Localization of diazepam-binding inhibitor-related peptides and peripheral type benzodiazepine receptors in the frog adrenal gland.


:The adrenal gland of mammals contains high concentrations of peripheral-type benzodiazepine receptors (PBR) and diazepam-binding inhibitor (DBI), a polypeptide which acts as an endogenous ligand for PBR. The aim of the present study was to investigate the localization of DBI and PBR in the adrenal gland of the frog Rana ridibunda. Reverse transcription followed by polymerase chain reaction with specific primers for the frog DBI cDNA showed the presence of DBI mRNA in frog adrenal gland extracts. The cellular distribution of DBI and PBR was investigated using an antiserum against the octadecaneuropeptide DBI [33-50] (ODN) and antibodies against the 18-kDa isoquinoline binding protein subunit of PBR (IBP), respectively. ODN-like immunoreactivity was found in chromaffin cells and in Stilling s cells, but not in adrenocortical cells. IBP-like immunoreactivity was observed in chromaffin cells, in Stilling s cells and in a small proportion (11%) of steroid-secreting cells. The ODN- and IBP-immunoreactive materials were homogeneously distributed in the cytoplasm of chromaffin cells and concentrated at the periphery of large cytoplasmic vesicles in Stilling s cells. The proportion of ODN-positive Stilling s cells showed marked circannual variations with a maximum in July. Similarly, the proportion of IBP-positive Stilling s cells was 17 times higher in July than in December. These results indicate that, in the frog adrenal gland, DBI-related peptides and PBR are simultaneously expressed in chromaffin cells and Stilling s cells, suggesting that endogenous ligands for PBR may play a physiological role in the control of adrenal cell activity.


Cell Tissue Res


Cell and tissue research


Lesouhaitier O,Feuilloley M,Lihrmann I,Ugo I,Fasolo A,Tonon MC,Vaudry H




Has Abstract


1996-03-01 00:00:00












  • Neuronal background of activation of estivated snails, with special attention to the monoaminergic system: a biochemical, physiological, and neuroanatomical study.

    abstract::Osmotic stimulation activates both estivated and inactivated specimens of Helix pomatia and increases their central arousal. High-pressure liquid chromatography has shown that, during activation, the level of both serotonin and dopamine decreases in the central nervous system (CNS) but increases in the foot and heart,...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Hernádi L,Vehovszky A,Gyori J,Hiripi L

    更新日期:2008-02-01 00:00:00

  • Neurofilament dynamics and involvement in neurological disorders.

    abstract::Neurons are extremely polarised cells in which the cytoskeleton, composed of microtubules, microfilaments and neurofilaments, plays a crucial role in maintaining structure and function. Neurofilaments, the 10-nm intermediate filaments of neurons, provide structure and mechanoresistance but also provide a scaffolding f...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Gentil BJ,Tibshirani M,Durham HD

    更新日期:2015-06-01 00:00:00

  • Embryonic and postnatal development of masticatory and tongue muscles.

    abstract::This review summarizes findings concerning the unique developmental characteristics of mouse head muscles (mainly the masticatory and tongue muscles) and compares their characteristics with those of other muscles. The developmental origin of the masticatory muscles is the somitomeres, whereas the tongue and other musc...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Yamane A

    更新日期:2005-11-01 00:00:00

  • Recognition of sodium- and potassium-dependent adenosine triphosphatase in organs of the mouse by means of a monoclonal antibody.

    abstract::The antigen detected by the rat anti-mouse monoclonal antibody (m Ab), anti-BSP-3, has been initially described as a brain cell-surface protein. Evidence is presented that this m Ab recognizes mouse (Na+ + K+)-ATPase (ATP phosphohydrolase, E.C. The antigen, purified from mouse brain by means of affinity chrom...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Gorvel JP,Liabeuf A,Massey D,Liot D,Goridis C,Maroux S

    更新日期:1983-01-01 00:00:00

  • CRF-containing neurons of the rat hypothalamus.

    abstract::The immunoreactive CRF-neurons of the rat hypothalamus have been examined immunohistochemically employing anti-rat CRF serum. These neurons are confined to the paraventricular nucleus, dorsomedial-lateral hypothalamic area, and suprachiasmatic nucleus, and are, respectively, also immunoreactive to anti-Met-enk, -alpha...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Daikoku S,Okamura Y,Kawano H,Tsuruo Y,Maegawa M,Shibasaki T

