Recovery of the hematopoietic system by Si-Jun-Zi-Tang in whole body irradiated mice.

Abstract:

:The herbal formulation Si-Jun-Zi-Tang reduced the decrease of leukocytes, erythrocytes, thrombocytes and hematocrit in irradiated mice. In general, its protection was more effective in leukocytes and thrombocytes than other hematocytes. Protection of bone marrow stem cells by Si-Jun-Zi-Tang was markedly enhanced by increased radiotolerance under the dose ranging from 0 to 5 Gy. This increased radiotolerance led to a prolonged shoulder in the survival curve but did not influence the D0 value. Si-Jun-Zi-Tang exerted a beneficial effect on clinical syndromes such as anemia. From the results in this study, we concluded preliminarily that the most effective concentration with least toxicity was about 20 mg/20 g body weight. At this dose, levels of leukocytes as well as thrombocytes were enhanced significantly after chi-irradiation. Elevation of erythrocytes and hematocrits could also be found but was not significant.

journal_name

J Ethnopharmacol

authors

Hsu HY,Yang JJ,Lian SL,Ho YH,Lin CC

doi

10.1016/s0378-8741(96)01450-x

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

69-75

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(96)01450-X

journal_volume

54

pub_type

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