Abstract:
:The vasorelaxant effect of garlic (Alium sativum L.) has been suggested to be partially mediated through endothelium. The present study was designed to evaluate the role of various endothelium-mediated mechanisms in vasorelaxant response of garlic on isolated aortic rings of rats. In tissues precontracted with phenylephrine (PE) 10(-6)M, concentration-response curve for different concentrations of garlic (1, 5, 10, 20 and 50 microg/ml) was examined. In all the preparations garlic showed a concentration-dependent vasorelaxant response. There was a significant attenuation of vasorelaxation in tissues pretreated with K(+) channel blocker, glybenclamide (10(-6)M). Indomethacin (10(-5)M) enhanced the relaxant response of garlic. N(G)-Monomethyl-L-arginine (L-NMMA) 30 microM, a potent inhibitor of nitric oxide synthase, did not produce any significant effect on the response of garlic. However, cGMP blocker methylene blue (10(-5)M) showed a strong vasoconstriction and inhibited the vasorelaxant response of garlic. The results indicate that endothelium modulated vasorelaxation of garlic is partly mediated through EDHFs and cycloxygenase pathways. However, relaxing factor(s) other than NO, mediated through cGMP has a major role in the vasorelaxant response of garlic.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Ashraf MZ,Hussain ME,Fahim Mdoi
10.1016/j.jep.2003.06.001keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
5-9issue
1eissn
0378-8741issn
1872-7573pii
S0378874103003672journal_volume
90pub_type
杂志文章abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Postmenopausal osteoporosis is the most common bone disease worldwide. Information concerning the effects of herbal medicines on mesenchymal cell osteogenesis and senescence remains lacking. AIM OF THIS STUDY:This study was designed to investigate the effects of Du-Huo-Ji-Sheng-Tang (DHJ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2016.12.011
更新日期:2017-02-23 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Terminalia arjuna (Roxb. ex DC.) Wight & Arn. (T. arjuna) has been widely used in the traditional ayurvedic system of medicine as a cardioprotectant and for acute and chronic renal diseases supporting its ethnopharmacological use. AIM OF THE STUDY:The present study aimed at evaluating th...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2016.01.002
更新日期:2016-03-02 00:00:00
abstract:ETHNOPHARMCOLOGICAL RELEVANCE:Microbial biofilm formation, a quorum sensing (QS) regulated process, is one of the major causes of nosocomial and chronic infections, foodborne diseases, and associated deaths. Various approaches have been used to eradicate the menace of biofilm. Ethnomedicinal plants as potent antibiofil...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.113699
更新日期:2021-04-06 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Sarcopoterium spinosum is a Mediterranean plant, widely used by the Beduin traditional medicine. While its major use is for the treatment of diabetes, there are also documentations for its use as anti-inflammatory agent. This therapeutic potential of Sarcopoterium spinosum was not validat...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2019.112391
更新日期:2020-03-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Withania somnifera root extract (Ws)/Ashwagandha/Indian ginseng is a traditional herbal medicine, used over 4000 years in India, shown to have effect on neural growth and locomotor function. Although catecholamines and oxidative stress resulting in neurodegeneration and locomotor disorder...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2009.08.003
更新日期:2009-09-25 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:This paper provides significant ethnopharmacological information on plants used to treat cardiovascular diseases in Navarra, Spain. MATERIAL AND METHODS:Information was collected using semi-structured ethnobotanical interviews with 667 informants (mean age 72; 55.47% women, 44.53% men) i...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2014.09.047
更新日期:2014-11-18 00:00:00
abstract::A list of newly identified plants is presented to supplement Part I (Joly et al. (1987) Journal of Ethnopharmacology 20, 145-171). A comparative analysis is made between our work and two other recent inventories of plants used by the Guaymi Indians of Panama and Costa Rica. As in Part I, the results of a literature su...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(90)90029-s
更新日期:1990-02-01 00:00:00
abstract::The effect of the butanol extract of Zizyphus spina-christi (L.), Willd (Rhamnaceae) leaves and its major saponin glycoside, christinin-A, on the serum glucose and insulin levels was studied in non-diabetic control, type-I (insulin-dependent) and type-II (non-insulin-dependent) diabetic rats. Pretreatment either with ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.04.007
更新日期:2005-10-03 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Pinellia pedatisecta Schott extract (PE), a traditional Chinese medicine, has been used to reduce swelling, dry dampness and suppress cervical tumors. AIMS:To evaluate the roles of PE in the regulation of anti-tumor effects and the cellular immune response in the tumor microenvironment. ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2018.04.037
更新日期:2018-10-28 00:00:00
abstract:AIM OF THE STUDY:Scutellaria barbata is a traditional Chinese medicine for cancer treatments. Pheophorbide-a (Pa), one of the active components isolated from this herbal medicine has been proposed to be a potential natural photosensitizer for photodynamic therapy. The anti-tumor effect of pheophorbide-a based photodyna...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2010.06.007
更新日期:2010-08-19 00:00:00
abstract:AIM OF THE STUDY:Around the world, Tilia species have been used in traditional medicine for their properties as tranquilizer. Furthermore, Mexican species of Tilia have been grouped as Tilia americana var. mexicana, but their specific content in flavonoids is poorly described. In this study, inflorescences of Mexican T...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2009.09.044
更新日期:2010-01-08 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Biophytum umbraculum Welw. (Oxalidaceae) is a highly valued African medicinal plant used for treatment of cerebral malaria, a critical complication of falciparum malaria. AIM OF THE STUDY:To provide additional information about traditional use of B. umbraculum and to test plant extracts ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2016.05.058
更新日期:2016-08-22 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Human dermatophyte infections are one of the most common classes of infection globally, with an estimated 1.7 billion people contracting at least one infection annually. Southern African ethnic groups used multiple plants to treat dermatophytosis and to alleviate the symptoms, yet the ant...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2019.112539
