Abstract:
:Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular disease (CVD). One theory to explain this relationship proposes that OSA can induce systemic inflammation, thereby inducing CVD. This theory is based on the premise that obesity is a pro-inflammatory state, and that physiological derangements during sleep in subjects with OSA further aggravate inflammation. In support of this theory, some clinical studies have shown elevated inflammatory biomarkers in OSA subjects, or improvement in these markers following treatment of OSA. However, the data are inconsistent and often confounded by the effects of comorbid obesity. Animal models of OSA have been developed, which involve exposure of rodents or cells to intermittent hypoxia, a hallmark feature of OSA. Several of these experiments demonstrate that intermittent hypoxia can stimulate inflammatory pathways and lead to cardiovascular or metabolic pathology. In this review, we review relationships between OSA and inflammation, with particular attention to studies published within the last year.
journal_name
Rev Endocr Metab Disordjournal_title
Reviews in endocrine & metabolic disordersauthors
Unnikrishnan D,Jun J,Polotsky Vdoi
10.1007/s11154-014-9304-xsubject
Has Abstractpub_date
2015-03-01 00:00:00pages
25-34issue
1eissn
1389-9155issn
1573-2606journal_volume
16pub_type
杂志文章,评审abstract::Impulsivity and compulsivity are multidimensional constructs that are increasingly considered determinants of obesity. Studies using functional magnetic resonance imaging (fMRI) have provided insight on how differences in brain response during tasks exploring facets of impulsivity and compulsivity relate to the ingest...
journal_title:Reviews in endocrine & metabolic disorders
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journal_title:Reviews in endocrine & metabolic disorders
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journal_title:Reviews in endocrine & metabolic disorders
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journal_title:Reviews in endocrine & metabolic disorders
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doi:10.1007/s11154-007-9066-9
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-013-9268-2
更新日期:2013-09-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-019-09533-9
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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更新日期:2016-03-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-06-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-013-9239-7
更新日期:2013-03-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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更新日期:2008-06-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-011-9184-2
更新日期:2012-09-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9349-0
更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s11154-007-9072-y
更新日期:2008-06-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-012-9215-7
更新日期:2012-06-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-019-09516-w
更新日期:2019-09-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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journal_title:Reviews in endocrine & metabolic disorders
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journal_title:Reviews in endocrine & metabolic disorders
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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journal_title:Reviews in endocrine & metabolic disorders
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journal_title:Reviews in endocrine & metabolic disorders
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pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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journal_title:Reviews in endocrine & metabolic disorders
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更新日期:2013-06-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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更新日期:2008-06-01 00:00:00
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journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
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