Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:Damiana (Turnera diffusa Willd. Ex Schult) has traditionally been used as an herbal aphrodisiac. AIM OF THE STUDY:The study was aimed to investigate the anti-aromatse activity and the estrogenic activity of the constituents isolated from Turnera diffusa. MATERIALS AND METHODS:The methanolic extract and 24 compounds isolated from the leaves of Turnera diffusa were evaluated for aromatase activity by using a tritiated-water release assay and for estrogenic activity by using yeast estrogen screen (YES) assay. RESULTS:The methanolic extract demonstrated a dose-dependent inhibitory activity of the aromatase enzyme with the IC(50) value of 63.1 microg/ml. Among the 24 tested compounds, pinocembrin and acacetin showed the most potent inhibition with IC(50) values of 10.8 and 18.7 microM, respectively. Estrogenic activity was also observed in the extract and three compounds including apigenin 7-glucoside, Z-echinacin and pinocembrin with EC(50) values of 10, 20 and 67 microuM, respectively. CONCLUSIONS:The extract of Turnera diffusa and two isolated compounds pinocembrin and acacetin could significantly suppress aromatase activity. Moreover, apigenin 7-glucoside, Z-echinacin and pinocembrin showed estrogenic activity.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Zhao J,Dasmahapatra AK,Khan SI,Khan IAdoi
10.1016/j.jep.2008.09.016subject
Has Abstractpub_date
2008-12-08 00:00:00pages
387-93issue
3eissn
0378-8741issn
1872-7573pii
S0378-8741(08)00500-Xjournal_volume
120pub_type
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