Cardiometabolic crosstalk in obesity-associated arterial hypertension.

abstract：:The ATP-sensitive potassium (K(ATP)) channel is composed of two subunits SUR1 and Kir6.2. The channel is key for glucose stimulated insulin release from the pancreatic beta cell. Activating mutations have been identified in the genes encoding these subunits, ABCC8 and KCNJ11, and account for approximately 40% of perma...

journal_title：Reviews in endocrine & metabolic disorders

authors： Edghill EL,Flanagan SE,Ellard S

更新日期：2010-09-01 00:00:00

abstract：:Coronary artery disease (CAD) continues to be the most common cause of morbidity and mortality in patients with diabetes mellitus (DM). In recent years, the strategies for treatment of CAD in DM have undergone much evolution. Currently, all patients with DM, regardless of symptoms or diagnosed CAD, are treated aggress...

journal_title：Reviews in endocrine & metabolic disorders

authors： Patel NB,Balady GJ

更新日期：2010-03-01 00:00:00

abstract：:The response to retention hypothesis outlines the initial stages of atherosclerotic lesion formation. The central theme of the hypothesis is that proteoglycan mediated lipoprotein retention plays a critical step in the initiation of atherosclerosis development. Recent research using human arterial specimens, transgeni...

journal_title：Reviews in endocrine & metabolic disorders

authors： Tannock LR,King VL

更新日期：2008-12-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders characterized by androgen excess, oligo-ovulation and polycystic ovaries. Although ovaries are the main source of increased androgens in the syndrome, between 20 and 30% of patients with PCOS have adrenal androgen (AA) excess, detectable pr...

journal_title：Reviews in endocrine & metabolic disorders

authors： Yildiz BO,Azziz R

更新日期：2007-12-01 00:00:00

abstract：:Glucokinase is a key enzyme involved in regulating insulin secretion from the pancreatic ß-cell. The unique role of glucokinase in human glucose physiology is illustrated by the fact that genetic mutations in glucokinase can either cause hyperglycaemia or hypoglycaemia. Heterozygous inactivating mutations in glucokina...

journal_title：Reviews in endocrine & metabolic disorders

authors： Hussain K

更新日期：2010-09-01 00:00:00

abstract：:Adiponectin is among the most studied adipokines, the collection of molecules secreted from adipose tissue. It is also one of the most architecturally complex adipokines with its various oligomeric states that include trimers, hexamers, nonamers (9mers), dodecamers (12mers), and octadecamers (18mers). The importance o...

journal_title：Reviews in endocrine & metabolic disorders

authors： Tsao TS

更新日期：2014-06-01 00:00:00

abstract：:Diabetes mellitus is a chronic, progressive, incompletely understood metabolic disorder whose prevalence has been increasing steadily worldwide. Even though little attention has been paid to lung disorders in the context of diabetes, its prevalence has recently been challenged by newer studies of disease development. ...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kolahian S,Leiss V,Nürnberg B

更新日期：2019-09-01 00:00:00

abstract：:T3 suppression of TSH subunit gene transcription is an important step in maintaining thyroid hormone homeostasis, and recent investigations have increased our understanding of this process. Thyrotrope-specific proteins play a critical role in TSH subunit gene expression, and influence T3-mediated regulatory mechanisms...

journal_title：Reviews in endocrine & metabolic disorders

authors： Shupnik MA

更新日期：2000-01-01 00:00:00

abstract：:Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kalhan SC,Marczewski SE

更新日期：2012-06-01 00:00:00

abstract：:The ovarian steroid hormones progesterone and estradiol are well established regulators of human endometrial function. However, more recent evidence suggests that androgens and locally generated steroids, such as the glucocorticoids, also have a significant impact on endometrial breakdown and repair. The temporal and ...

journal_title：Reviews in endocrine & metabolic disorders

authors： Maybin JA,Critchley HO

更新日期：2012-12-01 00:00:00

abstract：:The peak in incidence for schizophrenia is during late adolescence for both sexes, but within this time frame the peak is both earlier and steeper for males. Additionally, women have a second peak in incidence following menopause. Two meta-analyses have reported that men have an overall ∼40% greater chance of developi...

