Abstract:
:We identified a gene encoding a novel secreted protein in mice, humans, and zebrafish. As the protein of 222 amino acids is similar to Brorin, a secreted BMP antagonist, which is a member of the Chordin family, we named it Brorin-like. Recombinant Brorin-like protein weakly but significantly inhibited the activity of BMP in mouse preosteoblastic cells and promoted neurogenesis in mouse neural precursor cells. Brorin-like was predominantly expressed in the adult brain and embryonic neural tissues. The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development. Brorin-like potentially plays roles in neural development and functions.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Miwa H,Miyake A,Kouta Y,Shimada A,Yamashita Y,Nakayama Y,Yamauchi H,Konishi M,Itoh Ndoi
10.1016/j.febslet.2009.10.044subject
Has Abstractpub_date
2009-11-19 00:00:00pages
3643-8issue
22eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00828-Xjournal_volume
583pub_type
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