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Pharmacological evaluation of sedative-hypnotic activity and gastro-intestinal toxicity of Rhizoma Paridis saponins.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Rhizoma Paridis saponins (RPS) have been well studied for antimicrobial, anti-hemorrhagic, and anticancer effects. However, scientific information on RPS regarding the toxic and neuropharmacological effects is limited. In this study, the acute oral toxicity, sedative-hypnotic activity and gastro-intestinal toxicity of RPS were investigated. MATERIALS AND METHODS:The acute toxicity was carried out by administering single doses (800-5000 mg/kg) of RPS to adult mice. Rotarod test and sodium pentobarbital-induced hypnosis activity were used to evaluate the neuropharmacological effects on mice. Gastric emptying and intestinal transit were used to investigate the gastric-intestinal system effects. RESULTS:A single oral administration of RPS dose-dependently caused adverse effects on the general behavior and mortality rate of mice. LD(50) value of oral acute toxicity was 2182.4 mg/kg, with 95% confidence limit of 1718.4-2807.8 mg/kg. In the test of sleeping mice, RPS acted in synergy with sodium pentobarbital at doses 250 and 500 mg/kg while motor coordination was not influenced within 120 min after treatment with RPS. Regarding the gastric-intestinal toxicity, RPS (100, 250, and 500 mg/kg) significantly inhibited gastric emptying but did not affect the intestinal transit. CONCLUSIONS:RPS, which is a hypotoxic anticancer drug, possesses the sedative-hypnotic activity and gastric stimulus side effect.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Liu Z,Gao W,Man S,Wang J,Li N,Yin S,Wu S,Liu C

doi

10.1016/j.jep.2012.08.027

subject

Has Abstract

pub_date

2012-10-31 00:00:00

pages

67-72

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(12)00552-1

journal_volume

144

pub_type

杂志文章

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