Abstract：
ETHNOPHARMACOLOGICAL RELEVANCE:Oryeongsan (ORS, Wulingsan), a formula composed of five herbal medicines, has long been used for the treatment of impairments of the regulation of body fluid homeostasis in China, Japan and Korea. AIM OF THE STUDY:The purpose of the present study was to test the effects of ORS on the renal function and the mechanisms involved in rats. MATERIALS AND METHODS:Experiments were performed in rats caged individually. Renal function and plasma levels of renin activity and aldosterone concentration were measured. RESULTS:Treatment of ORS resulted in increases in urinary volume, excretion of Na(+), K(+), and Cl(-), and glomerular filtration rate, and decreases in urinary osmolality and Na(+) balance. Further, ORS decreased plasma renin activity and aldosterone concentration. An increase in urinay excretion of Na(+) was a function of glomerular filtration rate, while the increase in the day-time period was related with the increase in the ratio of urinary Na(+)/K(+). CONCLUSION:Therefore, the present results suggest that ORS induces diuresis and natriuresis via inhibition of the renin-angiotensin-aldosterone system in rats.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Ahn YM,Cho KW,Kang DG,Lee HSdoi
10.1016/j.jep.2012.02.021subject
Has Abstractpub_date
2012-06-14 00:00:00pages
780-5issue
3eissn
0378-8741issn
1872-7573pii
S0378-8741(12)00102-Xjournal_volume
141pub_type
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