当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Antiplasmodial, anti-complement and anti-inflammatory in vitro effects of Biophytum umbraculum Welw. traditionally used against cerebral malaria in Mali.

Antiplasmodial, anti-complement and anti-inflammatory in vitro effects of Biophytum umbraculum Welw. traditionally used against cerebral malaria in Mali.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Biophytum umbraculum Welw. (Oxalidaceae) is a highly valued African medicinal plant used for treatment of cerebral malaria, a critical complication of falciparum malaria. AIM OF THE STUDY:To provide additional information about traditional use of B. umbraculum and to test plant extracts and isolated compounds for in vitro activities related to cerebral malaria. MATERIALS AND METHODS:The traditional practitioners were questioned about indication, mode of processing/application, dosage and local name of B. umbraculum. Organic extracts and some main constituents of the plant were investigated for anti-malaria, anti-complement activity and inhibition of NO secretion in a RAW 264.7 cell line. RESULTS:Treatment of cerebral malaria was the main use of B. umbraculum (fidelity level 56%). The ethyl acetate extract showed anti-complement activity (ICH50 5.7±1.6μg/ml), inhibition of macrophage activation (IC50 16.4±1.3μg/ml) and in vitro antiplasmodial activity (IC50 K1 5.6±0.13μg/ml, IC50 NF54 6.7±0.03μg/ml). The main constituents (flavone C-glycosides) did not contribute to the activity of the extract. CONCLUSION:Inhibition of complement activation and anti-inflammatory activity of B. umbraculum observed in this study might be possible targets for adjunctive therapy in cerebral malaria together with its antiplasmodial activity. However, clinical trials are necessary to evaluate the activity due to the complex pathogenesis of cerebral malaria.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Austarheim I,Pham AT,Nguyen C,Zou YF,Diallo D,Malterud KE,Wangensteen H

doi

10.1016/j.jep.2016.05.058

subject

Has Abstract

pub_date

2016-08-22 00:00:00

pages

159-64

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(16)30339-7

journal_volume

190

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Plants of the genus Mahonia Nuttall (Berberidaceae) have a long history of medical use in Traditional Chinese Medicine (TCM) for the treatment of a wide range of health disorders, such as tuberculosis, periodontitis, dysentery, pharyngolaryngitis, eczema, and wounds. In the theory of TCM,...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2015.09.013

    authors： He JM,Mu Q

    更新日期：2015-12-04 00:00:00

  • Cytotoxic ethnic Yao medicine Baizuan, leaves of Schisandra viridis A. C. Smith.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The ethnic Chinese Yao medicine Baizuan, which are the leaves of Schisandra viridis A. C. Smith, is traditionally used, in combination with other herbs, to soften hard lumps and dispel nodes in the treatment of cancer, however, this property has not been well studied with a clear indicati...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.09.016

    authors： Hou X,Deng J,Zhang Q,Wang D,Kennedy D,Quinn RJ,Feng Y

    更新日期：2016-12-24 00:00:00

  • Phoradendron liga (Gill. ex H. et A.) Eichl. (Viscaceae) used in folk medicine: anatomical, phytochemical, and immunochemical studies.

    abstract：:Phoradendron liga (Gill. ex H. et A.) Eichl. is a Viscaceae widely distributed in Argentina. It has been commonly used in folk medicine as a substitute of the European mistletoe (Viscum album L.) to decrease high blood pressure due to their external similarity. In this study, the anatomical features as well as micromo...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.04.027

    authors： Varela BG,Fernández T,Ricco RA,Zolezzi PC,Hajos SE,Gurni AA,Alvarez E,Wagner ML

    更新日期：2004-09-01 00:00:00

  • Nitrites and nitrates in the human diet: Carcinogens or beneficial hypotensive agents?

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The presence of nitrite in the human diet was thought to constitute a hazard as secondary nitrosamines are known to cause gastric cancers. MATERIALS AND METHODS:Recent publications on the physiology of serum nitrite have been consulted. PROBLEMS:Nitrite is added to some foodstuffs as an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.09.040

    authors： Butler A

    更新日期：2015-06-05 00:00:00

  • Anti-inflammatory activity of Lychnophora passerina, Asteraceae (Brazilian "Arnica").

