abstract：:The 13th Acromegaly Consensus Conference was held in November 2019 in Fort Lauderdale, Florida, and comprised acromegaly experts including endocrinologists and neurosurgeons who considered optimal approaches for multidisciplinary acromegaly management. Focused discussions reviewed techniques, results, and side effects...

journal_title：Reviews in endocrine & metabolic disorders

authors： Giustina A,Barkhoudarian G,Beckers A,Ben-Shlomo A,Biermasz N,Biller B,Boguszewski C,Bolanowski M,Bollerslev J,Bonert V,Bronstein MD,Buchfelder M,Casanueva F,Chanson P,Clemmons D,Fleseriu M,Formenti AM,Freda P,Gadelha

更新日期：2020-12-01 00:00:00

abstract：:Despite their critical role in susceptibility to metabolic diseases such as obesity and type 2 diabetes, mechanisms regulating energy balance are extremely complex and far from being fully understood. Both central and peripheral feedback circuits are involved and, despite it was traditionally thought that the energy b...

journal_title：Reviews in endocrine & metabolic disorders

authors： Vettor R,Di Vincenzo A,Maffei P,Rossato M

更新日期：2020-09-01 00:00:00

abstract：:Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumors, mainly localized in the gastrointestinal system. What characterizes NENs is the expression of hormone receptors on the tumor cell surface, making them accessible for diagnostic and therapeutic approaches (theranostics) using radiolabelled peptid...

journal_title：Reviews in endocrine & metabolic disorders

authors： Refardt J,Hofland J,Kwadwo A,Nicolas GP,Rottenburger C,Fani M,Wild D,Christ E

更新日期：2020-06-03 00:00:00

abstract：:The last decade has been characterized by an intense research on the composition of the gut microbiome and the links with human health. While previous work was focused on the effects of prebiotics and probiotics, nowadays several laboratories are describing the gut microbiome and its metabolic functions. Gut microbiom...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kappel BA,Federici M

更新日期：2019-12-01 00:00:00

abstract：:Diabetes mellitus is a chronic, progressive, incompletely understood metabolic disorder whose prevalence has been increasing steadily worldwide. Even though little attention has been paid to lung disorders in the context of diabetes, its prevalence has recently been challenged by newer studies of disease development. ...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kolahian S,Leiss V,Nürnberg B

更新日期：2019-09-01 00:00:00

abstract：:Impulsivity and compulsivity are multidimensional constructs that are increasingly considered determinants of obesity. Studies using functional magnetic resonance imaging (fMRI) have provided insight on how differences in brain response during tasks exploring facets of impulsivity and compulsivity relate to the ingest...

journal_title：Reviews in endocrine & metabolic disorders

authors： Steward T,Miranda-Olivos R,Soriano-Mas C,Fernández-Aranda F

更新日期：2019-09-01 00:00:00

abstract：:Weight gain at the outset of prolactinomas in many women is well documented. Yet, this symptom is absent from the clinical descriptions of the disease in textbooks and reviews. This omission is almost certainly due to the absence of a physiological explanation for the phenomenon, as prolactin is not a recognized fat p...

journal_title：Reviews in endocrine & metabolic disorders

authors： Sobrinho LG,Horseman ND

更新日期：2019-06-01 00:00:00

abstract：:In the last 10 years, several studies have shown that the pancreas of patients with type 1 diabetes (T1D), and even of subjects at risk for T1D, was smaller than the pancreas from healthy subjects. This arose the question of the relationships between the endocrine and exocrine parts of the pancreas in T1D pathogenesis...

journal_title：Reviews in endocrine & metabolic disorders

authors： Alexandre-Heymann L,Mallone R,Boitard C,Scharfmann R,Larger E

更新日期：2019-06-01 00:00:00

abstract：:Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns ...

journal_title：Reviews in endocrine & metabolic disorders

authors： Fallahi P,Ferrari SM,Elia G,Ragusa F,Paparo SR,Caruso C,Guglielmi G,Antonelli A

更新日期：2018-12-01 00:00:00

abstract：:The term "HCV syndrome" encompasses several organ- and systemic pathophysiological states, which often recognize autoimmunity or neoplastic evolution in their pathophysiology, as well as chronic HCV infection as trigger. The clinical features of HCV patients are heterogenous, and may include endocrine or metabolic dis...

