Abstract:
:This paper provides evidence that primary aldosteronism is likely much less common than is believed by the other authors of this collection. The basis for this contrarian view is simple: there is no way to know the true prevalence of PA because of the uncertain validity of all of the diagnostic procedures used to find and characterize this disease. Moreover, even if these uncertainties are overcome, the eventual treatment of most who have PA can be provided without the need for extensive testing and expensive treatment.
journal_name
Rev Endocr Metab Disordjournal_title
Reviews in endocrine & metabolic disordersauthors
Kaplan NMdoi
10.1007/s11154-011-9160-xsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
49-52issue
1eissn
1389-9155issn
1573-2606journal_volume
12pub_type
杂志文章,评审abstract::Pituitary tumors are among the most common neoplasms in man; they account for approximately 15% of all primary intracranial lesions (Jagannathan et al., Neurosurg Focus, 19:E4, 2005). Although almost never malignant and rarely clinically expressed, pituitary tumors may cause significant morbidity in affected patients....
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-007-9066-9
更新日期:2008-03-01 00:00:00
abstract::The adult endocrinologist may be asked to consult on a patient for unexplained biochemical disturbances that could be caused by an underlying inborn error of metabolism. A genetic disorder is generally less likely to be the cause as these disorders are individually rare, however inborn errors of metabolism are collect...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-018-9444-5
更新日期:2018-03-01 00:00:00
abstract::Worldwide prevalence of diabetes mellitus in the adult population is increasing and when explicitly searched within specific groups of patients, as those presenting cardiovascular disease (CVD), dysglycaemia is detected in about three-quarters of the patients. Dysglycaemia alone is a major risk factor for microvascula...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-010-9136-2
更新日期:2010-03-01 00:00:00
abstract::Incretin hormones are intestinally derived peptides that are known to augment glucose-stimulated insulin secretion and suppress glucagon levels. Incretin mimetics are attractive adjunctive therapy for type 2 diabetes due to its efficacy on reducing hyperglycemia with a minimal risk of hypoglycemia. In contrast to most...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-011-9170-8
更新日期:2011-09-01 00:00:00
abstract::T3 suppression of TSH subunit gene transcription is an important step in maintaining thyroid hormone homeostasis, and recent investigations have increased our understanding of this process. Thyrotrope-specific proteins play a critical role in TSH subunit gene expression, and influence T3-mediated regulatory mechanisms...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1023/a:1010008318961
更新日期:2000-01-01 00:00:00
abstract::The adipose tissue (AT) is multifunctional, acting as an endocrine tissue and participating in the regulation of the organism's homeostasis. Metabolic, endocrine and inflammatory mechanisms are tightly intertwined within the AT, regulating its function. Disruption of the equilibrium among these mechanisms leads to pat...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9342-7
更新日期:2016-03-01 00:00:00
abstract::From the age of 2 years, an American child is more likely to consume a sugar-sweetened product than a fruit or vegetable on any given day-a troubling statistic, given that food preferences are established early in childhood, as well as the strong association between this dietary pattern and increased risk of developin...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9360-5
更新日期:2016-06-01 00:00:00
abstract::With the dramatically increasing prevalence of obesity and type 2 diabetes mellitus (T2DM) worldwide, there is an urgent need for new strategies to combat the growing epidemic of these metabolic diseases. Diet is an essential factor affecting the development of and risk for obesity and T2DM and it can either help or h...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-014-9302-z
更新日期:2015-03-01 00:00:00
abstract::Diabetes mellitus is a chronic, progressive, incompletely understood metabolic disorder whose prevalence has been increasing steadily worldwide. Even though little attention has been paid to lung disorders in the context of diabetes, its prevalence has recently been challenged by newer studies of disease development. ...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-019-09516-w
更新日期:2019-09-01 00:00:00
abstract::Bone health is a major lifelong concern in caring for women and girls with Turner syndrome (TS). There is an approximately 25% increase in fracture risk most of which is related to medium or high impact trauma. The long bones, especially of the forearm are predominantly affected. This fact may be due to a selective co...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-008-9076-2
更新日期:2008-06-01 00:00:00
abstract::The vascular endothelium has been identified as an important component in diabetes-associated complications, which include many cardiovascular disorders such as atherosclerosis, hypertension and peripheral neuropathy. Additionally, insulin's actions on the endothelium are now seen as a major factor in the metabolic ef...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-012-9233-5
更新日期:2013-03-01 00:00:00
abstract::Deleterious mutations in two breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2 have been identified in breast and ovarian cancer families. Women with a BRCA1 or BRCA2 mutation are candidates for additional risk reduction measures such as intensive screening, prophylactic surgery or chemoprevention. Addit...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-007-9038-0
更新日期:2007-09-01 00:00:00
abstract::In the last 10 years, several studies have shown that the pancreas of patients with type 1 diabetes (T1D), and even of subjects at risk for T1D, was smaller than the pancreas from healthy subjects. This arose the question of the relationships between the endocrine and exocrine parts of the pancreas in T1D pathogenesis...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-019-09501-3
更新日期:2019-06-01 00:00:00
abstract::Obstructive sleep apnea (OSA) is a common disorder associated with cardiovascular disease (CVD). One theory to explain this relationship proposes that OSA can induce systemic inflammation, thereby inducing CVD. This theory is based on the premise that obesity is a pro-inflammatory state, and that physiological derange...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-014-9304-x
