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Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots.

Abstract：

:Acyl-coenzyme A: cholesterol acyltransferase (ACAT) esterifies free cholesterol in the liver and the intestine. It has relations with production of lipoproteins and accumulation of cholesteryl esters of the atheroma. Therefore, ACAT inhibitors may act as antihypercholesterolemic and antiatherosclerotic agents. One isoprenyl flavonoid was isolated from ethanol extract of licorice roots. On the basis of spectral evidences, the compound was identified as glabrol (1). Compound 1 inhibited rat liver microsomal ACAT activity with an IC(50) value of 24.6 microM and decreased cholesteryl ester formation with an IC(50) value of 26.0 microM in HepG2 cells. In addition, 1 showed a non-competitive type of inhibition against ACAT.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Choi JH,Rho MC,Lee SW,Kwon OE,Park HR,Kang JY,Lee SH,Lee HS,Bae KH,Kim YK

doi

10.1016/j.jep.2006.10.012

subject

Has Abstract

pub_date

2007-04-04 00:00:00

pages

563-6

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(06)00527-7

journal_volume

110

pub_type

杂志文章

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