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A review of the traditional use of southern African medicinal plants for the treatment of fungal skin infections.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Human dermatophyte infections are one of the most common classes of infection globally, with an estimated 1.7 billion people contracting at least one infection annually. Southern African ethnic groups used multiple plants to treat dermatophytosis and to alleviate the symptoms, yet the anti-dermatophyte properties of most species remain poorly explored. AIM OF THE STUDY:Our study aimed to critically review the literature to document southern African plant species used to treat one or more dermatophytic infections, and to summarise scientific evaluations of these and other plant species. Our study aims to stimulate and focus future studies in this field. MATERIALS AND METHODS:A thorough review of the ethnobotanical books, reviews and primary scientific studies were undertaken to identify southern African plants used traditionally to treat dermatophytosis, thereby identifying gaps in the research requiring further study. RESULTS:Eighty-nine southern African plant species are recorded as traditional therapies for dermatophytosis. Scientific evaluations of 140 plant species were identified, although most of the species in those studies were selected for reasons apart from their traditional uses. None of those studies examined the mechanism of action of the plant species, and only a single study screened the extracts for toxicity. CONCLUSIONS:Despite southern Africa having some of the longest continuous human civilisations globally, as well as unique and diverse flora, and good ethnobotanical records, the anti-dermatophyte properties of southern African medicinal plants remains relatively poorly explored. The efficacy of the majority of plants used traditionally to treat fungal skin disease are yet to be verified and substantial further research is required in this field.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Cock IE,Van Vuuren SF

doi

10.1016/j.jep.2019.112539

subject

Has Abstract

pub_date

2020-04-06 00:00:00

pages

112539

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(19)34655-0

journal_volume

251

pub_type

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A review of the traditional use of southern African medicinal plants for the treatment of fungal skin infections.