Abstract:
:It is clear that the well-described phenomenon of epithelial-mesenchymal transition (EMT) plays a pivotal role in embryonic development, wound healing, tissue regeneration, organ fibrosis and cancer progression. EMTs have been classified into three subtypes based on the functional consequences and biomarker context in which they are encountered. This review will highlight findings on type II EMT as a direct contributor to the kidney myofibroblast population in the development of renal fibrosis, specifically in diabetic nephropathy, the signalling molecules and the pathways involved in type II EMT and changes in the expression of specific miRNA with the EMT process. These findings have provided new insights into the activation and development of EMT during disease processes and may lead to possible therapeutic interventions to suppress EMTs and potentially reverse organ fibrosis.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Carew RM,Wang B,Kantharidis Pdoi
10.1007/s00441-011-1227-1subject
Has Abstractpub_date
2012-01-01 00:00:00pages
103-16issue
1eissn
0302-766Xissn
1432-0878journal_volume
347pub_type
杂志文章,评审abstract::The effects of radiotherapy on neuropeptide expression in the rat larynx were studied. Irradiation was given for five days, 6 or 8 Gray daily. Ten days after the end of irradiation, the larynx, the laryngeal nerves and different ganglia related to the larynx were dissected out from irradiated and control animals and p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00300691
更新日期:1995-01-01 00:00:00
abstract::CD4+CD25+(high) regulatory T cells (Tregs) play a pivotal role in the control of the immune response. A growing body of evidence suggests the reduced function of these cells in autoimmune diseases, including type 1 diabetes (T1D). Restoration of their function can potentially delay further disease development. In the ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0900-0
更新日期:2010-03-01 00:00:00
abstract::This report demonstrates that the administration of testosterone (T) or 11-ketotestosterone (11-KT) to sexually immature (8 wks old) male platyfish (Xiphophorus maculatus) of early- and late-maturing genotypes affects the synthesis and/or release of luteinizing hormone-releasing hormone (LHRH), as assessed by immunocy...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218552
更新日期:1986-01-01 00:00:00
abstract::Light microscopy of native preparations, histology, and electron microscopy have revealed that Phlebotomus duboscqi belongs to a class of sand fly species with prompt development of the peritrophic matrix (PM). Secretion of electron-lucent fibrils, presumably chitin, starts immediately after the ingestion of a blood m...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0802-1
更新日期:2009-08-01 00:00:00
abstract::The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is thought to regulate crucial cellular functions such as mitosis, apoptosis, migration, differentiation and communication between organelles as a scaffold protein. These diverse functions are modulated by the tyrosine/serine phosphorylation status of P...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-016-2508-5
更新日期:2017-06-01 00:00:00
abstract::Immunoreactivity for calcitonin gene-related peptide is demonstrated for the first time in neuroepithelial bodies in the lung of newborn cats after Bouin fixation and embedding in paraffin. The intense staining clearly identifies these bodies at the level of bronchioli and alveoli. Occasionally, single neuroepithelial...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215517
更新日期:1987-08-01 00:00:00
abstract::The present study attempts to elucidate the role of TRPV1 cation channel receptor on primary repair in an incision-wounded mouse cornea in vivo. Previous study revealed that blocking TRPV1 suppressed myofibroblast formation and expression of transforming growth factor β1 (TGFβ1) in cultured keratocytes or ocular fibro...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2878-y
更新日期:2018-11-01 00:00:00
abstract::In this study, we focus on the specific contribution of β integrin-like protein to adhesion-mediated events in molluscan larval cells in culture that could not have been investigated within the whole animal. An analysis of disturbances to cell-substratum adhesion, caused by the integrin receptor inhibiting Arg-Gly-Asp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2122-y
更新日期:2015-08-01 00:00:00
abstract::The localization of autologous antiperoxidase immunoglobulin G (IgG) was studied in the choroid plexus of Lewis rats immunized against horseradish peroxidase (HRP). This experiment was performed to study the permeability of the choroid plexus to intravascular IgG. It was shown that autologous IgG was present in the ex...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215159
更新日期:1984-01-01 00:00:00
abstract::Chronological changes in renal glomerular morphology and plasma renin activity were investigated during active and hibernating periods in the golden-mantled ground squirrel Spermophilus lateralis. The objective of this study was to determine whether the glomerular endothelium, visceral epithelium (podocytes), basement...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00327750
更新日期:1990-10-01 00:00:00
abstract::When stimulated by the feeding of ethylenethiourea for a period of 6 months, dog thyroid glands increased to approximately 30 times their normal size. Not only follicular cells but also C cells had hyperplastic and hypertrophic features, compared with normal controls there was in the C cells a marked decrease in secre...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214684
更新日期:1982-01-01 00:00:00
abstract::The notion that teeth contain stem cells is based on the well-known repairing ability of dentin after injury. Dental stem cells have been isolated according to their anatomical locations, colony-forming ability, expression of stem cell markers, and regeneration of pulp/dentin structures in vivo. These dental-derived s...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-007-0467-6
更新日期:2008-01-01 00:00:00
abstract::The inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular Ca2+ release channel responsible for mobilizing stored Ca2+. Three different receptor types have been molecularly cloned, and their genes have been classified into a family. The gene for the type 1 receptor (IP3R1) is predominantly expressed in cereb...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00307790
更新日期:1995-05-01 00:00:00
abstract::Research in mammals has demonstrated a variety of regulatory effects of vasopressin and oxytocin on endocrine functions of the anterior pituitary gland. Less evidence is available regarding the hypophysiotropic action of arginine vasotocin (AVT) comprising vasopressic and oxytocic activities in birds. Some hypophysiot...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0636-2
