当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Anxiolytic effect of an extract of Salvia miltiorrhiza Bunge (Danshen) in mice.

Anxiolytic effect of an extract of Salvia miltiorrhiza Bunge (Danshen) in mice.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Salvia miltiorrhiza Bunge (Danshen), a traditional Chinese medicine, has demonstrated in modern studies for its pharmacological activities in treatments of CNS disorders like insomnia, dysphoria. However, its application on anxiolytic effect from the ethanol extract of Salvia miltiorrhiza Bunge (SMEtOH) has not yet been reported. MATERIALS AND METHODS:This study investigated the anxiolytic effect of the SMEtOH using the elevated plus-maze test (EPM) and the hole-board test (HBT) with diazepam and buspirone as positive controls. Also, the spontaneous locomotor activity of mice had been investigated in the open field. Further, we have illustrated the anxiolytic mechanisms of SMEtOH with its influencing upon GABAergic and/or serotonergic nervous systems via a method that SMEtOH was co-administered with flumazenil, a benzodiazepine (BZD) antagonist, or a drug (WAY-100635), a selective 5HT1A receptor antagonist. RESULTS:In hole-board test, results presented that SMEtOH increased head-dip counts and duration time. On the other hand, a decrease in spontaneous locomotor activity was observed. In the EPM test, SMEtOH increased the percentage of open-arm entries and the percentage of time spent in open arms. However, when SMEtOH co-administered with flumazenil or WAY-100635, the anxiolytic effect of SMEtOH was significantly counteracted. CONCLUSION:From these results, we can conclude that the anxiolytic mechanism of SMEtOH is exerted through an activation of the BZD and 5HT1A receptors.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Lin YS,Peng WH,Shih MF,Cherng JY

doi

10.1016/j.jep.2020.113285

subject

Has Abstract

pub_date

2021-01-10 00:00:00

pages

113285

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(20)33167-6

journal_volume

264

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Evaluation of anti-amnesic effect of extracts of selected Ocimum species using in-vitro and in-vivo models.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ocimum species are traditionally used for the treatment of anxiety, nerve pain, convulsions and a variety of neurodegenerative disorders. The present study was undertaken to evaluate the anti-amnesic effect of O. basilicum L., O. sanctum L. and O. gratissimum L. extracts using in-vitro an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.10.026

    authors： Singh V,Kahol A,Singh IP,Saraf I,Shri R

    更新日期：2016-12-04 00:00:00

  • Effect of essential oil of Syringa pinnatifolia Hemsl. var. alashanensis on ischemia of myocardium, hypoxia and platelet aggregation.

    abstract：AIM OF THE STUDY:To investigate the cardioprotective potential of Syringa pinnatifolia Hems1. var. alashanensis essential oil (SPEO) against experimental acute myocardial ischemia (AMI), hydrogen peroxide (H(2)O(2))-induced myocyte injury and activities against hypoxia and platelet aggregation. MATERIALS AND METHODS:W...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.06.027

    authors： Yan Y,O W,Zhao X,Ye X,Zhang C,Hao J,He J,Zhu X,Xu H,Yang X

    更新日期：2010-09-15 00:00:00

  • Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4/IKK/NF-κB signal pathway.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:TMHM is a type of Chinese medicine commonly used in medical practice and has multiple functions, including clearing heat, detoxification, reducing swelling, and tumor therapy. Previous research has demonstrated that the OAC of TMHM (TMHM-OAC) displays advantageous therapeutic action again...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.08.044

    authors： Yang N,Dong Z,Tian G,Zhu M,Li C,Bu W,Chen J,Hou X,Liu Y,Wang G,Jia X,Di L,Feng L

    更新日期：2016-12-24 00:00:00

  • Active fraction combination from Liuwei Dihuang decoction (LW-AFC) ameliorates corticosterone-induced long-term potentiation (LTP) impairment in mice in vivo.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Liuwei Dihuang decoction (LW), a classic formula in Traditional Chinese medicine (TCM), has been used for nearly one thousand years for various diseases with characteristic features of kidney yin deficiency. LW consists of 6 herbs including Dihuang (prepared root of Rehmannia glutinosa (G...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.03.002

    authors： Huang Y,Li D,Cheng B,Liu G,Zhang YX,Zhou WX

    更新日期：2019-05-23 00:00:00

  • Syzygium cumini (L.) Skeels essential oil and its major constituent α-pinene exhibit anti-Leishmania activity through immunomodulation in vitro.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as "jambolão" in Brazil is widely used in folk medicine against leishmaniasis, inflammation, chronic diarrhea, and ulcers. It is one of the most commonly used plants for the treatment of diabetes worldwide. In previous studies, Syzyg...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.11.024

