Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:Extracts of the medicinal plant species Dodonaea polyandra were investigated as part of a collegial research partnership between Northern Kaanju traditional owners represented by Chuulangun Aboriginal Corporation (centred on the Wenlock and Pascoe Rivers, Cape York Peninsula, Queensland, Australia) and university-based researchers. D. polyandra, known as "Uncha" in Kaanju language, is used in Northern Kaanju Traditional Medicine for relief from pain associated with toothache and related ailments. The species has a restricted distribution in Cape York Peninsula and there has been no previous Western scientific investigation of its pharmacology or chemistry. AIM OF THE STUDY:The current study investigates the anti-inflammatory effects of several extracts from D. polyandra. MATERIALS AND METHODS:Phytochemical screening was conducted using TLC. Anti-inflammatory effects of leaf extracts were determined using an acute mouse ear oedema model induced by croton oil and 12-o-tetradecanoylphorbol-13-acetate (TPA) chemical irritants. RESULTS:Flavonoid and terpenoid secondary compounds were detected in leaf extracts of D. polyandra. Non-polar hexane and methylene chloride/methanol extracts showed potent inhibition of inflammation in TPA-induced mouse ear oedema by 72.12 and 79.81%, respectively, after 24 h at 0.4 mg/ear. CONCLUSION:In a mouse model of acute inflammation, this study revealed that leaf extracts of D. polyandra possess significant anti-inflammatory potential. These results contribute to a Western scientific understanding of the ethnopharmacological use of the plant in Northern Kaanju Medicine for reducing tooth-related pain.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Simpson B,Claudie D,Smith N,Wang J,McKinnon R,Semple Sdoi
10.1016/j.jep.2010.07.012subject
Has Abstractpub_date
2010-10-28 00:00:00pages
340-3issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(10)00474-5journal_volume
132pub_type
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