Low-dose oral interferon alpha as prophylaxis against viral respiratory illness: a double-blind, parallel controlled trial during an influenza pandemic year.

abstract：:Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA have been detected in some individuals following treatment. Here, we d...

journal_title：Influenza and other respiratory viruses

authors： Koszalka P,Farrukee R,Mifsud E,Vijaykrishna D,Hurt AC

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The 2009 pandemic H1N1 (A(H1N1)pdm09) influenza A virus (IAV) has replaced the previous seasonal H1N1 strain in humans and continues to circulate worldwide. The comparative performance of inactivated A(H1N1)pdm09 influenza vaccines remains of considerable interest. The objective of this study was to evaluate...

journal_title：Influenza and other respiratory viruses

authors： Vidaña B,Brookes SM,Everett HE,Garcon F,Nuñez A,Engelhardt O,Major D,Hoschler K,Brown IH,Zambon M

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:It has been suggested that live attenuated influenza vaccine (LAIV) may be less effective in older individuals because of prior wild-type influenza infections. LAIV is currently approved in the United States, South Korea and Hong Kong for individuals 2-49 years of age. OBJECTIVE:To examine data from previou...

journal_title：Influenza and other respiratory viruses

authors： Belshe RB,Toback SL,Yi T,Ambrose CS

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:To determined the pathogen-specific incidence of respiratory virus infection in Hutterite communities occurring over the 2008-2009 influenza season and assess temporal characteristics of respiratory illness related to infection. METHODS:3273 participants community members enrolled in a cluster randomized tr...

journal_title：Influenza and other respiratory viruses

authors： Kim TH,Russell ML,Fonseca K,Aoki F,Horsman G,Van Caeseele P,Chokani K,Voight M,Babiuk L,Moss L,Webby R,Earn DJ,Singh P,Howse C,Loeb M

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Nineteen mass vaccination clinics were established in Montreal, Canada, as part of the 2009 influenza A/H1N1p vaccination campaign. Although approximately 50% of the population was vaccinated, there was a considerable variation in clinic performance and community vaccine coverage. OBJECTIVE:To identify comm...

journal_title：Influenza and other respiratory viruses

authors： Charland KM,de Montigny L,Brownstein JS,Buckeridge DL

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The genetic and antigenic characteristics of influenza A viruses (IAV) within and between species change over time due to antigenic shift and drift. Although pigs are known to play a key role in the epidemiology of IAV between species, little is known about the molecular evolution of IAV hemagglutinin (HA) i...

journal_title：Influenza and other respiratory viruses

authors： Diaz A,Allerson M,Culhane M,Sreevatsan S,Torremorell M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Guillain-Barre syndrome (GBS) is a rare autoimmune disease characterized by acute, progressive peripheral neuropathy and is commonly associated with the presence of antiganglioside antibodies. Previously, influenza vaccination was linked with the increased incidence of GBS; however, whether antiganglioside a...

journal_title：Influenza and other respiratory viruses

authors： Wang DJ,Boltz DA,McElhaney J,McCullers JA,Webby RJ,Webster RG

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Molecular testing for viral pathogens has resulted in increasing detection of multiple viruses in respiratory secretions of ill children. The clinical impact of multiple virus infections on clinical presentation and outcome is unclear. OBJECTIVES:To compare clinical characteristics and viral load between ch...

journal_title：Influenza and other respiratory viruses

authors： Martin ET,Kuypers J,Wald A,Englund JA

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Acute respiratory infections (ARIs) are a major cause of morbidity and mortality worldwide. Influenza typically contributes substantially to the burden of ARI, but only limited data are available on influenza activity and seasonality in Jordan. METHODS:Syndromic case definitions were used to identify indivi...

journal_title：Influenza and other respiratory viruses

authors： Al-Abdallat M,Dawson P,Haddadin AJ,El-Shoubary W,Dueger E,Al-Sanouri T,Said MM,Talaat M

更新日期：2016-03-01 00:00:00

abstract：:We conducted a retrospective cohort study to evaluate the impact of obesity on influenza disease severity. Individuals with obesity were more likely to have lower pulmonary disease manifestations [OR=1·97 (95% CI 1·05, 3·69), P=0·03] and to be admitted to an inpatient ward [OR=2·93 (95% CI 1·50, 5·71), P=0·002] when c...

journal_title：Influenza and other respiratory viruses

authors： Martin ET,Archer C,McRoberts J,Kulik J,Thurston T,Lephart P,Kaye KS

更新日期：2013-11-01 00:00:00

abstract：:A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole-genome sequencing of 77 influenza A(H1N1)pdm0...