    authors： Rodrigues KA,Amorim LV,Dias CN,Moraes DF,Carneiro SM,Carvalho FA

    更新日期：2015-02-03 00:00:00

  • The protective effect of the active components of ERPC on diabetic peripheral neuropathy in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Euonymus alatus, Radix trichosanthis, Panax notoginseng and Coptis chinensis are popular plants used in traditional Chinese medicine to treat diabetes. AIM OF THE STUDY:The aim of the study is to investigate the therapeutic effect of the active components of Euonymus alatus, Radix tricho...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.03.015

    authors： Hao GM,Liu YG,Wu Y,Xing W,Guo SZ,Wang Y,Wang ZL,Li C,Lv TT,Wang HL,Shi TJ,Wang W,Han J

    更新日期：2017-04-18 00:00:00

  • Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The rhizomes of Kaempferia parviflora Wall. ex Baker have been traditionally used in Thailand to treat abscesses, gout, and peptic ulcers. AIM:Previously, we reported that the chloroform fraction of a Kaempferia parviflora extract had an inhibitory effect on rat paw-edema. In the present...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.01.013

    authors： Sae-Wong C,Matsuda H,Tewtrakul S,Tansakul P,Nakamura S,Nomura Y,Yoshikawa M

    更新日期：2011-07-14 00:00:00

  • A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Licorice (Glycyrrhizae radix), the root of Glycyrrhiza uralensis Fisch. (Leguminosae), is mainly used to moderate the characteristics of toxic herbs in Traditional Chinese Medicine, which could be partly interpreted as detoxification. However, the underlying mechanism is still not fully e...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.12.043

    authors： Gong H,Zhang BK,Yan M,Fang PF,Li HD,Hu CP,Yang Y,Cao P,Jiang P,Fan XR

    更新日期：2015-03-13 00:00:00

  • Antinociceptive effect of the essential oil of Zingiber zerumbet in mice: possible mechanisms.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Zingiber zerumbet (L.) Smith, a wild edible ginger species or locally known as "lempoyang", commonly used in the Malays traditional medicine as an appetizer or to treat stomachache, toothache, muscle sprain and as a cure for swelling sores and cuts. AIM:The present study was conducted to...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.05.043

    authors： Khalid MH,Akhtar MN,Mohamad AS,Perimal EK,Akira A,Israf DA,Lajis N,Sulaiman MR

    更新日期：2011-09-01 00:00:00

  • Antihypertensive action of a procyanidin glycoside from Rhamnus lycioides.

    abstract：:The antihypertensive action of a procyanidin glycoside isolated from Rhamnus lycioides aerial parts was studied in spontaneously and renal hypertensive rats. This compound, like 20 micrograms/kg i.v. of captopril, produced a very clear in vivo inhibition of angiotensin I converting enzyme when given at a dose of 3 mg/...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(91)90149-8

    authors： Terencio MC,Sanz MJ,Paya M

    更新日期：1991-01-01 00:00:00

  • The protective effect of eupatilin on indomethacin-induced cell damage in cultured feline ileal smooth muscle cells: involvement of HO-1 and ERK.

    abstract：:Chronic users of non-steroidal anti-inflammatory drugs frequently develop ulcerative lesions in their intestines. The purpose of the present study was to investigate whether eupatilin, an active ingredient derived from Artemisia plants, prevents this side effect in vitro. Extracts of the whole herb of Artemisia asiati...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.03.010

    authors： Song HJ,Shin CY,Oh TY,Sohn UD

    更新日期：2008-06-19 00:00:00

  • Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as "Marcela" or "Macela". The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.05.014

    authors： Santin JR,Lemos M,Klein Júnior LC,Niero R,de Andrade SF

    更新日期：2010-07-20 00:00:00

  • Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots.

    abstract：:Acyl-coenzyme A: cholesterol acyltransferase (ACAT) esterifies free cholesterol in the liver and the intestine. It has relations with production of lipoproteins and accumulation of cholesteryl esters of the atheroma. Therefore, ACAT inhibitors may act as antihypercholesterolemic and antiatherosclerotic agents. One iso...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.10.012

    authors： Choi JH,Rho MC,Lee SW,Kwon OE,Park HR,Kang JY,Lee SH,Lee HS,Bae KH,Kim YK

    更新日期：2007-04-04 00:00:00

  • Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Polygonum capitatum is a well-known Miao medicinal plant that has been used for many years for its unique therapeutic effects on various urological disorders, including urinary calculus and urinary tract infections. To investigate the effect of Polygonum capitatum on cytochrome P450 (CYP)...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.10.031

    authors： Zheng L,Lu Y,Cao X,Huang Y,Liu Y,Tang L,Liao SG,Wang AM,Li YJ,Lan YY,Wang YL