journal_title：Reviews in endocrine & metabolic disorders

authors： Colaci M,Malatino L,Antonelli A,Fallahi P,Giuggioli D,Ferri C

更新日期：2018-12-01 00:00:00

abstract：:The incidence of neuroendocrine tumors (NET) increases with age. Lately, the diagnosis of NET was mainly caused by early detection of small NET (<1 cm) in the rectum and stomach, which are depicted by chance during routine and prophylactic endoscopy. Also in patients with large and metastatic pancreatic and intestinal...

journal_title：Reviews in endocrine & metabolic disorders

authors： Goretzki PE,Mogl MT,Akca A,Pratschke J

更新日期：2018-06-01 00:00:00

abstract：:The adult endocrinologist may be asked to consult on a patient for unexplained biochemical disturbances that could be caused by an underlying inborn error of metabolism. A genetic disorder is generally less likely to be the cause as these disorders are individually rare, however inborn errors of metabolism are collect...

journal_title：Reviews in endocrine & metabolic disorders

authors： Tchan M

更新日期：2018-03-01 00:00:00

abstract：:The carcinoid as originally described is part of the relatively large family of neuroendocrine neoplasia found in almost every organ. Historical reasons back their current definitions. Neuroendocrine cancer is most frequently observed in the lung and the digestive tract. In the lung is defined as carcinoid (typical an...

journal_title：Reviews in endocrine & metabolic disorders

authors： Inzani F,Petrone G,Fadda G,Rindi G

更新日期：2017-12-01 00:00:00

abstract：:An emerging branch of research is examining the linkage between Vitamin D and nonskeletal disorders, including endocrine diseases. In this regard, a still little studied aspect concerns the involvement of vitamin D in adrenal gland disorders. Adrenal gland disorders, which might be theoretically affected by vitamin D ...

journal_title：Reviews in endocrine & metabolic disorders

authors： Tirabassi G,Salvio G,Altieri B,Ronchi CL,Della Casa S,Pontecorvi A,Balercia G

更新日期：2017-09-01 00:00:00

abstract：:The incidence of both type 2 and type 1 diabetes mellitus has been increasing worldwide. Vitamin D deficiency, or the awareness of its prevalence, has also been increasing. Vitamin D may have a role in the pathogenic mechanisms predisposing to type 2 diabetes by modulating insulin resistance and/or pancreatic β-cell f...

journal_title：Reviews in endocrine & metabolic disorders

authors： Grammatiki M,Rapti E,Karras S,Ajjan RA,Kotsa K

更新日期：2017-06-01 00:00:00

abstract：:Vitamin D is a key hormone involved in the regulation of calcium/phosphorous balance and recently it has been implicated in the pathogenesis of sub-inflammation, insulin resistance and obesity. The two main forms of vitamin D are cholecalciferol (Vitamin D3) and ergocalciferol (Vitamin D2): the active form (1,25-dihyd...

journal_title：Reviews in endocrine & metabolic disorders

authors： Garbossa SG,Folli F

更新日期：2017-06-01 00:00:00

abstract：:Abnormalities in thyroid function are common endocrine disorders that affect 5-10 % of the general population, with hypothyroidism occurring more frequently than hyperthyroidism. Clinical symptoms and signs are often nonspecific, particularly in hypothyroidism. Muscular symptoms (stiffness, myalgias, cramps, easy fati...

journal_title：Reviews in endocrine & metabolic disorders

authors： Sindoni A,Rodolico C,Pappalardo MA,Portaro S,Benvenga S

更新日期：2016-12-01 00:00:00

abstract：:From the age of 2 years, an American child is more likely to consume a sugar-sweetened product than a fruit or vegetable on any given day-a troubling statistic, given that food preferences are established early in childhood, as well as the strong association between this dietary pattern and increased risk of developin...

journal_title：Reviews in endocrine & metabolic disorders

authors： Mennella JA,Bobowski NK,Reed DR

更新日期：2016-06-01 00:00:00

abstract：UNLABELLED:We aimed to review and summarize the evidence from accomplished trials analyzing factors influencing mortality in patients with T2DM and to provide some recommendations for targets and treatment in the European region. The following databases were searched for relevant trials: PubMed and the Cochrane Library...

