Abstract：
:Stereological studies showed that treatment of normal adult human adrenocortical cells in primary culture with ACTH or cyclic-AMP for 2 days results in similar increases in the volume of cells, of the mitochondrial and "membrane space" compartments and of the surface area of the smooth endoplasmic reticulum and mitochondrial cristae, and decrease in the lipid content of the cells. These changes were more marked after 8 days of treatment. Treatment for 2 days with cyclic-GMP had no striking effects on cell ultrastructure, whereas an 8-day treatment led to ultrastructural changes similar to those obtained after 2 days of ACTH- or cyclic-AMP-treatment. A discrete population of untreated cortical cells maintained a slow proliferation that was not effected by exposure to cyclic-GMP, but was significantly increased in cultures treated with ACTH or cyclic-AMP. Radioimmunological studies showed that untreated cortical cells kept secreting progesterone and cortisol and that ACTH, but neither cyclic nucleotide, increased the secretion rate per cell of both hormones. These results assign a major role to cyclic-AMP and a minor one to cyclic-GMP in the mediation of the differentiation-promoting and trophic effects, but not in the steroidogenic effects of ACTH on the human adrenal cortex.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Armato U,Nussdorfer GG,Neri G,Draghi E,Andreis PG,Mazzocchi G,Mantero Fdoi
10.1007/BF00218169subject
Has Abstractpub_date
1978-07-05 00:00:00pages
187-205issue
2eissn
0302-766Xissn
1432-0878journal_volume
190pub_type
杂志文章abstract：:The isolated perfused heart model was used to examine the structure of rat cardiac capillaries and their permeability to macromolecules of various sizes. Haemoglobin (diameter 6.4 nm) and catalase (10.4 nm) did not cross the endothelium but remained on the luminal side. Cytochrome C (3 nm) and horseradish peroxidase (...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00213826
更新日期：1988-04-01 00:00:00
abstract：:The gross structure as well as the neuronal and non-neuronal components of the lamina ganglionaris of the locust Schistocerca gregaria are described on the basis of light- and electron-microscopical preparations of Golgi (selective silver) and ordinary histological preparations. The array of optic cartridges within th...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00233626
更新日期：1981-01-01 00:00:00
abstract：:Neuropeptide F in invertebrates is a homolog of neuropeptide Y in mammals and it is a member of FMRFamide-related peptides. In arthropods, such as insects, there are two types of neuropeptide F comprising long neuropeptide F (NPF) and short neuropeptide F (sNPF). Both NPFs are known to play a crucial role in the regul...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-019-02999-8
更新日期：2019-06-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1477-6
更新日期：2012-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF02913723
更新日期：1993-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218796
更新日期：1989-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410000265
更新日期：2000-12-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0561-9
更新日期：2008-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050551
更新日期：1996-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-011-1303-6
更新日期：2012-02-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-020-03211-y
更新日期：2020-05-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237886
更新日期：1980-01-01 00:00:00
abstract：:In vitro incubation of autonomic nerves with vinblastine sulphate (1 times 10(-4) M) caused a disappearance of microtubules within 15 min; during the following 15 min paracrystalline arrays appeared within the axons. An increase in the abundance of microfilaments was also observed, but these did not appear to arise fr...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00220136
更新日期：1976-02-25 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00319144
更新日期：1995-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-015-2315-4
更新日期：2016-01-01 00:00:00
abstract：:The distribution of the glycoprotein, mucin 1 (MUC1), was determined in lactating guinea-pig mammary tissue at the resolution of the electron microscope. MUC1 was detected on the apical plasma membrane of secretory epithelial cells, the surface of secreted milk-fat globules, the limiting membranes of secretory vesicle...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410100351
更新日期：2001-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0522-3
更新日期：2008-02-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-011-1160-3
更新日期：2011-06-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215708
更新日期：1982-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00209040
更新日期：1978-10-17 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00233732
更新日期：1980-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050820
更新日期：1997-05-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2956-1
更新日期：2019-04-01 00:00:00
abstract：:Rat endometrial explants were cultured in a three-dimensional collagen/endothelial cell matrix to measure angiogenic activity, as represented by migration of vascular endothelial cells towards the explants. Minimal endothelial cell migratory activity was observed with endometrial explants taken during the four-day oes...
journal_title：Cell and tissue research
pub_type： 历史文章,杂志文章
doi：10.1007/BF00300706
更新日期：1995-01-01 00:00:00
abstract：:Vitrification of biological specimens in liquid nitrogen can be achieved under high pressure (2,100 bars). This procedure obviates the use of aldehyde fixation and cryoprotection (glycerol). The present work demonstrates its applicability to the freeze-etching of mammalian brain tissue. Freeze-fracture repicas from ra...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237626
更新日期：1980-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-020-03241-6
更新日期：2020-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218204
更新日期：1987-05-01 00:00:00
abstract：:The ultrastructure of the isolated glycerinated penis retractor muscle (PRM) of Helix pomatia was investigated. The diameter distributions of thick myofilaments from birbre cross sections in the relaxed, phasic contracted, tonic contracted, and in the catch state.s show that a characteristic filament spectrum is forme...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221808
更新日期：1975-01-01 00:00:00
