Biological and analytical characterization of two extracts from Valeriana officinalis.

Abstract:

:The anticoronaryspastic and antibronchospastic activities of ethanolic and aqueous extracts of Valeriana officinalis L. roots were investigated in anaesthetized guinea-pigs and the results were correlated with the qualitative/quantitative chemical composition of the extracts in order to account for some of the common uses of this plant. The protective effects of orally administered ethanolic and aqueous extracts (50, 100 and 200 mg/kg) were evaluated against pitressin-induced coronary spasm and pressor response in guinea-pigs and were compared with those of nifedipine. Furthermore, the protective effects against histamine-induced and Oleaceae antigen challenge-induced bronchospasm were evaluated. Finally, the two valerian extracts were analytically characterized by qualitative and quantitative chromatographic analysis. The results showed that the two valeriana extracts possessed significant anticoronaryspastic, antihypertensive and antibronchospastic properties. These were similar to those exhibited by nifedipine and are due to the structural features of the active principles they contain. This study justifies the traditional use of this plant in the treatment of some respiratory and cardiovascular disorders.

journal_name

J Ethnopharmacol

authors

Circosta C,De Pasquale R,Samperi S,Pino A,Occhiuto F

doi

10.1016/j.jep.2007.03.021

subject

Has Abstract

pub_date

2007-06-13 00:00:00

pages

361-7

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00152-3

journal_volume

112

pub_type

杂志文章