    更新日期：2014-12-02 00:00:00

  • A Hausa herbal pharmacopoeia: biomedical evaluation of commonly used plant medicines.

    abstract：:Biochemical analysis of a selected sample of the Hausa (northern Nigeria) medicinal flora is presented in order to assess potential chemotherapeutic values. Laboratory investigation, supplemented by previously published phytochemical constituent analyses of pertinent taxa, suggests that a number of disorders can be ef...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(81)90021-0

    authors： Etkin NL

    更新日期：1981-07-01 00:00:00

  • Immunomodulatory activity of the rhizomes of Impatiens pritzellii var. hupehensis on collagen-induced arthritis mice.

    abstract：:Impatiens pritzellii Hook. f. var. hupehensis Hook. f. (Balsaminaceae) has been well-known and widely used in China as an anti-rheumatoid arthritis (anti-RA) herb. In this present study, mice with collagen-induced arthritis (CIA) have been treated with the methanol (MeOH) extract (0.56, 1.12, 1.68 and 2.24 g/kg body w...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.08.026

    authors： Zhou X,Zhao X,Tang L,Zhang Y,Ruan H,Pi H,Qiu J,Wu J

    更新日期：2007-02-12 00:00:00

  • Anti-inflammatory effects of Z23 on LPS-induced inflammatory responses in RAW264.7 macrophages.

    abstract：AIM OF THE STUDY:Fissistigma oldhamii (Hemsl.) Merr, a traditional Chinese herb medicine, is used for treating rheumatoid arthritis in China. In our previous study, an effective compound, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl) ethyl] propenamide (Z23), from this herb has showed potent immunosuppressive effects...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2008.09.026

    authors： Hu XD,Yang Y,Zhong XG,Zhang XH,Zhang YN,Zheng ZP,Zhou Y,Tang W,Yang YF,Hu LH,Zuo JP

    更新日期：2008-12-08 00:00:00

  • Ethnomedicinal uses of Momordicacharantia (Cucurbitaceae) in Togo and relation to its phytochemistry and biological activity.

    abstract：:Investigation of the traditional uses of Momordica charantia (Cucurbitaceae) in Togo (West Africa) showed that it is one of the most important local medicinal plants both for ritual and ethnomedical practices. There was a high degree of consensus (>50%) for use in the treatment of gastrointestinal and viral disease am...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.08.009

    authors： Beloin N,Gbeassor M,Akpagana K,Hudson J,de Soussa K,Koumaglo K,Arnason JT

    更新日期：2005-01-04 00:00:00

  • Ginkgo biloba extracts for tinnitus: More hype than hope?

    abstract：:The investigation into the effects of Ginkgo biloba extracts on tinnitus has suffered from a dearth of effective animal models as well as systematic clinical trials employing double-blind and placebo-controlled designs. Some clinical trials have yielded positive results, however, these studies are few and have been li...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2005.05.032

    authors： Smith PF,Zheng Y,Darlington CL

    更新日期：2005-08-22 00:00:00

  • Evaluation of the anti-inflammatory properties of Dodonaea polyandra, a Kaanju traditional medicine.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Extracts of the medicinal plant species Dodonaea polyandra were investigated as part of a collegial research partnership between Northern Kaanju traditional owners represented by Chuulangun Aboriginal Corporation (centred on the Wenlock and Pascoe Rivers, Cape York Peninsula, Queensland, ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2010.07.012

    authors： Simpson B,Claudie D,Smith N,Wang J,McKinnon R,Semple S

    更新日期：2010-10-28 00:00:00

  • Investigation of anti-asthmatic potential of Kanakasava in ovalbumin-induced bronchial asthma and airway inflammation in rats.

    abstract：ETHNO-PHARMACOLOGICAL RELEVANCE:Kanakasava is an Indian traditional Ayurvedic formulation containing Datura (Datura metel), Vasaca (Adhatoda vasica), Dhataki (Woodfordia fruticosa) and Grape (Vitis vinifera) extracts as major constituents and used to treat pulmonary diseases including coughing, breathing difficulty and...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.07.082

    authors： Arora P,Ansari SH,Anjum V,Mathur R,Ahmad S

    更新日期：2017-02-02 00:00:00

  • Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model.

