Abstract:
:Coronary artery disease (CAD) continues to be the most common cause of morbidity and mortality in patients with diabetes mellitus (DM). In recent years, the strategies for treatment of CAD in DM have undergone much evolution. Currently, all patients with DM, regardless of symptoms or diagnosed CAD, are treated aggressively for CAD risk factor reduction. In this clinical climate, the ability to specifically identify patients with disease that will benefit from more aggressive and invasive therapies remains a challenge. In this article we review the current literature on diagnostic and prognostic utility of conventional non-invasive modalities for assessment of CAD in patients with DM, as well as on novel and emerging methods for CAD risk stratification.
journal_name
Rev Endocr Metab Disordjournal_title
Reviews in endocrine & metabolic disordersauthors
Patel NB,Balady GJdoi
10.1007/s11154-010-9129-1subject
Has Abstractpub_date
2010-03-01 00:00:00pages
11-20issue
1eissn
1389-9155issn
1573-2606journal_volume
11pub_type
杂志文章,评审abstract::Abnormalities in thyroid function are common endocrine disorders that affect 5-10 % of the general population, with hypothyroidism occurring more frequently than hyperthyroidism. Clinical symptoms and signs are often nonspecific, particularly in hypothyroidism. Muscular symptoms (stiffness, myalgias, cramps, easy fati...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9357-0
更新日期:2016-12-01 00:00:00
abstract::Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular disease (CVD). One theory to explain this relationship proposes that OSA can induce systemic inflammation, thereby inducing CVD. This theory is based on the premise that obesity is a pro-inflammatory state, and that physiological derange...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-014-9304-x
更新日期:2015-03-01 00:00:00
abstract::With the dramatically increasing prevalence of obesity and type 2 diabetes mellitus (T2DM) worldwide, there is an urgent need for new strategies to combat the growing epidemic of these metabolic diseases. Diet is an essential factor affecting the development of and risk for obesity and T2DM and it can either help or h...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-014-9302-z
更新日期:2015-03-01 00:00:00
abstract::Pituitary tumors are among the most common neoplasms in man; they account for approximately 15% of all primary intracranial lesions (Jagannathan et al., Neurosurg Focus, 19:E4, 2005). Although almost never malignant and rarely clinically expressed, pituitary tumors may cause significant morbidity in affected patients....
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-007-9066-9
更新日期:2008-03-01 00:00:00
abstract::The skeletal muscle is one of the major target organs of insulin and plays an essential role in insulin-induced glucose uptake. Some evidence indicates that insulin delivery to skeletal muscle interstitium through the endothelial cells is the rate-limiting step in insulin-stimulated glucose uptake. Researchers have al...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-013-9242-z
更新日期:2013-06-01 00:00:00
abstract::The term "HCV syndrome" encompasses several organ- and systemic pathophysiological states, which often recognize autoimmunity or neoplastic evolution in their pathophysiology, as well as chronic HCV infection as trigger. The clinical features of HCV patients are heterogenous, and may include endocrine or metabolic dis...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-018-9475-y
更新日期:2018-12-01 00:00:00
abstract::The incidence of neuroendocrine tumors (NET) increases with age. Lately, the diagnosis of NET was mainly caused by early detection of small NET (<1 cm) in the rectum and stomach, which are depicted by chance during routine and prophylactic endoscopy. Also in patients with large and metastatic pancreatic and intestinal...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-018-9469-9
更新日期:2018-06-01 00:00:00
abstract::Diabetes is a group of metabolic disorders characterized by persistent hyperglycemia and has become a major public health concern. Autoimmune type 1 diabetes (T1D) and insulin resistant type 2 diabetes (T2D) are the two main types. A combination of genetic and environmental factors contributes to the development of th...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-015-9309-0
更新日期:2015-03-01 00:00:00
abstract::Despite their critical role in susceptibility to metabolic diseases such as obesity and type 2 diabetes, mechanisms regulating energy balance are extremely complex and far from being fully understood. Both central and peripheral feedback circuits are involved and, despite it was traditionally thought that the energy b...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-020-09565-6
更新日期:2020-09-01 00:00:00
abstract::The incidence of both type 2 and type 1 diabetes mellitus has been increasing worldwide. Vitamin D deficiency, or the awareness of its prevalence, has also been increasing. Vitamin D may have a role in the pathogenic mechanisms predisposing to type 2 diabetes by modulating insulin resistance and/or pancreatic β-cell f...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9403-y
更新日期:2017-06-01 00:00:00
abstract::Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns ...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-018-9477-9
更新日期:2018-12-01 00:00:00
abstract::The last decade has been characterized by an intense research on the composition of the gut microbiome and the links with human health. While previous work was focused on the effects of prebiotics and probiotics, nowadays several laboratories are describing the gut microbiome and its metabolic functions. Gut microbiom...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-019-09533-9
更新日期:2019-12-01 00:00:00
abstract::Prediabetes is a heterogeneous term that encompasses different origins of insulin resistance and insulin secretion that contribute to distinct patterns of hyperglycemia. In fact, prediabetes is an umbrella term that characterizes individuals at high risk for developing type 2 diabetes (T2D) and/or cardiovascular disea...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9352-5
更新日期:2016-03-01 00:00:00
abstract::Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumors, mainly localized in the gastrointestinal system. What characterizes NENs is the expression of hormone receptors on the tumor cell surface, making them accessible for diagnostic and therapeutic approaches (theranostics) using radiolabelled peptid...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-020-09552-x
更新日期:2020-06-03 00:00:00
