Abstract：
AIM OF THE STUDY:Epilepsy is a common clinical syndrome with recurrent neuronal discharges in cerebral cortex and hippocampus. Here we aim to determine the protective role of Uncaria rhynchophylla (UR), an herbal drug belong to Traditional Chinese Medicine (TCM), on epileptic rats. MATERIALS AND METHODS:To address this issue, we tested the effect of UR on kainic acid (KA)-induced epileptic seizures and further investigate the underlying mechanisms. RESULTS:Oral UR successfully decreased neuronal death and discharges in hippocampal CA1 pyramidal neurons. The population spikes (PSs) were decreased from 4.1 ± 0.4 mV to 2.1 ± 0.3 mV in KA-induced epileptic seizures and UR-treated groups, respectively. Oral UR protected animals from neuronal death induced by KA treatment (from 34 ± 4.6 to 191.7 ± 48.6 neurons/field) through attenuating glial cell proliferation and S100B protein expression but not GABAA and TRPV1 receptors. CONCLUSIONS:The above results provide detail mechanisms underlying the neuroprotective action of UR on KA-induced epileptic seizure in hippocampal CA1 neurons.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Lin YW,Hsieh CLdoi
10.1016/j.jep.2011.03.018subject
Has Abstractpub_date
2011-05-17 00:00:00pages
313-20issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(11)00154-1journal_volume
135pub_type
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