    abstract：UNLABELLED:The popular medicine Passiflora edulis has been used as a sedative, tranquilizer, against cutaneous inflammatory diseases and intermittent fever. Most of the pharmacological investigations of Passiflora edulis have been addressed to its Central Nervous System activities, such as anxiolytic, anticonvulsant an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2006.07.031

    authors： Montanher AB,Zucolotto SM,Schenkel EP,Fröde TS

    更新日期：2007-01-19 00:00:00

  • Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis.

    abstract：AIM OF THE STUDY:Sinomenine, an alkaloid isolated from the root of Sinomenium acutum, has been used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), composed of the herbs Rhizoma Atractylodis (Cangzhu) and Cotex Phellodendri (Huangbai), is another traditional Chinese medicine formula for rheumatoi...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.05.048

    authors： Chen DP,Wong CK,Leung PC,Fung KP,Lau CB,Lau CP,Li EK,Tam LS,Lam CW

    更新日期：2011-09-01 00:00:00

  • Effect of oral administration of bark extracts of Pterocarpus santalinus L. on blood glucose level in experimental animals.

    abstract：:The effect of administration of different doses of Pterocarpus santalinus L. bark extracts in normal and diabetic rats, on blood glucose levels was evaluated in this study. Among the three fractions (aqueous, ethanol and hexane), ethanolic fraction at the dose of 0.25 g/kg body weight showed maximum antihyperglycemic ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(00)00344-5

    authors： Kameswara Rao B,Giri R,Kesavulu MM,Apparao C

    更新日期：2001-01-01 00:00:00

  • Evaluation of the mutagenic and antimutagenic effects of South African plants.

    abstract：:Dichloromethane and 90% methanol extracts of 42 South African plants were screened for mutagenicity and antimutagenicity using the Salmonella/microsome mutagenicity assay (Ames) against Salmonella typhimurium TA98 and TA100 bacterial strains in the presence and absence of metabolic activator S9. The methanol extracts ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.11.030

    authors： Reid KA,Maes J,Maes A,van Staden J,De Kimpe N,Mulholland DA,Verschaeve L

    更新日期：2006-06-15 00:00:00

  • Anti-inflammatory activities of flavonoids of Baphia nitida Lodd. (Leguminosae) on mice and rats.

    abstract：:Leaves of Baphia nitida are used in folk medicine for the treatment of inflamed and infected umbilical cords in Nigeria. Phytochemical analysis of the leaves detected tannins, flavonoids and saponin glycosides. Flavonoid rich fraction of the leaf, obtained by a chromatographic process, was formulated into an ointment ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(94)01221-k

    authors： Onwukaeme ND

    更新日期：1995-05-01 00:00:00

  • Antimicrobial and anti-inflammatory activity of folklore: Mallotus peltatus leaf extract.

    abstract：:Since ages Mallotus peltatus (Geist) Muell. Arg. var acuminatus (Euphorbiaceae) leaf and stem bark is used in folk medicine to cure intestinal ailments and skin infections. In several intestinal ailments, localized inflammation is of common occurrence and hence we have evaluated the antimicrobial as well as anti-infla...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00165-4

    authors： Chattopadhyay D,Arunachalam G,Mandal AB,Sur TK,Mandal SC,Bhattacharya SK

    更新日期：2002-10-01 00:00:00

  • A history of the therapeutic use of liquorice in Europe.

    abstract：:Liquorice root has been used in Europe since prehistoric times, and is well documented in written form starting with the ancient Greeks. In this review we compare the independent development of medical uses of this botanical drug in several ancient cultures, attempting to show the rationality of specific indications a...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.jep.2005.04.015

    authors： Fiore C,Eisenhut M,Ragazzi E,Zanchin G,Armanini D

    更新日期：2005-07-14 00:00:00

  • Lythrum salicaria L. herb and gut microbiota of healthy post-weaning piglets. Focus on prebiotic properties and formation of postbiotic metabolites in ex vivo cultures.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Herb of purple loosestrife (Lythrum salicaria L. from Lythraceae family) (LSH) was used in Europe since ancient times till early-20th century in the therapy of diarrhea and dysentery in human and veterinary medicine. Post-weaning diarrhea is a main problem affecting global piglet producti...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113073

    authors： Dadi TH,Vahjen W,Zentek J,Melzig MF,Granica S,Piwowarski JP

    更新日期：2020-10-28 00:00:00

  • Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: a review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The present study has indicated phytochemical composition, distribution and ethno-medicinal uses of Arnebia euchroma (Royle) I.M. Johnst, which is commonly known as "Ratanjot" in the Indian subcontinent. It has widely been used in the traditional systems of the Unani, Ayurvedic and Chines...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2021.113896

    authors： Kumar A,Shashni S,Kumar P,Pant D,Singh A,Verma RK

    更新日期：2021-01-29 00:00:00