Abstract:
BACKGROUND:The relationship between obesity and susceptibility to influenza infection in humans is unclear. Morbidly obese people were at an increased risk of complications from 2009 pandemic H1N1 influenza [A(H1N1)pdm09]. OBJECTIVE:The goal of this study was to determine whether medically attended, laboratory-confirmed influenza is independently associated with obesity in adults with acute respiratory illness. PATIENTS/METHODS: Adults ≥20 years with a medical encounter for acute respiratory illness were recruited from a population cohort during the 2007-2008 (n = 903), 2008-2009 (n = 869), and 2009 pandemic (n = 851) season. Nasopharyngeal swabs were tested for influenza by real-time reverse-transcription polymerase chain reaction. Body mass index (BMI) was calculated using data from the electronic medical record. Logistic regression evaluated the association between influenza and obesity, adjusting for gender, vaccination, age, and high-risk medical condition. RESULTS:Influenza was detected in 50% of patients in 2007-2008, 15% in 2008-2009, and 14% during the 2009 pandemic. Predominant seasonal viruses in this population were A/H3N2 in 2007-2008, and A/H1N1 and B in 2008-2009. Mean (±SD) BMI was 30·58 (±7·31) in patients with influenza and 30·93 (±7·55) in test-negative controls during all seasons. Mean BMI of patients with influenza did not vary by season. After adjusting for confounders, neither obesity nor extreme obesity were associated with influenza by season or for all years combined (OR 0·95: 95% CI 0·75, 1·20 and 1·10: 0·80, 1·52, respectively, for obesity and extreme obesity, all years). CONCLUSIONS:Obesity was not associated with medically attended influenza among adults with acute respiratory illness in this population.
journal_name
Influenza Other Respir Virusesjournal_title
Influenza and other respiratory virusesauthors
Coleman LA,Waring SC,Irving SA,Vandermause M,Shay DK,Belongia EAdoi
10.1111/j.1750-2659.2012.00377.xsubject
Has Abstractpub_date
2013-03-01 00:00:00pages
160-7issue
2eissn
1750-2640issn
1750-2659journal_volume
7pub_type
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journal_title:Influenza and other respiratory viruses
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journal_title:Influenza and other respiratory viruses
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更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Influenza and other respiratory viruses
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更新日期:2010-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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更新日期:2013-11-01 00:00:00
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journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章
doi:10.1111/irv.12642
更新日期:2019-09-01 00:00:00
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journal_title:Influenza and other respiratory viruses
pub_type: 杂志文章,评审
doi:10.1111/j.1750-2659.2009.00090.x
更新日期:2009-07-01 00:00:00
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更新日期:2013-05-01 00:00:00
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更新日期:2018-05-01 00:00:00
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-07-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验,评审
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更新日期:2008-11-01 00:00:00
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pub_type: 历史文章,杂志文章
doi:10.1111/irv.12541
更新日期:2018-05-01 00:00:00