    更新日期:1985-01-01 00:00:00

  • Localization of hydroxyindole O-methyltransferase-synthesizing cells in bovine epithalamus: immunocytochemistry and in-situ hybridization.

    abstract::Hydroxyindole O-methyltransferase (HIOMT)-immunoreactive cells and melatonin synthesis were demonstrated in bovine epithalamus (including the pineal gland) with monoclonal antibodies and cRNA probes to HIOMT. The HIOMT-immunoreactive product was present in the cytoplasm of pinealocytes. All identifiable pinealocytes w...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Sato T,Deguchi T,Ichikawa T,Fujieda H,Wake K

    更新日期:1991-03-01 00:00:00

  • The influence of phenylthiourea (PTU) on the pigment epithelium and the photoreceptor cells in the developing retina of Haplochromis burtoni (Cichlidae, Teleostei).

    abstract::The effect of phenylthiourea (PTU) on the pigment epithelium and the photoreceptor cells in the developing retina of Haplochromis burtoni was studied by electron microscopy. In the retinal pigment epithelium of 6-day old embryos, both types of melanin granule (spindle-shaped and rod-shaped) are already found. PTU inhi...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Pietzsch-Rohrschneider I

    更新日期:1977-03-09 00:00:00

  • Immunohistochemical study of 5-HT-containing neurons in the teleost intestine: relationship to the presence of enterochromaffin cells.

    abstract::The formaldehyde-induced fluorescence technique had shown 5-hydroxytryptamine-containing enteric neurons in the intestine of the teleost Platycephalus bassensis, but did not reveal such neurons in the intestine of Tetractenos glaber or Anguilla australis. Re-examination of these animals with 5-hydroxytryptamine immuno...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Anderson C,Campbell G

    更新日期:1988-01-01 00:00:00

  • Gene expression of beta-catenin is up-regulated in inner dental epithelium and enamel knots during molar tooth morphogenesis in the mouse.

    abstract::Beta-catenin is a multi-functional molecule that is involved in both cell-cell adhesion and signaling. We analyzed changes in beta-catenin gene expression during mouse molar tooth development by in situ hybridization. Prominent up-regulation of the expression of this gene was evident exclusively in the enamel knot at ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Obara N,Suzuki Y,Takeda M

    更新日期:2006-07-01 00:00:00

  • Oxytetracycline reduces inflammation and treponeme burden whereas vitamin D3 promotes β-defensin expression in bovine infectious digital dermatitis.

    abstract::Digital dermatitis (DD), a common ulcerative disease of the bovine foot causing lameness and reducing productivity and animal welfare, is associated with infection by spirochete Treponema bacteria. Topical tetracycline, the most common treatment, has inconsistent cure rates; therefore, new therapeutic options are need...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Watts KM,Lahiri P,Arrazuria R,De Buck J,Knight CG,Orsel K,Barkema HW,Cobo ER

    更新日期:2020-02-01 00:00:00

  • Double homeobox gene, Duxbl, promotes myoblast proliferation and abolishes myoblast differentiation by blocking MyoD transactivation.

    abstract::Homeobox genes encode transcription factors that regulate embryonic development programs including organogenesis, axis formation and limb development. Previously, we identified and cloned a mouse double homeobox gene, Duxbl, whose homeodomain exhibits the highest identity (67 %) to human DUX4, a candidate gene of faci...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Wu SL,Li GZ,Chou CY,Tsai MS,Chen YP,Li CJ,Liou GG,Chang WW,Chen SL,Wang SH

    更新日期:2014-11-01 00:00:00

  • Nitric oxide synthase in the enteric nervous system of the guinea-pig: a quantitative description.

    abstract::The distribution and abundance of nitric oxide synthase (NOS)-containing neurons and their terminals in the gastrointestinal tract of the guinea-pig were examined in detail using NADPH diaphorase histochemistry and NOS immunohistochemistry. NOS-containing cell bodies were found in the myenteric plexus throughout the g...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Furness JB,Li ZS,Young HM,Förstermann U

    更新日期:1994-07-01 00:00:00

  • Immunohistochemical localization of urotensin I and other neuropeptides in the caudal neurosecretory system of three species of teleosts and two species of elasmobranchs.