journal_title：Reviews in endocrine & metabolic disorders

authors： Engelmann J,Manuwald U,Rubach C,Kugler J,Birkenfeld AL,Hanefeld M,Rothe U

更新日期：2016-03-01 00:00:00

abstract：:The adipose tissue (AT) is multifunctional, acting as an endocrine tissue and participating in the regulation of the organism's homeostasis. Metabolic, endocrine and inflammatory mechanisms are tightly intertwined within the AT, regulating its function. Disruption of the equilibrium among these mechanisms leads to pat...

journal_title：Reviews in endocrine & metabolic disorders

authors： Alexaki VI,Chavakis T

更新日期：2016-03-01 00:00:00

abstract：:Prediabetes is a heterogeneous term that encompasses different origins of insulin resistance and insulin secretion that contribute to distinct patterns of hyperglycemia. In fact, prediabetes is an umbrella term that characterizes individuals at high risk for developing type 2 diabetes (T2D) and/or cardiovascular disea...

journal_title：Reviews in endocrine & metabolic disorders

authors： Malin SK,Liu Z,Barrett EJ,Weltman A

更新日期：2016-03-01 00:00:00

abstract：:Abdominal obesity and elevated blood pressure commonly occur in the same patient and are key components of the metabolic syndrome. However, the association between obesity and increased blood pressure is variable. We review mechanisms linking cardiovascular and metabolic disease in such patients including altered syst...

journal_title：Reviews in endocrine & metabolic disorders

authors： Jordan J,Birkenfeld AL

更新日期：2016-03-01 00:00:00

abstract：:Diabetes is a group of metabolic disorders characterized by persistent hyperglycemia and has become a major public health concern. Autoimmune type 1 diabetes (T1D) and insulin resistant type 2 diabetes (T2D) are the two main types. A combination of genetic and environmental factors contributes to the development of th...

journal_title：Reviews in endocrine & metabolic disorders

authors： Tai N,Wong FS,Wen L

更新日期：2015-03-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular disease (CVD). One theory to explain this relationship proposes that OSA can induce systemic inflammation, thereby inducing CVD. This theory is based on the premise that obesity is a pro-inflammatory state, and that physiological derange...

journal_title：Reviews in endocrine & metabolic disorders

authors： Unnikrishnan D,Jun J,Polotsky V

更新日期：2015-03-01 00:00:00

abstract：:With the dramatically increasing prevalence of obesity and type 2 diabetes mellitus (T2DM) worldwide, there is an urgent need for new strategies to combat the growing epidemic of these metabolic diseases. Diet is an essential factor affecting the development of and risk for obesity and T2DM and it can either help or h...

journal_title：Reviews in endocrine & metabolic disorders

authors： Guo H,Ling W

更新日期：2015-03-01 00:00:00

abstract：:A clustering of metabolic abnormalities such as dyslipidemia, hypertension, and diabetes mellitus, all of which are major risk factors for cardiovascular disease (CVD), occurs more often than by chance. Numerous epidemiological studies, as well as basic researches, have revealed that visceral fat accumulation is close...

journal_title：Reviews in endocrine & metabolic disorders

authors： Takahara M,Shimomura I

更新日期：2014-12-01 00:00:00

abstract：:Adiponectin is among the most studied adipokines, the collection of molecules secreted from adipose tissue. It is also one of the most architecturally complex adipokines with its various oligomeric states that include trimers, hexamers, nonamers (9mers), dodecamers (12mers), and octadecamers (18mers). The importance o...

journal_title：Reviews in endocrine & metabolic disorders

authors： Tsao TS

更新日期：2014-06-01 00:00:00

abstract：:The prevalence of convenience-driven delivery via Caesarian-section (C-section) has been steadily increasing in Western as well as in developing societies. Today, significantly more deliveries occur via surgical means than medical necessity mandates. Despite tremendous advances in surgical techniques and pre- and post...

journal_title：Reviews in endocrine & metabolic disorders

authors： Seli E,Horvath TL

更新日期：2013-12-01 00:00:00

abstract：:Lifestyle changes such as dietary habits, sedentary life and consumption of energy-dense foods that have occurred over the years has led to an epidemic of abdominal obesity, which in turn resulted in dramatic increase in the prevalence of metabolic syndrome (MetS). Different expert panels have provided various definit...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kumar PA,Chitra PS,Reddy GB

