Abstract：
PURPOSE:Animal and laboratory studies suggest that long-chain omega-3 (n-3) fatty acids, a type of polyunsaturated fat found in fatty fish, may protect against carcinogenesis, but human studies on dietary intake of polyunsaturated fats and fish with endometrial cancer risk show mixed results. METHODS:We evaluated the associations between endometrial cancer risk and intake of fatty acids and fish in a population-based sample of 556 incident cancer cases and 533 age-matched controls using multivariate unconditional logistic regression methods. RESULTS:Although total n-3 fatty acid intake was not associated with endometrial cancer risk, higher intakes of eicosapentaenoic (EPA 20:5) and docosahexaenoic (DHA 22:6) fatty acids were significantly associated with lower risks (OR = 0.57, 95 % CI: 0.39-0.84; OR = 0.64, 95 % CI: 0.44-0.94; respectively) comparing extreme quartiles. The ratio of n-3:n-6 fatty acids was inversely associated with risk only on a continuous scale (OR = 0.84, 95 % CI: 0.71-0.99), while total fish intake was not associated with risk. Fish oil supplement use was significantly associated with reduced risk of endometrial cancer: OR = 0.63 (95 % CI: 0.45-0.88). CONCLUSIONS:Our results suggest that dietary intake of the long-chain polyunsaturated fatty acids EPA and DHA in foods and supplements may have protective associations against the development of endometrial cancer.
journal_name
Eur J Nutrjournal_title
European journal of nutritionauthors
Arem H,Neuhouser ML,Irwin ML,Cartmel B,Lu L,Risch H,Mayne ST,Yu Hdoi
10.1007/s00394-012-0436-zsubject
Has Abstractpub_date
2013-04-01 00:00:00pages
1251-60issue
3eissn
1436-6207issn
1436-6215journal_volume
52pub_type
杂志文章abstract：BACKGROUND:Present animal models used to emulate type 2 diabetes may not accurately reflect the metabolic changes that occur in humans. AIM OF THE STUDY:The purpose of this research was to evaluate diets reported to induce insulin resistance and impaired glucose metabolism in rats as a potentially useful model for stu...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s003940070016
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Bioavailability studies with lycopene have focused on natural sources. A synthetic source has recently become available. AIM OF THE STUDY:To determine the relative bioavailabilities of synthetic and tomato-based lycopene in free living volunteers in a single-blind, randomized, placebo-controlled, parallel t...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-003-0421-7
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:Our recent study has reported that whole mung bean showed better beneficial effects on high-fat diet (HFD)-induced obesity and gut microbiota disorders when compared with the decorticated mung bean at the same intervention dose level, suggesting that the mung bean seed coat (MBC) may play a crucial role in its ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02395-x
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Adipose tissue-associated chronic inflammation is involved in the pathogenesis of obesity-related diseases. Dietary fatty acids are known to influence inflammatory processes. The aim of this study was to investigate, whether diets with regular fat contents but variable fat qualities affect adipose tissue-associ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0518-6
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Extensive exercise may promote the formation of reactive oxygen species and subsequently contribute to tissue damage. A compound which can protect cells and tissues is vitamin E. The vitamin E radical, formed during the radical scavenging process, can be reduced by vitamin C resulting in a higher level of th...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00394-003-0414-6
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:At the present time the recommended daily intake or allowance (RDA) and the safe upper level (UL) of intake of micronutrients are given as single values. The recommended daily intake is considered to cover the requirements of 97.5% of the population while the safe upper level is a value for the whole populat...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-007-0691-6
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Dietary polyphenols have been reported to have a variety of biological actions, including anticarcinogenic and antioxidant activities. AIM OF THE STUDY:In the present study we investigated the protective effect of dietary polyphenols against N-nitrosodimethylamine (NDMA), N-nitrosopyrrolidine (NPYR) and ben...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-008-0751-6
更新日期：2008-12-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the association between adipose tissue content of the plant-derived n-3 fatty acid, alpha-linolenic acid, and the rate of incident peripheral artery disease (PAD). METHODS:We conducted a case-cohort study nested within the Danish Diet, Cancer and Health cohort (n = 57,0...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02159-2
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Several studies have demonstrated the properties of hydroxytyrosol, a phenolic compound present in olive oils and olives with a well-characterized impact on human health. Nevertheless, some knowledge gaps remain on its bioavailability and metabolism; overall concerning to the real rate per cent of absorption an...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02295-0
更新日期：2020-06-10 00:00:00
abstract：BACKGROUND:Lutein is a carotenoid that may play a role in eye health. Human milk typically contains higher concentrations of lutein than infant formula. Preliminary data suggest there are differences in serum lutein concentrations between breastfed and formula-fed infants. AIM OF THE STUDY:To measure the serum lutein ...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-009-0047-5
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:Alcoholic liver disease or non-alcoholic fatty liver disease/non-alcoholic steatohepatitis are well-known risk factors for liver fibrosis or cirrhosis and hepatocellular carcinoma; it is a major global health concern, but there are few effective and safe management options. Therefore, we aimed to investigate th...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-016-1318-6
更新日期：2017-08-01 00:00:00
abstract：AIM OF THIS STUDY:was to assess the validity of a 3-day estimated dietary record, especially developed for the longitudinal study on nutrition and health status in an aging population (aged > or = 60 years) in Giessen, Germany. METHODS:The dietary record comprises 146 food items. Portion sizes of the foods consumed we...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s003940050066
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:Results from epidemiologic studies on coffee consumption and the risk of cutaneous melanoma are inconsistent. We conducted a meta-analysis to assess the associations between the consumption of total coffee, caffeinated coffee and decaffeinated coffee and the risk of cutaneous melanoma, respectively. METHODS:A ...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00394-015-1139-z
更新日期：2016-06-01 00:00:00
abstract：PURPOSE:Essential fatty acids are critical for brain growth and neurodevelopment in infancy. Maternal diet and supplement use have a significant impact on the fat composition of human milk. The objective of this study is to assess supplement utilization patterns and fatty acid and brain-derived neurotrophic factor (BDN...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1793-z
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:Poor sperm quality is a major contributor to infertility in heterosexual couples, but at present there are few empirical therapies. Several studies have examined the role of dietary factors and data from randomized controlled trials suggest that oral antioxidant therapy can improve some sperm parameters. Health...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-019-02091-5
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:In addition to regulating calcium homoeostasis and bone health, vitamin D influences vascular and metabolic processes including endothelial function (EF) and insulin signalling. This systematic review and meta-analysis of randomised clinical trials (RCTs) were conducted to investigate the effect of vitamin D...