    abstract::In three species of teleosts - carp Cyprinus carpio; grass carp Ctenopharyngodon idella; and crucian carp Carassius auratus - the caudal neurosecretory system displays small, medium-sized and large neurons. Urotensin I (UI)-immunoreactive and UI-nonreactive neurons were found in all three groups; in general, the numbe...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Yamada C,Yamada S,Ichikawa T,Kobayashi H

    更新日期:1986-01-01 00:00:00

  • Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis.

    abstract::This review focuses on the signaling system involving the Angiopoietin1/Tie2 receptor, which appears to be involved in the secondary stages of blood vessel formation. Although this system is crucial for blood and lymphatic vessel formation, identifying its precise role in embryonic and adult vascular biology has been ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Thurston G

    更新日期:2003-10-01 00:00:00

  • Immunocytochemical studies on the LHRH system of the Japanese quail: influence by photoperiod and aspects of sexual differentiation.

    abstract::Immunocytochemistry was used to determine if photoperiod and/or sex have any effect on the pattern of the luteinizing hormone-releasing hormone (LHRH) system in the brain of the Japanese quail. Immunopositive perikarya were found within three major areas of the brain: the rostral paraolfactory lobe, the preoptic, and ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Foster RG,Panzica GC,Parry DM,Viglietti-Panzica C

    更新日期:1988-08-01 00:00:00

  • Scanning electron microscopic analysis of the linings of the fourth ventricle in the domestic fowl.

    abstract::Surface features of the ependymal linings of the fourth ventricle in the fowl were analyzed employing the scanning electron microscope (SEM). On the floor of the median sulcus, each ependymal cell has a solitary cilium, whereas on both sides of the sulcus, cilia are so densely distributed that the details of the under...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Hirunagi K,Yasuda M

    更新日期:1979-03-09 00:00:00

  • Distribution of neuropeptide F in the ventral nerve cord and its possible role on testicular development and germ cell proliferation in the giant freshwater prawn, Macrobrachium rosenbergii.

    abstract::Neuropeptide F in invertebrates is a homolog of neuropeptide Y in mammals and it is a member of FMRFamide-related peptides. In arthropods, such as insects, there are two types of neuropeptide F comprising long neuropeptide F (NPF) and short neuropeptide F (sNPF). Both NPFs are known to play a crucial role in the regul...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Thongrod S,Wanichanon C,Sobhon P

    更新日期:2019-06-01 00:00:00

  • Immunocytochemical identification of enkephalinergic neurons in the hypothalamic magnocellular preoptic nucleus of the goldfish, Carassius auratus.

    abstract::Our immunocytochemical investigation of the magnocellular neuroendocrine system in the goldfish hypothalamus reveals enkephalin (ENK)-containing neurons interspersed among the vasotocin (VT)- and isotocin (IT)-containing neurons of the preoptic nucleus. The perikarya of the ENK, VT, and IT neurons do not show distinct...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Reaves TA Jr,Hayward JN

    更新日期:1979-08-03 00:00:00

  • Extrarenal determinants of kidney filter function.

    abstract::The kidney is an organ involved in cross talk with many human organs. The link between the immune system and the kidney has been studied in some detail, although data precisely elucidating their interaction are sparse, in particular with regard to the function of the kidney filter apparatus. Current research suggests ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Hahm E,Peev V,Reiser J

    更新日期:2017-07-01 00:00:00

  • The morphology and cell culture of the striated musculature of the rat azygos vein.

    abstract::The azygos vein of the rat can be divided into three regions: The proximal cardiac region, where the wall is composed of two and sometimes three layers of cardiac muscle and a thin discontinuous layer of smooth muscle cells. Vascular casts of this region demonstrate layers of capillaries closely following the orientat...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Cullinan V,Campbell JH,Mosse PR,Campbell GR

    更新日期:1986-01-01 00:00:00

  • Estrogenic stimulation of ovarian follicular maturation in diabetes (db/db) mutant mice: restoration of euglycemia prevents hyperlipidemic cytoatrophy.

    abstract::The diabetes (db/db) mutation (leptin-receptor defect) induces a hyperglycemic-hyperinsulinemic endometabolic environment that promotes hypercytolipidemic ovarian involution in C57BL/KsJ mice, resulting in reproductive sterility and eventual organoatrophy. The effectiveness of low-dose (1.0 microg/sc/3.5 day intervals...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Garris DR

    更新日期:2004-11-01 00:00:00

  • Fine structure of the sensilla of Peripatopsis moseleyi (Onychophora).