journal_title：Reviews in endocrine & metabolic disorders

authors： Markham JA

更新日期：2012-09-01 00:00:00

abstract：:Ectopic Cushing's syndrome usually relates to the ectopic ACTH syndrome (EAS) and represents ∼20% of ACTH-dependent and ∼10% of all types of Cushing's syndrome (CS). Nearly any neuroendocrine or non-endocrine tumours may be associated with EAS, but the more prevalent tumours are bronchial carcinoids, small cell lung c...

journal_title：Reviews in endocrine & metabolic disorders

authors： Alexandraki KI,Grossman AB

更新日期：2010-06-01 00:00:00

abstract：:Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns ...

journal_title：Reviews in endocrine & metabolic disorders

authors： Fallahi P,Ferrari SM,Elia G,Ragusa F,Paparo SR,Caruso C,Guglielmi G,Antonelli A

更新日期：2018-12-01 00:00:00

abstract：UNLABELLED:We aimed to review and summarize the evidence from accomplished trials analyzing factors influencing mortality in patients with T2DM and to provide some recommendations for targets and treatment in the European region. The following databases were searched for relevant trials: PubMed and the Cochrane Library...

journal_title：Reviews in endocrine & metabolic disorders

authors： Engelmann J,Manuwald U,Rubach C,Kugler J,Birkenfeld AL,Hanefeld M,Rothe U

更新日期：2016-03-01 00:00:00

abstract：:Despite their critical role in susceptibility to metabolic diseases such as obesity and type 2 diabetes, mechanisms regulating energy balance are extremely complex and far from being fully understood. Both central and peripheral feedback circuits are involved and, despite it was traditionally thought that the energy b...

journal_title：Reviews in endocrine & metabolic disorders

authors： Vettor R,Di Vincenzo A,Maffei P,Rossato M

更新日期：2020-09-01 00:00:00

abstract：:Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumors, mainly localized in the gastrointestinal system. What characterizes NENs is the expression of hormone receptors on the tumor cell surface, making them accessible for diagnostic and therapeutic approaches (theranostics) using radiolabelled peptid...

journal_title：Reviews in endocrine & metabolic disorders

authors： Refardt J,Hofland J,Kwadwo A,Nicolas GP,Rottenburger C,Fani M,Wild D,Christ E

更新日期：2020-06-03 00:00:00

abstract：:A clustering of metabolic abnormalities such as dyslipidemia, hypertension, and diabetes mellitus, all of which are major risk factors for cardiovascular disease (CVD), occurs more often than by chance. Numerous epidemiological studies, as well as basic researches, have revealed that visceral fat accumulation is close...

journal_title：Reviews in endocrine & metabolic disorders

authors： Takahara M,Shimomura I

更新日期：2014-12-01 00:00:00

abstract：:Celiac disease is a chronic enteropathy caused by permanent intolerance to gluten and similar proteins found in wheat, barley and rye. The intestinal mucosa of susceptible individuals is crossed by undigested gluten, which leads to a marked inflammatory response. The clinical features may vary from overt intestinal sy...

journal_title：Reviews in endocrine & metabolic disorders

authors： Mora S

更新日期：2008-06-01 00:00:00

abstract：:Incretin hormones are intestinally derived peptides that are known to augment glucose-stimulated insulin secretion and suppress glucagon levels. Incretin mimetics are attractive adjunctive therapy for type 2 diabetes due to its efficacy on reducing hyperglycemia with a minimal risk of hypoglycemia. In contrast to most...

journal_title：Reviews in endocrine & metabolic disorders

authors： Tong J,Sandoval DA

更新日期：2011-09-01 00:00:00

abstract：:The last decade has been characterized by an intense research on the composition of the gut microbiome and the links with human health. While previous work was focused on the effects of prebiotics and probiotics, nowadays several laboratories are describing the gut microbiome and its metabolic functions. Gut microbiom...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kappel BA,Federici M