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Lychnophora passerina (Asteraceae), popularly known as "arnica," is used to treat inflammation, pain, rheumatism, contusions, bruises and insect bites in Brazilian traditional medicine. MATERIALS AND METHODS:The anti-inflammatory activity of crude ethanolic extract of aerial parts of L. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.03.034

    authors： Capelari-Oliveira P,Paula CA,Rezende SA,Campos FT,Grabe-Guimarães A,Lombardi JA,Saúde-Guimarães DA

    更新日期：2011-05-17 00:00:00

  • Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The rhizomes of Kaempferia parviflora Wall. ex Baker have been traditionally used in Thailand to treat abscesses, gout, and peptic ulcers. AIM:Previously, we reported that the chloroform fraction of a Kaempferia parviflora extract had an inhibitory effect on rat paw-edema. In the present...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.01.013

    authors： Sae-Wong C,Matsuda H,Tewtrakul S,Tansakul P,Nakamura S,Nomura Y,Yoshikawa M

    更新日期：2011-07-14 00:00:00

  • A semi-quantitative approach to the selection of appropriate candidate plant molluscicides--a South African application.

    abstract：:The high cost of synthetic molluscicides, used in the control of the intermediate snail hosts of schistosomiasis (bilharzia), has resulted in renewed interest in plant molluscicides. The history of the use of plant molluscicides is reviewed. Although screening programmes have been conducted in other African countries,...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(96)01495-x

    authors： Clark TE,Appleton CC,Drewes SE

    更新日期：1997-03-01 00:00:00

  • Wound healing activity of Calotropis gigantea root bark in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Calotropis gigantea R.Br. (Asclepiadaceae) is a perennial undershrub found chiefly in wastelands throughout India. It has been reported as a traditional folkloric medicine for a variety of alignments. The plant Calotropis gigantea is also used in some parts of India for wound healing in c...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.06.007

    authors： Deshmukh PT,Fernandes J,Atul A,Toppo E

    更新日期：2009-08-17 00:00:00

  • Petroleum ether extractive of the hips of Rosa multiflora ameliorates collagen-induced arthritis in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The hip of Rosa multiflora Thunb. (HRM) has been traditionally used as a dietary supplement and a herbal remedy for the treatment of various diseases, including inflammation, osteoarthritis, rheumatoid arthritis and chronic pain, in China. The current study was to evaluate the therapeutic...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.09.026

    authors： Wu J,Liu X,Chan CO,Mok DK,Chan SW,Yu Z,Chen S

    更新日期：2014-11-18 00:00:00

  • The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Fufang Chuanxiong capsule consists of Angelica sinensis radix and Chuanxiong rhizome, which are used in the traditional Chinese medicine for the treatment of coronary artery disease, and Xinyue capsule is composed of panax quinquefolius saponin extracted from leaves and stems of Panax qui...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jep.2019.112354

    authors： Zhang DW,Wang SL,Wang PL,Du JP,Gao ZY,Wang CL,Xu H,Shi DZ

    更新日期：2020-02-10 00:00:00

  • Anti-inflammatory effects of ethanolic extract and alkamides-derived from Heliopsis longipes roots.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Heliopsis longipes (A. Gray) Blake (Asteraceae) is a broadly used species in the Mexican, Central and South American Traditional Medicine for its anaesthetic, analgesic, anti-inflammatory and anti-ulcerative properties. The ethanolic extract contains alkamides, mainly affinin (spilanthol)...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.04.060

    authors： Hernández I,Márquez L,Martínez I,Dieguez R,Delporte C,Prieto S,Molina-Torres J,Garrido G

    更新日期：2009-07-30 00:00:00

  • Laboratory evaluation of the acaricidal properties of extracts from Uraria picta (Leguminosae).

    abstract：:Ethomedical uses of the plant, Uraria picta (Leguminosae), in Nigeria include the control of ectoparasites in man and domestic animals. Total and fractionated extracts of this plant have been assessed for acaricidal activity on Ixodes ricinus. All the extracts were acaricidal to the test organisms. Methanolic extract ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(89)90102-5

    authors： Igboechi AC,Osazuwa EO,Igwe UE

    更新日期：1989-10-01 00:00:00

  • Effect of Vaccinium bracteatum Thunb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice.

    abstract：AIM OF THE STUDY:To investigate the hypoglycemic effects of Vaccinium bracteatum Thunb. leaves (VBTL) extract in streptozotocin-induced diabetic mice. MATERIALS AND METHODS:After administration of VBTL extract for 4 weeks, the body weight, organ weight, blood glucose (BG), insulin and plasma lipid levels of streptozot...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.05.031

    authors： Wang L,Zhang XT,Zhang HY,Yao HY,Zhang H

    更新日期：2010-08-09 00:00:00

  • Melissa officinalis L. - A review of its traditional uses, phytochemistry and pharmacology.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Melissa officinalis L. is a medicinal plant that has long been used in different ethno-medical systems especially in the European Traditional Medicine and the Iranian Traditional Medicine for the treatment of several diseases. It is also widely used as a vegetable and to add flavor to dis...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2016.05.010

    authors： Shakeri A,Sahebkar A,Javadi B

    更新日期：2016-07-21 00:00:00

  • Intestinal anti-inflammatory effects of fuzi-ganjiang herb pair against DSS-induced ulcerative colitis in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Fuzi and ganjiang are widely used as traditional Chinese medicines (TCM) in China, Korea, Japan, and many other southeast Asian countries for treating ulcerative colitis (UC), emesis and heart failure for more than 1800 years. However, the underlying mechanism of fuzi, ganjiang and fuzi-g...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112951

    authors： Huang C,Dong J,Jin X,Ma H,Zhang D,Wang F,Cheng L,Feng Y,Xiong X,Jiang J,Hu L,Lei M,Wu B,Zhang G

