Abstract：
:Intrauterine growth retardation (IUGR) has been linked to later development of type 2 diabetes in adulthood. Human studies indicate that individuals who were growth retarded at birth have impaired insulin secretion and insulin resistance. Multiple animal models of IUGR demonstrate impaired beta-cell function and development. We have developed a model of IUGR in the rat that leads to diabetes in adulthood with the salient features of most forms of type 2 diabetes in the human: progressive defects in insulin secretion and insulin action prior to the onset of overt hyperglycemia. Decreased beta-cell proliferation leads to a progressive decline in beta-cell mass. Using this model, we have tested the hypothesis that uteroplacental insufficiency disrupts the function of the electron transport chain in the fetal beta-cell and leads to a debilitating cascade of events: increased production of reactive oxygen species, which in turn damage mitochondrial (mt) mtDNA and causes further production of reactive oxygen species (ROS). The net result is progressive loss of beta-cell function and eventual development of type 2 diabetes in the adult. Studies in the IUGR rat also demonstrate that an abnormal intrauterine environment induces epigenetic modifications of key genes regulating beta-cell development; experiments directly link chromatin remodeling with suppression of transcription. Future research will be directed at elucidating the mechanisms underlying epigenetic modifications in offspring.
journal_name
Rev Endocr Metab Disordjournal_title
Reviews in endocrine & metabolic disordersauthors
Simmons RAdoi
10.1007/s11154-007-9045-1subject
Has Abstractpub_date
2007-06-01 00:00:00pages
95-104issue
2eissn
1389-9155issn
1573-2606journal_volume
8pub_type
杂志文章,评审abstract：:The response to retention hypothesis outlines the initial stages of atherosclerotic lesion formation. The central theme of the hypothesis is that proteoglycan mediated lipoprotein retention plays a critical step in the initiation of atherosclerosis development. Recent research using human arterial specimens, transgeni...
journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
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更新日期：2007-09-01 00:00:00
abstract：:The skeletal muscle is one of the major target organs of insulin and plays an essential role in insulin-induced glucose uptake. Some evidence indicates that insulin delivery to skeletal muscle interstitium through the endothelial cells is the rate-limiting step in insulin-stimulated glucose uptake. Researchers have al...
journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-013-9242-z
更新日期：2013-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-010-9136-2
更新日期：2010-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2008-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-016-9342-7
更新日期：2016-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2016-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-019-09501-3
更新日期：2019-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2015-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2011-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-016-9352-5
更新日期：2016-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-016-9403-y
更新日期：2017-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-016-9391-y
更新日期：2017-09-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-020-09588-z
更新日期：2020-12-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-019-09516-w
更新日期：2019-09-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-012-9215-7
更新日期：2012-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-014-9294-8
更新日期：2014-12-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2009-09-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2010-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2017-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2019-12-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1023/a:1010008318961
更新日期：2000-01-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-007-9072-y
更新日期：2008-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-012-9228-2
更新日期：2012-12-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-016-9348-1
更新日期：2016-03-01 00:00:00
abstract：:Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumors, mainly localized in the gastrointestinal system. What characterizes NENs is the expression of hormone receptors on the tumor cell surface, making them accessible for diagnostic and therapeutic approaches (theranostics) using radiolabelled peptid...
journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-020-09552-x
更新日期：2020-06-03 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-018-9444-5
更新日期：2018-03-01 00:00:00
abstract：:The carcinoid as originally described is part of the relatively large family of neuroendocrine neoplasia found in almost every organ. Historical reasons back their current definitions. Neuroendocrine cancer is most frequently observed in the lung and the digestive tract. In the lung is defined as carcinoid (typical an...
journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-017-9428-x
更新日期：2017-12-01 00:00:00
abstract：:Adiponectin is among the most studied adipokines, the collection of molecules secreted from adipose tissue. It is also one of the most architecturally complex adipokines with its various oligomeric states that include trimers, hexamers, nonamers (9mers), dodecamers (12mers), and octadecamers (18mers). The importance o...
journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-013-9256-6
更新日期：2014-06-01 00:00:00