    abstract::Three types of sensilla occurring on the lips and on the antennae of Peripatopsis moseleyi have been investigated by scanning and transmission electron microscopy. On the lips sensory spines can be found which contain numerous cilia originating from bipolar receptor cells. They reach the tip of the spine where the cut...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Storch V,Ruhberg H

    更新日期:1977-02-14 00:00:00

  • Neural pathways of olfactory kin imprinting and kin recognition in zebrafish.

    abstract::Teleost fish exhibit extraordinary cognitive skills that are comparable to those of mammals and birds. Kin recognition based on olfactory and visual imprinting requires neuronal circuits that were assumed to be necessarily dependent on the interaction of mammalian amygdala, hippocampus, and isocortex, the latter being...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Gerlach G,Wullimann MF

    更新日期:2021-01-30 00:00:00

  • Efferent neurons of the lateral-line system and the VIII cranial nerve in the brainstem of anurans. A comparative study using retrograde tracer methods.

    abstract::The octavo-lateral efferent system of several anuran species was studied by means of retrograde transport of horseradish peroxidase. This system is organized similarly in all larval anurans and in all adult aglossids. All have two groups of efferent neurons in the nucleus reticularis medialis between the VIIIth and th...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Will U

    更新日期:1982-01-01 00:00:00

  • Desmin in muscle and associated diseases: beyond the structural function.

    abstract::Desmin is a muscle-specific type III intermediate filament essential for proper muscular structure and function. In human, mutations affecting desmin expression or promoting its aggregation lead to skeletal (desmin-related myopathies), or cardiac (desmin-related cardiomyopathy) phenotypes, or both. Patient muscles dis...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Hnia K,Ramspacher C,Vermot J,Laporte J

    更新日期:2015-06-01 00:00:00

  • Male-associated polypeptide (MAP) expression in different compartments of the reproductive system of the mussel Mytilus galloprovincialis: immunocytochemical and western blot study.

    abstract::Mytilus mussels are characterized by annually repeated reproduction which is associated with subsequent growth, morphogenesis, breakdown and redevelopment of the gonad and reproductive tract into mantle mesenchyme. We present a description of the expression of the male-associated polypeptide (MAP; see Mikhailov et al....

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Torrado M,Mikhailov AT

    更新日期:1998-12-01 00:00:00

  • Cellular interconnections in the young mouse ovary. Freeze-fracture study.

    abstract::Intercellular junctions in the young mouse ovary were examined by electron microscopy utilizing freeze-fracture and thin-sectioning techniques. Projections from the granulosa cells adjacent to the oocyte (GI) traverse the zona pellucida and form small gap junctions on the oocyte surface. On the P-face of these cells, ...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Toshimori K,Oura C

    更新日期:1982-01-01 00:00:00

  • The role of EMT in renal fibrosis.

    abstract::It is clear that the well-described phenomenon of epithelial-mesenchymal transition (EMT) plays a pivotal role in embryonic development, wound healing, tissue regeneration, organ fibrosis and cancer progression. EMTs have been classified into three subtypes based on the functional consequences and biomarker context in...

    journal_title:Cell and tissue research

    pub_type: 杂志文章,评审


    authors: Carew RM,Wang B,Kantharidis P

    更新日期:2012-01-01 00:00:00

  • Degeneration of osteoblasts involved in intramembranous ossification of fetal rat calvaria.

    abstract::Ossification of calvariae from day-21 rat fetuses was reinvestigated by electron microscopy using different fixation techniques (glutaraldehyde/OsO4, tannic acid, ruthenium red, K-pyroantimonate). An osteoid layer with scattered mineral deposits was found at the mineralization front. Directly beyond this layer, a shee...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Zimmermann B

    更新日期:1992-01-01 00:00:00

  • A freeze-fracture study of perinatal changes of intramembranous particles in microvilli of absorptive cells in mouse small intestine.

    abstract::Perinatal changes in the appearance of intramembranous particles (IMPs) of microvilli of enterocytes were analyzed quantitatively. In both the jejunum and the ileum, the IMP density on the P-face showed no significant changes from day 17 of gestation to day 5 of postnatal life. It increased between day 5 and day 12, r...

    journal_title:Cell and tissue research

    pub_type: 杂志文章


    authors: Arima T,Yamamoto T

    更新日期:1983-01-01 00:00:00