更新日期：2019-12-01 00:00:00

abstract：:The vascular endothelium has been identified as an important component in diabetes-associated complications, which include many cardiovascular disorders such as atherosclerosis, hypertension and peripheral neuropathy. Additionally, insulin's actions on the endothelium are now seen as a major factor in the metabolic ef...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kolka CM,Bergman RN

更新日期：2013-03-01 00:00:00

abstract：:The carcinoid as originally described is part of the relatively large family of neuroendocrine neoplasia found in almost every organ. Historical reasons back their current definitions. Neuroendocrine cancer is most frequently observed in the lung and the digestive tract. In the lung is defined as carcinoid (typical an...

journal_title：Reviews in endocrine & metabolic disorders

authors： Inzani F,Petrone G,Fadda G,Rindi G

更新日期：2017-12-01 00:00:00

abstract：:From the age of 2 years, an American child is more likely to consume a sugar-sweetened product than a fruit or vegetable on any given day-a troubling statistic, given that food preferences are established early in childhood, as well as the strong association between this dietary pattern and increased risk of developin...

journal_title：Reviews in endocrine & metabolic disorders

authors： Mennella JA,Bobowski NK,Reed DR

更新日期：2016-06-01 00:00:00

abstract：:The term "HCV syndrome" encompasses several organ- and systemic pathophysiological states, which often recognize autoimmunity or neoplastic evolution in their pathophysiology, as well as chronic HCV infection as trigger. The clinical features of HCV patients are heterogenous, and may include endocrine or metabolic dis...

journal_title：Reviews in endocrine & metabolic disorders

authors： Colaci M,Malatino L,Antonelli A,Fallahi P,Giuggioli D,Ferri C

更新日期：2018-12-01 00:00:00

abstract：:The prevalence of convenience-driven delivery via Caesarian-section (C-section) has been steadily increasing in Western as well as in developing societies. Today, significantly more deliveries occur via surgical means than medical necessity mandates. Despite tremendous advances in surgical techniques and pre- and post...

journal_title：Reviews in endocrine & metabolic disorders

authors： Seli E,Horvath TL

更新日期：2013-12-01 00:00:00

abstract：:The adipose tissue (AT) is multifunctional, acting as an endocrine tissue and participating in the regulation of the organism's homeostasis. Metabolic, endocrine and inflammatory mechanisms are tightly intertwined within the AT, regulating its function. Disruption of the equilibrium among these mechanisms leads to pat...

journal_title：Reviews in endocrine & metabolic disorders

authors： Alexaki VI,Chavakis T

更新日期：2016-03-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular disease (CVD). One theory to explain this relationship proposes that OSA can induce systemic inflammation, thereby inducing CVD. This theory is based on the premise that obesity is a pro-inflammatory state, and that physiological derange...

journal_title：Reviews in endocrine & metabolic disorders

authors： Unnikrishnan D,Jun J,Polotsky V

更新日期：2015-03-01 00:00:00

abstract：:An increasingly pervasive environment of reduced activity and easy access to high caloric food is leading to an epidemic of poor cardiovascular fitness, obesity, insulin resistance and type 2 diabetes (T2DM) in children. Studies have shown that insulin resistance (IR) to be an independent predictor for morbidity as we...

journal_title：Reviews in endocrine & metabolic disorders

authors： Carrel AL,Allen DB

更新日期：2009-09-01 00:00:00

abstract：:Deleterious mutations in two breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2 have been identified in breast and ovarian cancer families. Women with a BRCA1 or BRCA2 mutation are candidates for additional risk reduction measures such as intensive screening, prophylactic surgery or chemoprevention. Addit...

journal_title：Reviews in endocrine & metabolic disorders

authors： Bradbury AR,Olopade OI

更新日期：2007-09-01 00:00:00

abstract：:Pituitary tumors are among the most common neoplasms in man; they account for approximately 15% of all primary intracranial lesions (Jagannathan et al., Neurosurg Focus, 19:E4, 2005). Although almost never malignant and rarely clinically expressed, pituitary tumors may cause significant morbidity in affected patients....

journal_title：Reviews in endocrine & metabolic disorders

authors： Horvath A,Stratakis CA

更新日期：2008-03-01 00:00:00