    更新日期：2020-10-28 00:00:00

  • Inhalation of Cedrus atlantica essential oil alleviates pain behavior through activation of descending pain modulation pathways in a mouse model of postoperative pain.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cedrus atlantica essential oil (CaEO) presents analgesic and anti-inflammatory sedative properties. However, it remains unknown whether CaEO alleviates acute postoperative pain. MATERIALS AND METHODS:Here, we investigated the effect of CaEO on postoperative pain and its mechanisms relate...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.08.048

    authors： Martins DF,Emer AA,Batisti AP,Donatello N,Carlesso MG,Mazzardo-Martins L,Venzke D,Micke GA,Pizzolatti MG,Piovezan AP,dos Santos AR

    更新日期：2015-12-04 00:00:00

  • Evidence of anti-inflammatory and antinociceptive activities of Plinia edulis leaf infusion.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Plinia edulis (Vell.) Sobral (Myrtaceae) is native and endemic to the Brazilian Atlantic Rainforest. Popularly known as "cambucá", it has been used in folk medicine for the treatment of stomach disorders, diabetes, bronchitis, inflammation and as tonic. Although there are numerous records...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.07.001

    authors： Azevedo LF,Silva SMD,Navarro LB,Yamaguchi LF,Nascimento CGO,Soncini R,Ishikawa T

    更新日期：2016-11-04 00:00:00

  • Medicinal mosses in pre-Linnaean bryophyte floras of central Europe. An example from the natural history of Poland.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The paper presents information about the earliest botanical work from Poland, Warsavia physice illustrata which takes bryophytes into account. It was elaborated by a German physician Christian Heinrich Erndtel and issued in 1730 in Dresden. That time understanding of bryophytes was imprec...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.jep.2014.03.025

    authors： Drobnik J,Stebel A

    更新日期：2014-05-14 00:00:00

  • Anticancer potential of aqueous extract of alocasia macrorrhiza against hepatic cancer in vitro and in vivo.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Alocasia macrorrhiza has been used as a folk medicine for cancer treatment in the Southwest of China. AIM OF THE STUDY:The purpose of this study is to confirm the anticancer activity of aqueous extract of alocasia macrorrhiza against hepatic cancer and to elucidate its mechanism of actio...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.03.037

    authors： Fang S,Lin C,Zhang Q,Wang L,Lin P,Zhang J,Wang X

    更新日期：2012-06-14 00:00:00

  • Protective effects of Glycyrrhiza glabra supplementation against methotrexate-induced hepato-renal damage in rats: An experimental approach.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In traditional medicine, Glycyrrhiza glabra, commonly known as liquorice, is known to possess promising pharmacological properties including anti-oxidative, anti-inflammatory, gastro, hepato and nephro-protective activities. AIM:The present study investigated the protective effects of Gl...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113209

    authors： Chauhan P,Sharma H,Kumar U,Mayachari A,Sangli G,Singh S

    更新日期：2020-12-05 00:00:00

  • Essential oil from Fructus Alpinia zerumbet (fruit of Alpinia zerumbet (Pers.) Burtt.et Smith) protected against aortic endothelial cell injury and inflammation in vitro and in vivo.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Fructus Alpinia zerumbet (FAZ), a dry and ripe fruit of Alpinia zerumbet (Pers.) Burtt. et Smith, is widely used as a spice to treat cardiovascular diseases in clinic as a miao folk medicine in Guizhou Province of China. Essential oil extracted from FAZ (EOFAZ) is the key bioactive ingred...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.03.011

    authors： Ji YP,Shi TY,Zhang YY,Lin D,Linghu KG,Xu YN,Tao L,Lu Q,Shen XC

    更新日期：2019-06-12 00:00:00

  • Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:G. pentaphyllum, also known as Jiao-Gu-Lan, has been used traditionally as folk remedies for many diseases, including diabetes mellitus, metabolic syndrome, aging, and neurodegenerative diseases in China and some countries in East and Southeast Asia. It is considered as an "immortality he...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113574