journal_title：Influenza and other respiratory viruses

authors： Komissarov A,Fadeev A,Sergeeva M,Petrov S,Sintsova K,Egorova A,Pisareva M,Buzitskaya Z,Musaeva T,Danilenko D,Konovalova N,Petrova P,Stolyarov K,Smorodintseva E,Burtseva E,Krasnoslobodtsev K,Kirillova E,Karpova L,Eropk

更新日期：2016-07-01 00:00:00

abstract：:An outbreak of highly pathogenic avian influenza A (H5N6) virus occurred between November 20, 2016, and March 1, 2017 in poultry farms, in the Gyeonggi Province, Republic of Korea. To identify the risk of transmission of H5N6 to depopulation workers, active and passive surveillance was conducted. Virological testing o...

journal_title：Influenza and other respiratory viruses

authors： Ryu S,Lim JS,Cowling BJ,Chun BC

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Recent outbreaks of highly pathogenic avian influenza and multiple occurrences of zoonotic infection and deaths in humans have sparked a dramatic increase in influenza research. In order to rapidly identify and help prevent future influenza outbreaks, numerous laboratories around the world are working to dev...

journal_title：Influenza and other respiratory viruses

authors： Bose ME,Littrell JC,Patzer AD,Kraft AJ,Metallo JA,Fan J,Henrickson KJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Human bocavirus (HBoV) is a novel parvovirus that is associated with respiratory and gastrointestinal tract disease. OBJECTIVES:To investigate the prevalence and genetic diversity of HBoV amongst hospitalized patients with acute lower respiratory infection (ALRI) in Cambodia. STUDY DESIGN:  Samples were co...

journal_title：Influenza and other respiratory viruses

authors： Arnott A,Vong S,Rith S,Naughtin M,Ly S,Guillard B,Deubel V,Buchy P

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Antibodies to neuraminidase (NA) contribute to protection during influenza virus infection, but NA inhibition (NI) titers are not routinely analyzed in vaccine trials. One reason is the cumbersome nature of the conventional thiobarbituric acid (TBA) NI assay, which uses chemical methods to quantify free sial...

journal_title：Influenza and other respiratory viruses

authors： Sandbulte MR,Gao J,Straight TM,Eichelberger MC

更新日期：2009-09-01 00:00:00

abstract：CONTEXT:Preventing nosocomial transmission of influenza is essential to reduce the morbidity and mortality associated with this infection. In October 2009, an outbreak of the 2009 influenza A (H1N1) virus occurred in a hematology ward of a children's hospital over a 21-day period and involved two patients and four heal...

journal_title：Influenza and other respiratory viruses

authors： Bearden A,Friedrich TC,Goldberg TL,Byrne B,Spiegel C,Schult P,Safdar N

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Reviews of the global response to the 2009 pandemic of influenza A/H1N1 affirmed the importance of assessment of preparedness and response capabilities. DESIGN:The U. S. Centers for Disease Control and Prevention (CDC) and partners developed the National Inventory of Core Capabilities for Pandemic Influenza...

journal_title：Influenza and other respiratory viruses

authors： MacDonald G,Moen AC,St Louis ME

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Minimal influenza surveillance has been carried out in sub-Saharan Africa to provide information on circulating influenza subtypes for the purpose of vaccine production and monitoring trends in virus spread and mutations. OBJECTIVE:The aim of this study was to investigate a surveillance program in Kenya to ...

journal_title：Influenza and other respiratory viruses

authors： Bulimo WD,Garner JL,Schnabel DC,Bedno SA,Njenga MK,Ochieng WO,Amukoye E,Magana JM,Simwa JM,Ofula VO,Lifumo SM,Wangui J,Breiman RF,Martin SK

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Estimating influenza incidence in outpatient settings is challenging. We used outpatient healthcare practice populations as a proxy to estimate community incidence of influenza-like illness (ILI) and laboratory-confirmed influenza-associated ILI. METHODS:From October 2009 to July 2010, 38 outpatient practic...

journal_title：Influenza and other respiratory viruses

authors： Fowlkes A,Dasgupta S,Chao E,Lemmings J,Goodin K,Harris M,Martin K,Feist M,Wu W,Boulton R,Temte J,Brammer L,Finelli L

更新日期：2013-09-01 00:00:00

abstract：:The emergence of a novel swine-origin pandemic influenza virus in 2009, together with the continuing circulation of highly pathogenic avian H5N1 viruses and the urgent global need to produce effective vaccines against such public health threats, has prompted a renewed interest in improving our understanding of the imm...

journal_title：Influenza and other respiratory viruses

authors： Haaheim LR,Katz JM

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Highly pathogenic H5N1 influenza viruses reemerged in humans in 2003 and have caused fatal human infections in Asia and Africa as well as ongoing outbreaks in poultry. These viruses have evolved substantially and are now so antigenically varied that a single vaccine antigen may not protect against all circul...

