 or 2 weeks after vaccination at the time of the tonsillectomy. The cy...

journal_title：Influenza and other respiratory viruses

authors： Eriksson JC,Cox RJ,Szyszko E,Davidsson A,Brokstad KA

更新日期：2007-07-01 00:00:00

abstract：:This study used Poisson regression modelling to estimate influenza-associated mortality in New Zealand for 1990-2008. Inputs were weekly numbers of deaths and influenza and RSV isolates. Seasonal influenza was associated with an average of 401 medical deaths annually from 1990 to 2008, a rate of 10.6 (95% CI: 7.9, 13....

journal_title：Influenza and other respiratory viruses

authors： Kessaram T,Stanley J,Baker MG

更新日期：2015-01-01 00:00:00

abstract：:When the influenza A (H1N1) pandemic spread across the globe from April 2009 to August 2010, many WHO Member States used antiviral drugs, specifically neuraminidase inhibitors (NAIs) oseltamivir and zanamivir, to treat influenza patients in critical condition. Antivirals have been found to be effective in reducing sev...

journal_title：Influenza and other respiratory viruses

authors： Miller PE,Rambachan A,Hubbard RJ,Li J,Meyer AE,Stephens P,Mounts AW,Rolfes MA,Penn CR

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Antibodies to neuraminidase (NA) contribute to protection during influenza virus infection, but NA inhibition (NI) titers are not routinely analyzed in vaccine trials. One reason is the cumbersome nature of the conventional thiobarbituric acid (TBA) NI assay, which uses chemical methods to quantify free sial...

journal_title：Influenza and other respiratory viruses

authors： Sandbulte MR,Gao J,Straight TM,Eichelberger MC

更新日期：2009-09-01 00:00:00

abstract：:The ID Screen Influenza H5 Antibody Competition enzyme-linked immunosorbent assay was tested for the detection of antibodies to the H5 subtype of influenza A (IA) virus in waterfowl. Assays were conducted with sera obtained from Mallards (Anas platyrhynchos) and Pekin Ducks (Anas platyrhynchos domestica), experimental...

journal_title：Influenza and other respiratory viruses

authors： Lebarbenchon C,Pantin-Jackwood M,Kistler WM,Luttrell MP,Spackman E,Stallknecht DE,Brown JD

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The 2009 pandemic H1N1 (A(H1N1)pdm09) influenza A virus (IAV) has replaced the previous seasonal H1N1 strain in humans and continues to circulate worldwide. The comparative performance of inactivated A(H1N1)pdm09 influenza vaccines remains of considerable interest. The objective of this study was to evaluate...

journal_title：Influenza and other respiratory viruses

authors： Vidaña B,Brookes SM,Everett HE,Garcon F,Nuñez A,Engelhardt O,Major D,Hoschler K,Brown IH,Zambon M

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Influenza A(H3N2), A(H1N1)pdm09 and B viruses co-circulated in Europe in 2017-18, predominated by influenza B. WHO-recommended, trivalent vaccine components were lineage-mismatched for B. The I-MOVE hospital network measured 2017-18 seasonal influenza vaccine effectiveness (IVE) against influenza A(H3N2) and...

journal_title：Influenza and other respiratory viruses

authors： Rose AMC,Kissling E,Gherasim A,Casado I,Bella A,Launay O,Lazăr M,Marbus S,Kuliese M,Syrjänen R,Machado A,Kurečić Filipović S,Larrauri A,Castilla J,Alfonsi V,Galtier F,Ivanciuc A,Meijer A,Mickiene A,Ikonen N,Gómez

更新日期：2020-05-01 00:00:00

abstract：:Highly pathogenic avian influenza A H5N1 viruses remain a significant health threat to humans given the continued rare occurrence of human cases with a high case fatality rate. This brief literature review summarizes available evidence of risk factors for H5N1 infection in humans and updates a recent systematic review...

journal_title：Influenza and other respiratory viruses

authors： Van Kerkhove MD

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The influenza virus is reportedly associated with 3-5 million cases of severe illness and 250 000-500 000 deaths annually worldwide. OBJECTIVES:We investigated the variation of influenza A virus in Korea and examined the association with death. METHODS:A total of 13 620 cases were enrolled in the Hospital-...

journal_title：Influenza and other respiratory viruses

authors： Lee HS,Noh JY,Song JY,Cheong HJ,Choi WS,Jeong HW,Wie SH,Kim WJ

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Since 2004, H5N1 outbreaks have been recurrent in domestic poultry and humans in Cambodia. To date, seven human cases (100% CFR) and 22 outbreaks in poultry have been confirmed. Household ownership of backyard poultry (FAO Sector 4 poultry production) in rural Cambodia is high. An understanding of the extent...

journal_title：Influenza and other respiratory viruses

authors： Van Kerkhove MD,Ly S,Holl D,Guitian J,Mangtani P,Ghani AC,Vong S

更新日期：2008-09-01 00:00:00