    authors： Nguyen NH,Ha TKQ,Yang JL,Pham HTT,Oh WK

    更新日期：2021-03-25 00:00:00

  • Plumeria rubra L.- A review on its ethnopharmacological, morphological, phytochemical, pharmacological and toxicological studies.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Plumeria rubra L. (Apocynaceae) is a deciduous, commonly ornamental, tropical plant grown in home premises, parks, gardens, graveyards, because of its beautiful and attractive flowers of various colours and size. The different parts of the plant are used traditionally to treat various dis...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113291

    authors： Bihani T

    更新日期：2021-01-10 00:00:00

  • Chemical characterization and evaluation of gastric antiulcer properties of the hydroethanolic extract of the stem bark of Virola elongata (Benth.) Warb.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Virola elongata is a tree species belonging to the Myristicaceae family, distributed in the North and Midwest regions of Brazil, in the phytogeographic domain of the Amazon. The aqueous infusion or the hydroethanolic macerate of the stem bark of V. elongata are used in Brazilian and Ecuad...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2018.11.011

    authors： Almeida GVB,Arunachalam K,Balogun SO,Pavan E,Ascêncio SD,Soares IM,Zanatta AC,Vilegas W,Macho A,Oliveira Martins DT

    更新日期：2019-03-01 00:00:00

  • Antimutagenicity and induction of antioxidant defense by flavonoid rich extract of Myrcia bella Cambess. in normal and tumor gastric cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The Brazilian "Cerrado" is an important source of natural products, such as Myrcia bella Cambess (MB, also known as "mercurinho"). MB leaves are popularly used for the treatment of diabetes and gastrointestinal disorders; however, only its hypoglycemic activity has been experimentally des...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.11.003

    authors： Serpeloni JM,Specian AF,Ribeiro DL,Tuttis K,Vilegas W,Martínez-López W,Dokkedal AL,Saldanha LL,Cólus IM,Varanda EA

    更新日期：2015-12-24 00:00:00

  • Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway.

    abstract：AIM OF THE STUDY:To investigate the effect of tashinone IIA (TA) on intimal hyperplasia in a rat model of carotid artery balloon injury and on the proliferation of cultured vascular smooth muscle cells (VSMCs) induced by fetal bovine serum (FBS) and its underlying mechanisms. MATERIALS AND METHODS:Carotid artery injur...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.03.021

    authors： Li X,Du JR,Yu Y,Bai B,Zheng XY

    更新日期：2010-05-27 00:00:00

  • Antiarthritic activity of various extracts of Mesua ferrea Linn. seed.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Mesua ferrea Linn. (Cluciaseae), Cobra's saffron, is named after the heaviness of its timber and is cultivated in tropical climates for its form, foliage, and fragrant flowers. It is prescribed in the Ayurvedic literature for the treatment of pain, inflammation, and rheumatic conditions. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.09.042

    authors： Jalalpure SS,Mandavkar YD,Khalure PR,Shinde GS,Shelar PA,Shah AS

    更新日期：2011-12-08 00:00:00

  • Bakera, a herbal steam bath for postnatal care in Minahasa (Indonesia): documentation of the plants used and assessment of the method.

    abstract：:Bakera, a steam bath prepared with various plants, is a traditional method used in Minahasa (North Sulawesi, Indonesia) for recuperation after childbirth. Semi-structured interviews were conducted with 14 midwives and 166 mothers in different villages of Minahasa, in order to document the preparation and plants used f...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.01.016

    authors： Zumsteg IS,Weckerle CS

    更新日期：2007-05-22 00:00:00

  • Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats.

    abstract：:The lipid lowering activity (LLA) of Phyllanthus niruri has been studied in triton and cholesterol fed hyperlipemic rats. Serum lipids were lowered by P. niruri extract orally fed (250 mg/kg b.w.) to the triton WR-1339 induced hyperlipemic rats. Chronic feeding of this drugs (100 mg/kg b.w.) in animals simultaneously ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00136-8

    authors： Khanna AK,Rizvi F,Chander R

    更新日期：2002-09-01 00:00:00

  • Antidiabetic and antihyperlipidaemic effect of alcoholic Syzigium cumini seeds in alloxan induced diabetic albino rats.

    abstract：:Syzigium cumini, commonly known as 'jamun', is widely used in different parts of India for the treatment of diabetes mellitus. The present study was designed to evaluate the antidiabetic and antihyperlipidaemic effect of an alcoholic extract of Syzigium cumini seeds (JSEt) in alloxan diabetic rats. Diabetes was induce...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2003.11.001

    authors： Prince PS,Kamalakkannan N,Menon VP

    更新日期：2004-04-01 00:00:00