更新日期:2008-08-01 00:00:00
abstract::A striking feature of vestibular hair cells is the polarized arrangement of their stereocilia as the basis for their directional sensitivity. In mammals, each of the vestibular end organs is characterized by a distinct distribution of these polarized cells. We utilized the technique of post-fixation transganglionic ne...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-010-0944-1
更新日期:2010-05-01 00:00:00
abstract::The pineal gland structure and ultrastructure in the Northern (Blarina brevicauda) and Southern short-tailed shrew (Blarina carolinensis) are described by light and electron microscopy. Results observed were similar to other mammals of Insectivora described previously, specifically, the hedgehog (Erinaceus europaeus) ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2897-8
更新日期:2018-12-01 00:00:00
abstract::The grey level index (= GLI) and the fresh voluem were determined with the image analyser Micro-Videomat for the nucl. n. facialis after axotomy of the left n. facialis. The experiments were performed on 10 rats in different stages of ontogenesis. The GLI is a quantitative parameter which could be quickly obtained and...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218176
更新日期:1978-07-05 00:00:00
abstract::Many efforts have been made to improve the diagnostic tools used to identify and to estimate the progress of ganglion cell and nerve fibre degeneration in glaucoma. Imaging by optical coherence tomography and measurements of the dimensions of the optic nerve head and the nerve fibre layer in central retinal areas is c...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1602-1
更新日期:2013-08-01 00:00:00
abstract::Expression of the non-muscle myosin heavy chain-B (NM-MHC-B, also denoted as the embryonic smooth muscle myosin heavy chain, SMemb) was examined in rat urinary bladder during growth in response to a partial urinary outflow obstruction. Following obstruction, the weight of the urinary bladder increased more than five-f...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410000262
更新日期:2001-05-01 00:00:00
abstract::We compared the bone regeneration potentials of autologous cultured osteoblasts and of bone-marrow-derived autologous MSCs in combination with allogeneic cancellous bone granules in a rabbit radial defect model. Radial shaft defects over 15 mm were made in 26 New Zealand white rabbits. The animals underwent insertion ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1272-9
更新日期:2012-02-01 00:00:00
abstract::Subsurface cisterns (SSC's) and less frequent lamellar bodies (LB's) were identified in the granule cells of the guinea-pig fascia dentata. Both structures, composed of flattened or collapsed agranular cisterns, are continuous with the regular rough endoplasmic reticulum and occasionally connected with each other form...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF01258502
更新日期:1982-01-01 00:00:00
abstract::The distributions within the coeliac ganglion of different chemically coded subgroups of noradrenaline neurons, and the relationships between these neurons and nerve fibres projecting to the ganglion from the intestine, have been assessed quantitatively by use of an immunohistochemical double-staining method. Noradren...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218395
更新日期:1986-01-01 00:00:00
abstract::The distribution of neuronal elements immunoreactive for gamma-aminobutyric acid (GABA) and glycine in the cochlear nucleus of the mustached bat Pteronotus parnellii has been studied by means of the postembedding technique on serial semithin sections. Our goal has been to identify similarities and differences in the o...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050773
更新日期:1997-02-01 00:00:00
abstract::Putative neural stem cells have been identified within the enteric nervous system (ENS) of adult rodents and cultured from human myenteric plexus. We conducted studies to identify neural stem cells or progenitor cells within the submucosa of adult human ENS. Jejunum tissue was removed from adult human subjects undergo...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1130-9
更新日期:2011-05-01 00:00:00
abstract::Vesicular transport involves SNARE (soluble- N-ethylmaleimide-sensitive-factor-attachment-protein-receptor) proteins on transport vesicles and on target membranes. Syntaxin 13 is a SNARE enriched in brain, associated with recycling endosomes; its overexpression in PC12 cells promotes neurite outgrowth. This suggests a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0600-5
更新日期:2002-08-01 00:00:00
abstract::The bursa of Fabricius of the chicken is known to be both a primary lymphoid organ and a secondary lymphoid tissue. Bursal follicles are equipped with antigen-trapping follicle-associated epithelium. However, bioactive antigens such as protein and bacteria have not been detected in the bursal parenchyma. By immunopero...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1701-z
更新日期:2013-12-01 00:00:00
abstract::Mole rat bone marrow cells and peritoneal eosinophils are used to study granule morphological maturation by quantitative microscopy. The bulk eosinophil granule content is pre-stored in unique granular structures known as crystalloid or secondary granules. Mole rat eosinophil granules exhibit the basic structure of an...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2189-5
更新日期:2015-10-01 00:00:00
abstract::In the intestine of the filtering zooids of B. schlosseri three segments can be distinguished. In the intermediate segment the epithelium, which is encrusted by the ampullae of the pyloric gland, shows marked aspects of alteration. In the proximal and distal segments, ciliated mucous, vacuolated and endocrine-like cel...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219771
更新日期:1977-08-26 00:00:00
abstract::The protonephridial flame cell of the freshwater planarian Bdellocephala brunnea was studied by electron microscopy. This basketlike cell with luminal cilia and fenestrae is known as a cyrtocyte. Careful examination revealed the actual continuity of the fenestrae over the surface of the cell and the microvillous natur...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00237973
更新日期:1980-01-01 00:00:00
abstract::Using a somatostatin-gold conjugate of known biological activity, high affinity binding sites for this neuropeptide were visualized at cellular resolution on cultured diencephalic astrocytes and on frozen sections of the rat diencephalon. Binding could be completely suppressed in competition experiments with surplus u...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318767
更新日期:1991-02-01 00:00:00