更新日期：2013-09-01 00:00:00

abstract：:The skeletal muscle is one of the major target organs of insulin and plays an essential role in insulin-induced glucose uptake. Some evidence indicates that insulin delivery to skeletal muscle interstitium through the endothelial cells is the rate-limiting step in insulin-stimulated glucose uptake. Researchers have al...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kubota T,Kubota N,Kadowaki T

更新日期：2013-06-01 00:00:00

abstract：:The hypothalamic pituitary adrenal (HPA) axis is the most common of the endocrine lines/axis' to be affected by HIV infection. There are multiple factors that contribute to this HPA axis dysregulation. Direct invasion of the various organs in the axis can be either by opportunistic infections or infiltrative diseases....

journal_title：Reviews in endocrine & metabolic disorders

authors： George MM,Bhangoo A

更新日期：2013-06-01 00:00:00

abstract：:Endothelial dysfunction associated with diabetes and cardiovascular disease is characterized by changes in vasoregulation, enhanced generation of reactive oxygen intermediates, inflammatory activation, and altered barrier function. These endothelial alterations contribute to excess cardiovascular disease in diabetes, ...

journal_title：Reviews in endocrine & metabolic disorders

authors： Eringa EC,Serne EH,Meijer RI,Schalkwijk CG,Houben AJ,Stehouwer CD,Smulders YM,van Hinsbergh VW

更新日期：2013-03-01 00:00:00

abstract：:The vascular endothelium has been identified as an important component in diabetes-associated complications, which include many cardiovascular disorders such as atherosclerosis, hypertension and peripheral neuropathy. Additionally, insulin's actions on the endothelium are now seen as a major factor in the metabolic ef...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kolka CM,Bergman RN

更新日期：2013-03-01 00:00:00

abstract：:The ovarian steroid hormones progesterone and estradiol are well established regulators of human endometrial function. However, more recent evidence suggests that androgens and locally generated steroids, such as the glucocorticoids, also have a significant impact on endometrial breakdown and repair. The temporal and ...

journal_title：Reviews in endocrine & metabolic disorders

authors： Maybin JA,Critchley HO

更新日期：2012-12-01 00:00:00

abstract：:The peak in incidence for schizophrenia is during late adolescence for both sexes, but within this time frame the peak is both earlier and steeper for males. Additionally, women have a second peak in incidence following menopause. Two meta-analyses have reported that men have an overall ∼40% greater chance of developi...

journal_title：Reviews in endocrine & metabolic disorders

authors： Markham JA

更新日期：2012-09-01 00:00:00

abstract：:Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kalhan SC,Marczewski SE

更新日期：2012-06-01 00:00:00

abstract：:Incretin hormones are intestinally derived peptides that are known to augment glucose-stimulated insulin secretion and suppress glucagon levels. Incretin mimetics are attractive adjunctive therapy for type 2 diabetes due to its efficacy on reducing hyperglycemia with a minimal risk of hypoglycemia. In contrast to most...

journal_title：Reviews in endocrine & metabolic disorders

authors： Tong J,Sandoval DA

更新日期：2011-09-01 00:00:00

abstract：:This paper provides evidence that primary aldosteronism is likely much less common than is believed by the other authors of this collection. The basis for this contrarian view is simple: there is no way to know the true prevalence of PA because of the uncertain validity of all of the diagnostic procedures used to find...

journal_title：Reviews in endocrine & metabolic disorders

authors： Kaplan NM

更新日期：2011-03-01 00:00:00

abstract：:It is widely acknowledged that compliance and persistence with oral osteoporosis medications, particularly with bisphosphonates, is poor. Several excellent reviews have been written on compliance and persistence with osteoporosis medications and have discussed improvements seen with extended dosing intervals. This rev...

journal_title：Reviews in endocrine & metabolic disorders

authors： Silverman S,Gold DT

更新日期：2010-12-01 00:00:00

abstract：:Glucokinase is a key enzyme involved in regulating insulin secretion from the pancreatic ß-cell. The unique role of glucokinase in human glucose physiology is illustrated by the fact that genetic mutations in glucokinase can either cause hyperglycaemia or hypoglycaemia. Heterozygous inactivating mutations in glucokina...

journal_title：Reviews in endocrine & metabolic disorders

authors： Hussain K

更新日期：2010-09-01 00:00:00