Abstract：
:Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders characterized by androgen excess, oligo-ovulation and polycystic ovaries. Although ovaries are the main source of increased androgens in the syndrome, between 20 and 30% of patients with PCOS have adrenal androgen (AA) excess, detectable primarily by elevated dehydroepiandrosterone sulfate (DHEAS) levels. Patients with PCOS demonstrate a generalized hypersecretion of adrenocortical products, basally and in response to ACTH stimulation. The mechanisms of these abnormalities are unclear although AA excess in PCOS is likely a complex trait, modulated by both intrinsic and acquired factors. To date, no specific genetic defects have been identified. The production of AAs in response to ACTH appears to be closely related to altered factors regulating glucose-mediated glucose disposal, increased peripheral metabolism of cortisol, and to a less extent to the effects of extra-adrenal androgens, insulin resistance, hyperinsulinemia or obesity. Finally, DHEAS levels and the response of AAs to ACTH are relatively constant over time and are closely correlated between PCOS patients and their siblings suggesting that this abnormality is an inherited trait in PCOS.
journal_name
Rev Endocr Metab Disordjournal_title
Reviews in endocrine & metabolic disordersauthors
Yildiz BO,Azziz Rdoi
10.1007/s11154-007-9054-0subject
Has Abstractpub_date
2007-12-01 00:00:00pages
331-42issue
4eissn
1389-9155issn
1573-2606journal_volume
8pub_type
杂志文章,评审abstract：:Vitamin D is a key hormone involved in the regulation of calcium/phosphorous balance and recently it has been implicated in the pathogenesis of sub-inflammation, insulin resistance and obesity. The two main forms of vitamin D are cholecalciferol (Vitamin D3) and ergocalciferol (Vitamin D2): the active form (1,25-dihyd...
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journal_title：Reviews in endocrine & metabolic disorders
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更新日期：2010-12-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
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更新日期：2017-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-014-9302-z
更新日期：2015-03-01 00:00:00
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更新日期：2016-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2016-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
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更新日期：2014-12-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
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更新日期：2012-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-06-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
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journal_title：Reviews in endocrine & metabolic disorders
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更新日期：2008-12-01 00:00:00
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更新日期：2019-09-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2013-12-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
doi：10.1007/s11154-010-9129-1
更新日期：2010-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2013-03-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
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journal_title：Reviews in endocrine & metabolic disorders
pub_type： 杂志文章,评审
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更新日期：2009-09-01 00:00:00
