Abstract：
AIM OF THE STUDY:The leaves of Costus pictus D. Don were used extensively for its antihyperglycemic activity by the people in Kerala, India. In the present study, the antihyperglycemic and insulin secretory activity of an aqueous extract of Costus pictus leaf extract was investigated in streptozotocin induced diabetic rats. MATERIALS AND METHODS:Oral Glucose Tolerance Test was done to determine the effective dose of Costus pictus extract. Aqueous extract of Costus pictus leaves was given orally to the diabetic rats for 14 days. The insulin secretory action of the leaf extract was investigated using isolated pancreatic islets from rat. Liver glucose uptake activity was measured using D-[14C] glucose. RESULTS:The oral administration of an aqueous extract of Costus pictus at a dose of 250 mg/kg body weight significantly decreased the blood glucose with significant increase in plasma insulin level in diabetic rats at the end of 14 days treatment. The Costus pictus leaf extract significantly increased glucose induced insulin secretion at both 4 mM and 20 mM glucose concentrations which represents normal physiological and diabetic condition respectively. The decreased glucose uptake activity of the liver of diabetic rats was reverted to near normal levels after the treatment with Costus pictus leaf extract. CONCLUSION:Our results suggest the glucose lowering effect of Costus pictus to be associated with the potentiation of insulin release from pancreatic islets and enhancement of peripheral utilization of glucose.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Gireesh G,Thomas SK,Joseph B,Paulose CSdoi
10.1016/j.jep.2009.03.026subject
Has Abstractpub_date
2009-06-25 00:00:00pages
470-4issue
3eissn
0378-8741issn
1872-7573pii
S0378-8741(09)00159-7journal_volume
123pub_type
杂志文章abstract：:One hundred informants including full time/part time herbalists, old ladies, family heads and village heads were interviewed for the type of plants used in their homes for the treatment of some common diseases. Forty eight plant species were found to be used by Ondo people in folk medicine. Fourteen species were found...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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abstract：:Prof. Philippe Rasoanaivo was a highly dedicated and brilliant scientist in the field of ethnopharmacology. He worked for the Institut Malgache de Recherches Appliquées and the University of Antananarivo, Madagascar. His research was mainly focused on the endemic medicinal and aromatic plants used by traditional heale...
journal_title：Journal of ethnopharmacology
pub_type： 传,社论,历史文章
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2013-01-09 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2008-03-05 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2009-07-30 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2007-12-03 00:00:00
abstract：INTRODUCTION:Mirabilis jalapa Linn is a well-studied plant. The indigenous people of Mexico use Mirabilis jalapa to cure many infirmities including dysentery, diarrhea, muscular pain and abdominal colic. In the present investigation, we have further characterized some pharmacological properties of an extract of Mirabil...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2007.11.004
更新日期：2008-02-28 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Most cardiovascular diseases ultimately result in heart failure, an intractable problem in modern medicine. Yangxinshi tablet (YXS) is a Chinese medicine formula that is used clinically to treat coronary heart disease. However, the active compounds, potential targets, and pharmacological ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2019.112227
更新日期：2020-01-10 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The root of Peucedanum japonicum Thunberg is traditionally used to treat coughs, colds, headache and inflammatory diseases in Korea and Japan. Its effects on allergic lung inflammation have not been investigated. AIM OF THE STUDY:To investigate the anti-asthmatic effects of Peucedanum ja...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.09.006
更新日期：2018-01-30 00:00:00