更新日期:2020-04-06 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham (commonly termed P. mirifica, PM) growing in upland Thailand has a long history as a postmenopausal rejuvenant therapy for indigenants. Its amelioration of menopause symptoms in clinical trials was assessed. MATERIALS AND ME...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2018.01.028
更新日期:2018-04-24 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Picea mariana ((Miller) Britton, Sterns, and Poggenburg; Pinaceae) bark has been traditionally used by North American natives for treating topical inflammations. It has been also suggested to improve various inflammatory skin disorders like Psoriasis vulgaris. Extracts from this bark stor...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2013.10.034
更新日期:2014-01-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:In Africa, traditional medicine encompasses a diverse range of practices, including herbalism and spiritualism, where some diseases are believed to be "African" since they can only be traditionally treated. Indigenous knowledge on the management of "African" diseases using medicinal plant...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.113578
更新日期:2021-03-25 00:00:00
abstract:AIM OF THE STUDY:In recent years the use of medicinal plants has been growing worldwide and this is particularly true in Lebanon. In the present investigation we report the inhibitory activity against digestive enzymes related to diabetes and angiotensin converting enzyme (ACE) of extracts of nine plant species collect...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2008.06.003
更新日期:2008-09-02 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The blister beetle, also known as Mylabris cichorii, is not only widely used in clinical applications in Chinese anticancer medicine, but is also one of the main ingredients in a variety of traditional Chinese medicinal preparations with anticancer activity. However, the strong toxicity e...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2016.03.058
更新日期:2016-06-20 00:00:00
abstract::This study was designed to determine the anti-proliferative, apoptotic properties of a novel polysaccharide from the loach, Misgurnus anguillicaudatus (MAP), using a human promyelocytic leukemia line (HL-60) as a model system. HL-60 cells were cultured in the presence of MAP at various concentrations (50-800 mg/l) for...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.02.033
更新日期:2005-07-14 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The leaves of Hancornia speciosa Gomes are popularly used in Brazil to treat diabetes and hypertension. Cardiovascular diseases are the main cause of death worldwide and their incidences are increasing in Brazilian population. The present study aimed to investigate the hypotensive effect ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2011.06.031
更新日期:2011-09-01 00:00:00
abstract:UNLABELLED:ETHNO-PHARMACOLOGICAL RELEVANCE: Chinese herbal products (CHP) are commonly used for menopausal syndrome in traditional Chinese medicine (TCM). AIM OF THE STUDY:Because menopausal syndrome is a common issue among women worldwide, this study analyzed the prescription patterns and frequencies of CHP in reliev...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2011.07.053
更新日期:2011-10-11 00:00:00
abstract::The hypoglycemic activity of the flavonoids rich fraction of 70% alcohol extract of the Egyptian Morus alba root bark (MRBF-3) was evaluated after its oral administration to streptozotocin-induced diabetic rats. Diabetes was induced by injection of 60 mg kg(-1) i.p. The administration of MRBF-3 to streptozotocin (STZ)...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.03.013
更新日期:2005-09-14 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Mesembrine alkaloids are considered to be the primary active constituents of the South African medicinal plant Sceletium tortuosum (L.) N.E.Br. (Aizoaceae), and it is used as the dried or fermented aerial material from the plant, which is known as kanna (aka, channa, kougoed). Traditional...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2016.12.004
更新日期:2017-01-04 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Renal fibrosis (RF) is a common outcome of various progressive chronic kidney diseases (CKDs) and, thus, seriously endangers human health. As the active ingredient of Amygdalus mongolica, amygdalin inhibits RF. Furthermore, our previous studies demonstrated that n-butanol extract (BUT) an...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.112858
更新日期:2020-07-15 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Diabetes mellitus (DM) is one of the most prevalent diseases globally and is of considerable concern to global health. Approximately 425 million people are estimated to have DM globally and this is predicted to increase to >642 million by 2040. Whilst the prevalence of DM in South Africa ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.jep.2020.113234
更新日期:2021-01-10 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Cimicifuga foetida L., a traditional Chinese medicine, has been used as an anti-inflammatory, antipyretic and analgesic remedy. The primary active constituents are believed to be present in the triterpene glycoside fraction. MATERIALS AND METHODS:To develop an LC-MS/MS assay for four maj...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2012.06.031
更新日期:2012-08-30 00:00:00
abstract:AIM OF THE STUDY:Depression is a severe mood disorder. It was treated with Shudihuang, the steamed roots of Rehmannia glutinota Libosch. (SRG), in traditional Chinese medicine. The present paper was designed to verify its antidepressant effect. MATERIALS AND METHODS:A mouse model of depression was established though u...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2009.02.029
更新日期:2009-05-04 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ferox and Aloe marlothii are used as traditional medicines for different applications. Although wou...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2017.02.017
更新日期:2017-03-22 00:00:00
abstract::The aqueous extract obtained from Stichaster striatus Müller & Troschel (Asteroidea, Stichasteridae) has been shown to possess activity as an alcohol appetite inhibitor after oral administration in a rat model with a genetically established excessive appetite for alcohol (Wistar rats, lineage UChB). A significant decr...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.08.078
更新日期:2006-04-21 00:00:00
abstract::The stem barks of Pera benensis are employed by the Chimane Indians in the Bolivian Amazonia as treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. The chloroform extracts containing quinones were found active against the promastigote forms of Leishmania and the epimastigote forms of ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(92)90074-2
更新日期:1992-09-01 00:00:00