Abstract:
:The anticoronaryspastic and antibronchospastic activities of ethanolic and aqueous extracts of Valeriana officinalis L. roots were investigated in anaesthetized guinea-pigs and the results were correlated with the qualitative/quantitative chemical composition of the extracts in order to account for some of the common uses of this plant. The protective effects of orally administered ethanolic and aqueous extracts (50, 100 and 200 mg/kg) were evaluated against pitressin-induced coronary spasm and pressor response in guinea-pigs and were compared with those of nifedipine. Furthermore, the protective effects against histamine-induced and Oleaceae antigen challenge-induced bronchospasm were evaluated. Finally, the two valerian extracts were analytically characterized by qualitative and quantitative chromatographic analysis. The results showed that the two valeriana extracts possessed significant anticoronaryspastic, antihypertensive and antibronchospastic properties. These were similar to those exhibited by nifedipine and are due to the structural features of the active principles they contain. This study justifies the traditional use of this plant in the treatment of some respiratory and cardiovascular disorders.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Circosta C,De Pasquale R,Samperi S,Pino A,Occhiuto Fdoi
10.1016/j.jep.2007.03.021subject
Has Abstractpub_date
2007-06-13 00:00:00pages
361-7issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(07)00152-3journal_volume
112pub_type
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of ethnopharmacology
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pub_type: 杂志文章
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更新日期:2016-12-24 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2005-08-22 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2016-12-04 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 历史文章,杂志文章
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更新日期:2006-12-06 00:00:00
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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更新日期:2020-12-05 00:00:00
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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更新日期:2014-05-28 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2008-06-19 00:00:00
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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