abstract::From the age of 2 years, an American child is more likely to consume a sugar-sweetened product than a fruit or vegetable on any given day-a troubling statistic, given that food preferences are established early in childhood, as well as the strong association between this dietary pattern and increased risk of developin...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9360-5
更新日期:2016-06-01 00:00:00
abstract::Ectopic Cushing's syndrome usually relates to the ectopic ACTH syndrome (EAS) and represents ∼20% of ACTH-dependent and ∼10% of all types of Cushing's syndrome (CS). Nearly any neuroendocrine or non-endocrine tumours may be associated with EAS, but the more prevalent tumours are bronchial carcinoids, small cell lung c...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-010-9139-z
更新日期:2010-06-01 00:00:00
abstract::Impulsivity and compulsivity are multidimensional constructs that are increasingly considered determinants of obesity. Studies using functional magnetic resonance imaging (fMRI) have provided insight on how differences in brain response during tasks exploring facets of impulsivity and compulsivity relate to the ingest...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-019-09515-x
更新日期:2019-09-01 00:00:00
abstract::New insights on the high prevalence of functional decompensation of the thyroid among newborn and children from several states of India as well as neighbouring countries of Nepal and Bhutan helped to prevent nutritional iodine deficiency and iodine deficiency disorders through country-wide iodized salt prophylaxis. Pr...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-008-9094-0
更新日期:2008-09-01 00:00:00
abstract::In the last 10 years, several studies have shown that the pancreas of patients with type 1 diabetes (T1D), and even of subjects at risk for T1D, was smaller than the pancreas from healthy subjects. This arose the question of the relationships between the endocrine and exocrine parts of the pancreas in T1D pathogenesis...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-019-09501-3
更新日期:2019-06-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders characterized by androgen excess, oligo-ovulation and polycystic ovaries. Although ovaries are the main source of increased androgens in the syndrome, between 20 and 30% of patients with PCOS have adrenal androgen (AA) excess, detectable pr...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-007-9054-0
更新日期:2007-12-01 00:00:00
abstract::A clustering of metabolic abnormalities such as dyslipidemia, hypertension, and diabetes mellitus, all of which are major risk factors for cardiovascular disease (CVD), occurs more often than by chance. Numerous epidemiological studies, as well as basic researches, have revealed that visceral fat accumulation is close...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-014-9294-8
更新日期:2014-12-01 00:00:00
abstract::An emerging branch of research is examining the linkage between Vitamin D and nonskeletal disorders, including endocrine diseases. In this regard, a still little studied aspect concerns the involvement of vitamin D in adrenal gland disorders. Adrenal gland disorders, which might be theoretically affected by vitamin D ...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9391-y
更新日期:2017-09-01 00:00:00
abstract::The ovarian steroid hormones progesterone and estradiol are well established regulators of human endometrial function. However, more recent evidence suggests that androgens and locally generated steroids, such as the glucocorticoids, also have a significant impact on endometrial breakdown and repair. The temporal and ...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-012-9228-2
更新日期:2012-12-01 00:00:00
abstract::Intrauterine growth retardation (IUGR) has been linked to later development of type 2 diabetes in adulthood. Human studies indicate that individuals who were growth retarded at birth have impaired insulin secretion and insulin resistance. Multiple animal models of IUGR demonstrate impaired beta-cell function and devel...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-007-9045-1
更新日期:2007-06-01 00:00:00
abstract::Incretin hormones are intestinally derived peptides that are known to augment glucose-stimulated insulin secretion and suppress glucagon levels. Incretin mimetics are attractive adjunctive therapy for type 2 diabetes due to its efficacy on reducing hyperglycemia with a minimal risk of hypoglycemia. In contrast to most...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-011-9170-8
更新日期:2011-09-01 00:00:00
abstract::Bone health is a major lifelong concern in caring for women and girls with Turner syndrome (TS). There is an approximately 25% increase in fracture risk most of which is related to medium or high impact trauma. The long bones, especially of the forearm are predominantly affected. This fact may be due to a selective co...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-008-9076-2
更新日期:2008-06-01 00:00:00
abstract::Worldwide prevalence of diabetes mellitus in the adult population is increasing and when explicitly searched within specific groups of patients, as those presenting cardiovascular disease (CVD), dysglycaemia is detected in about three-quarters of the patients. Dysglycaemia alone is a major risk factor for microvascula...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-010-9136-2
更新日期:2010-03-01 00:00:00
abstract::Abdominal obesity and elevated blood pressure commonly occur in the same patient and are key components of the metabolic syndrome. However, the association between obesity and increased blood pressure is variable. We review mechanisms linking cardiovascular and metabolic disease in such patients including altered syst...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9348-1
更新日期:2016-03-01 00:00:00
abstract::Diabetes mellitus is a chronic, progressive, incompletely understood metabolic disorder whose prevalence has been increasing steadily worldwide. Even though little attention has been paid to lung disorders in the context of diabetes, its prevalence has recently been challenged by newer studies of disease development. ...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-019-09516-w
更新日期:2019-09-01 00:00:00
abstract::An increasingly pervasive environment of reduced activity and easy access to high caloric food is leading to an epidemic of poor cardiovascular fitness, obesity, insulin resistance and type 2 diabetes (T2DM) in children. Studies have shown that insulin resistance (IR) to be an independent predictor for morbidity as we...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-009-9109-5
更新日期:2009-09-01 00:00:00