更新日期:2015-03-01 00:00:00
abstract::The response to retention hypothesis outlines the initial stages of atherosclerotic lesion formation. The central theme of the hypothesis is that proteoglycan mediated lipoprotein retention plays a critical step in the initiation of atherosclerosis development. Recent research using human arterial specimens, transgeni...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-008-9078-0
更新日期:2008-12-01 00:00:00
abstract::Adiponectin is among the most studied adipokines, the collection of molecules secreted from adipose tissue. It is also one of the most architecturally complex adipokines with its various oligomeric states that include trimers, hexamers, nonamers (9mers), dodecamers (12mers), and octadecamers (18mers). The importance o...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-013-9256-6
更新日期:2014-06-01 00:00:00
abstract::A clustering of metabolic abnormalities such as dyslipidemia, hypertension, and diabetes mellitus, all of which are major risk factors for cardiovascular disease (CVD), occurs more often than by chance. Numerous epidemiological studies, as well as basic researches, have revealed that visceral fat accumulation is close...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-014-9294-8
更新日期:2014-12-01 00:00:00
abstract::Myo-inositol (Myo-Ins) plays an important role in thyroid function and autoimmunity. Myo-Ins is the precursor for the synthesis of phosphoinositides, which takes part in the phosphatidylinositol (PtdIns) signal transduction pathway, and plays a decisive role in several cellular processes. In the thyroid cells, PtdIns ...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-018-9477-9
更新日期:2018-12-01 00:00:00
abstract::Vitamin D deficiency is highly prevalent among children and adolescents worldwide. The high rates of vitamin D deficiency during childhood are of major public health relevance, given the growing evidence that vitamin D deficiency may play a key role in the pathophysiology of many chronic diseases beyond rickets, inclu...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-007-9072-y
更新日期:2008-06-01 00:00:00
abstract::Glucokinase is a key enzyme involved in regulating insulin secretion from the pancreatic ß-cell. The unique role of glucokinase in human glucose physiology is illustrated by the fact that genetic mutations in glucokinase can either cause hyperglycaemia or hypoglycaemia. Heterozygous inactivating mutations in glucokina...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-010-9147-z
更新日期:2010-09-01 00:00:00
abstract::The 13th Acromegaly Consensus Conference was held in November 2019 in Fort Lauderdale, Florida, and comprised acromegaly experts including endocrinologists and neurosurgeons who considered optimal approaches for multidisciplinary acromegaly management. Focused discussions reviewed techniques, results, and side effects...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-020-09588-z
更新日期:2020-12-01 00:00:00
abstract::Vitamin D is a key hormone involved in the regulation of calcium/phosphorous balance and recently it has been implicated in the pathogenesis of sub-inflammation, insulin resistance and obesity. The two main forms of vitamin D are cholecalciferol (Vitamin D3) and ergocalciferol (Vitamin D2): the active form (1,25-dihyd...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-017-9423-2
更新日期:2017-06-01 00:00:00
abstract:UNLABELLED:We aimed to review and summarize the evidence from accomplished trials analyzing factors influencing mortality in patients with T2DM and to provide some recommendations for targets and treatment in the European region. The following databases were searched for relevant trials: PubMed and the Cochrane Library...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-016-9349-0
更新日期:2016-03-01 00:00:00
abstract::The carcinoid as originally described is part of the relatively large family of neuroendocrine neoplasia found in almost every organ. Historical reasons back their current definitions. Neuroendocrine cancer is most frequently observed in the lung and the digestive tract. In the lung is defined as carcinoid (typical an...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-017-9428-x
更新日期:2017-12-01 00:00:00
abstract::The ATP-sensitive potassium (K(ATP)) channel is composed of two subunits SUR1 and Kir6.2. The channel is key for glucose stimulated insulin release from the pancreatic beta cell. Activating mutations have been identified in the genes encoding these subunits, ABCC8 and KCNJ11, and account for approximately 40% of perma...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-010-9149-x
更新日期:2010-09-01 00:00:00
abstract::The last decade has been characterized by an intense research on the composition of the gut microbiome and the links with human health. While previous work was focused on the effects of prebiotics and probiotics, nowadays several laboratories are describing the gut microbiome and its metabolic functions. Gut microbiom...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-019-09533-9
更新日期:2019-12-01 00:00:00
abstract::Despite their critical role in susceptibility to metabolic diseases such as obesity and type 2 diabetes, mechanisms regulating energy balance are extremely complex and far from being fully understood. Both central and peripheral feedback circuits are involved and, despite it was traditionally thought that the energy b...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-020-09565-6
更新日期:2020-09-01 00:00:00
abstract::Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-012-9215-7
更新日期:2012-06-01 00:00:00
abstract::An increasingly pervasive environment of reduced activity and easy access to high caloric food is leading to an epidemic of poor cardiovascular fitness, obesity, insulin resistance and type 2 diabetes (T2DM) in children. Studies have shown that insulin resistance (IR) to be an independent predictor for morbidity as we...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-009-9109-5
更新日期:2009-09-01 00:00:00
abstract::The skeletal muscle is one of the major target organs of insulin and plays an essential role in insulin-induced glucose uptake. Some evidence indicates that insulin delivery to skeletal muscle interstitium through the endothelial cells is the rate-limiting step in insulin-stimulated glucose uptake. Researchers have al...
journal_title:Reviews in endocrine & metabolic disorders
pub_type: 杂志文章,评审
doi:10.1007/s11154-013-9242-z
更新日期:2013-06-01 00:00:00