journal_title：European journal of nutrition
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00394-016-1159-3
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:Fruit and vegetable intake has been inversely associated with the risk of hypertension; however, there is inconsistent evidence on the long-term association. Given this gap in the literature, it is necessary to identify evidence from large prospective studies, especially in China, where insufficient evidence ex...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1687-0
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Constitutive activation of the Wnt signaling pathway and its downstream effectors plays a key role in neoplastic transformation. The objective of this study was to investigate the effect of ellagic acid, a plant-derived polyphenol on Wnt/β-catenin signaling and its downstream circuits- NF-κB and mitochondrial a...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-011-0288-y
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:Green tea is thought to possess many beneficial effects on human health. However, the extent of green tea polyphenol biotransformation may affect its proposed therapeutic effects. Catechol-O-methyltransferase (COMT), the enzyme responsible for polyphenolic methylation, has a common polymorphism in the genetic c...
journal_title：European journal of nutrition
pub_type： 临床试验,杂志文章
doi：10.1007/s00394-011-0189-0
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:To get insight in the impact of fish and fat intake in the prevention of accelerated cognitive decline with ageing, we tested associations between fish and different fat intakes and 5-year change in cognitive functions. METHODS:In 2612 men and women of the Doetinchem Cohort Study, aged 43-70 years at baseline,...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-017-1453-8
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:To analyze the presence of total IgA and anti-gliadin antibodies (AGA) in BM from CD mothers who follow a gluten-free diet (GFD) and from mothers on a normal gluten-containing diet (ND). METHODS:218 samples of mature milk were obtained at different months of lactation (1-6) from 83 mothers (2 or more samples p...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-017-1476-1
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:The enzymes encoded by fatty acid desaturases (FADS) genes determine the desaturation of long-chain polyunsaturated fatty acids (LCPUFA). We investigated if haplotype and single nucleotide polymorphisms (SNPs) in FADS gene cluster can influence LCPUFA status in infants who received either fish oil or placebo su...
journal_title：European journal of nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00394-017-1529-5
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Compared to a healthy population, the gut microbiota in type 2 diabetes presents with several unfavourable features that may impair glucose regulation. The aim of this study was to evaluate the prebiotic effect of inulin-type fructans on the faecal microbiota and short-chain fatty acids (SCFA) in patients with ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-020-02282-5
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:Little is known about the effects of leptin and leptin receptor polymorphisms on lipid changes during pregnancy. The aims of this study were to evaluate the associations between the single nucleotide polymorphisms (SNPs) of leptin and leptin receptor genes and the lipid concentrations during pregnancy; and to t...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-02049-7
更新日期：2020-08-01 00:00:00
abstract：PURPOSE:Rebalancing the contribution of animal- and plant-based foods is needed to achieve sustainable diet. However, little is known concerning individual characteristics that may influence intake of plant-based foods and their changes over time. We aimed to assess changes in the contribution of plant-based foods to d...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-018-1752-8
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:L-Theanine is the major free amino acid present in tea (Camellia sinensis L.). The effects of several tea constituents on male reproduction have been investigated, but L-theanine has been overlooked. Sertoli cells (SCs) are essential for the physical and nutritional support of germ cells. In this study, we aime...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-019-01999-2
更新日期：2019-10-01 00:00:00
abstract：INTRODUCTION:Organic acids from plant food have been shown to play an important role in the prevention of chronic diseases (osteoporosis, obesity), inherent to western diets, but little is known about their bioavailability in the small intestine, information that needs to be determined in order to quantify likely effec...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-010-0112-0
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:Previous evidence for the associations of eating frequency and food consumption with clustering of metabolic risk factors among children is limited. We therefore investigated association of the daily number of main meals and snacks and food consumption with a metabolic risk score and individual metabolic risk f...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0646-z
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Iodine fortification programs have been applied in many iodine deficient regions. Iodine excess is also unfavourable, and it is recommended to monitor iodine status by measuring urinary iodine concentration (UIC). The number of samples needed in such monitoring depends on the variation in UIC. However, it is...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-013-0551-5
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Grapes and wine contain high concentrations of polyphenolic compounds. Although their cancer protective effect has been well documented, their activity as anticarcinogens should be cautiously considered since the molecular bases of action and their applicability to human cancer prevention are still unclear. ...
journal_title：European journal of nutrition
pub_type： 杂志文章
doi：10.1007/s00394-003-0398-2
更新日期：2003-01-01 00:00:00
