当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Modulation effect of Smilax glabra flavonoids on ryanodine receptor mediated intracellular Ca2+ release in cardiomyoblast cells.

Modulation effect of Smilax glabra flavonoids on ryanodine receptor mediated intracellular Ca2+ release in cardiomyoblast cells.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Smilax glabra rhizome, a plant material from Liliaceae family, is a widely used traditional Chinese medicine for anti-cardiac hypertrophy treatment. We have previously found that Smilax glabra flavonoids (SGF) exerted such anti-cardiac hypertrophy activity. However, the mechanism of this activity of SGF has not been clarified yet. MATERIALS AND METHODS:This study was aimed to investigate the inhibitory role of SGF on intracellular Ca(2+) release in rat cardiomyoblast cells (H9C2). Intracellular Ca(2+) release was determined by Ca(2+) indicator fluorescence (fluo 4-AM) in H9C2 cell line. RESULTS:SGF at concentrations of 0.25, 0.5, 1.0mg/ml significantly inhibited the phenylephrine or angiotensin II induced intracellular Ca(2+) release in a dose-dependent manner. Furthermore, SGF could also inhibit ryanodine receptor (RyR) agonist caffeine induced Ca(2+) release and phenylephrine (PE)-induced Ca(2+) release under the condition in which inositol trisphosphate (IP3) receptors were blocked with 2-Aminoethoxydiphenyl borate (2-APB). Nevertheless, SGF had no impact on PE-induced Ca(2+) release under the condition in which RyRs were blocked with tetracaine. CONCLUSIONS:Our results suggest that the protective effects of SGF are mediated via targeting inhibition of RyR mediated intracellular Ca(2+) release.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Shou Q,Pan S,Tu J,Jiang J,Ling Y,Cai Y,Chen M,Wang D

doi

10.1016/j.jep.2013.08.009

subject

Has Abstract

pub_date

2013-10-28 00:00:00

pages

389-92

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(13)00551-5

journal_volume

150

pub_type

杂志文章

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