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Effect of a herbal protein, CI-1, isolated from Cajanus indicus on immune response of control and stressed mice.

Abstract：

:The effect of a herbal protein, CI-1, purified from the leaves of Cajanus indicus was evaluated as a probable immunomodulator on immune response in control and stressed mice. In mice, sensitized with sheep red blood cells (SRBC), CI-1 enhanced IgG level by 28% over control (P < 0.05). Primary and secondary antibody response to SRBC and bovine serum albumin (BSA) were significantly increased in CI-1 treated group. Furthermore CI-1 facilitated the delayed type of hypersensitivity (DTH) response to SRBC in sensitized mice and also enhanced leucocyte and macrophage migration inhibition response in immunized mice. A fewer mice displayed symptoms of anaphylactic shock after CI-1 administration at a dose of 6.0 mg/kg body wt. in BSA sensitized mice. The immediate effect of CI-1 on anaphylactic shock was not seen when 150 microg of CI-1 was injected in combination with BSA in the shocking injection. These results suggest that CI-1 influences both humoral and cell-mediated immune response.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Datta S,Sinha S,Bhattacharyya P

doi

10.1016/s0378-8741(99)00046-x

keywords:

subject

Has Abstract

pub_date

1999-11-30 00:00:00

pages

259-67

issue

3

eissn

0378-8741

issn

1872-7573

pii

S037887419900046X

journal_volume

67

pub_type

杂志文章

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