journal_title：Influenza and other respiratory viruses

authors： Ducatez MF,Webb A,Crumpton JC,Webby RJ

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:The goal of this investigation was to determine if acute influenza infection is associated with depletion of CoQ10 compared to healthy controls and to determine any associations between CoQ10 levels and illness severity and inflammatory biomarkers. PATIENTS AND METHODS:We analyzed serum CoQ10 concentrations...

journal_title：Influenza and other respiratory viruses

authors： Chase M,Cocchi MN,Liu X,Andersen LW,Holmberg MJ,Donnino MW

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Highly pathogenic avian influenza A/H5N1 virus remains a potential pandemic threat, and it is essential to continue vaccine development against this subtype. A local mucosal immune response in the upper respiratory tract may stop influenza transmission. It is therefore important to develop effective intranas...

journal_title：Influenza and other respiratory viruses

authors： Svindland SC,Pedersen GK,Pathirana RD,Bredholt G,Nøstbakken JK,Jul-Larsen Å,Guzmán CA,Montomoli E,Lapini G,Piccirella S,Jabbal-Gill I,Hinchcliffe M,Cox RJ

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In this study we investigated the levels of cytokines and chemokines produced locally and systemically after influenza vaccination of patients undergoing tonsillectomy. METHODS:Blood and saliva were collected prior to, and 1 or 2 weeks after vaccination at the time of the tonsillectomy. The cy...

journal_title：Influenza and other respiratory viruses

authors： Eriksson JC,Cox RJ,Szyszko E,Davidsson A,Brokstad KA

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is a leading etiological agent of acute respiratory tract infections and hospitalizations in children. However, little information is available regarding RSV infections in Latin American countries, particularly among adult patients. OBJECTIVE:To describe the epidemiology of...

journal_title：Influenza and other respiratory viruses

authors： Gamiño-Arroyo AE,Moreno-Espinosa S,Llamosas-Gallardo B,Ortiz-Hernández AA,Guerrero ML,Galindo-Fraga A,Galán-Herrera JF,Prado-Galbarro FJ,Beigel JH,Ruiz-Palacios GM,Noyola DE,Mexico Emerging Infectious Diseases Clinical Research Net

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:To preliminary preview the molecular character and its possible clinical correlation of RSV subgroups in Thailand. DESIGN:Cross-sectional analytic design. SETTING:Admitted acute lower respiratory tract infection patients of King Chulalongkorn Memorial Hospital, Bangkok, during Jun-Dec, 2007 were recruited....

journal_title：Influenza and other respiratory viruses

authors： Boonyasuppayakorn S,Kowitdamrong E,Bhattarakosol P

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Modern molecular techniques reveal new information on the role of respiratory viruses in community-acquired pneumonia. In this study, we tried to determine the prevalence of respiratory viruses and bacteria in patients with community-acquired pneumonia who were admitted to the hospital. METHODS:Between Apri...

journal_title：Influenza and other respiratory viruses

authors： Huijskens EG,van Erkel AJ,Palmen FM,Buiting AG,Kluytmans JA,Rossen JW

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Acute respiratory infections are a leading cause of morbidity and mortality worldwide. Starting in 2009, pandemic influenza A(H1N1) 2009 virus has become one of the leading respiratory pathogens worldwide. However, the overall impact of this virus as a cause of mortality has not been clearly defined. OBJECT...

journal_title：Influenza and other respiratory viruses

authors： Comas-García A,García-Sepúlveda CA,Méndez-de Lira JJ,Aranda-Romo S,Hernández-Salinas AE,Noyola DE

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The annual differences in the seasonal influenza vaccine and the circulating strains make it necessary to assess influenza vaccine effectiveness (VE) yearly. We assessed the effectiveness of the trivalent inactivated influenza vaccine for the 2010-2011 and 2011-2012 influenza seasons among children in Guangz...

journal_title：Influenza and other respiratory viruses

authors： Fu C,He Q,Li Z,Xu J,Li Y,Lu J,Li K,Yang Q,Dong Z,Liu X,Wen S,Hu W,Zhang D,Lv J,Zhu W,Wang M

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Despite the use of vaccines, low-pathogenic (LP) H5N2 influenza viruses have continued to circulate and evolve in chickens in Mexico since 1993, giving rise to multiple genetic variants. Antigenic drift is partially responsible for the failure to control H5N2 influenza by vaccination; the contribution of mat...

journal_title：Influenza and other respiratory viruses

authors： Forrest HL,Garcia A,Danner A,Seiler JP,Friedman K,Webster RG,Jones JC

更新日期：2013-11-01 00:00:00