Abstract：
AIM OF THE STUDY:Depression is a severe mood disorder. It was treated with Shudihuang, the steamed roots of Rehmannia glutinota Libosch. (SRG), in traditional Chinese medicine. The present paper was designed to verify its antidepressant effect. MATERIALS AND METHODS:A mouse model of depression was established though unpredictable chronic mild stress (UCMS). Low and high doses of SRG were administered orally. Fur state, body and organ weight, and gastric ulcers were examined. Locomotion was assayed in open field test. Liver antioxidant indexes were measured spectrophotometrically. RESULTS:Fur state, body and organ weight were found to be insensitive to UCMS. The locomotion reduced by UCMS was restored by low dose of SRG (2.5 g/kg BW) but not by high dose (5 g/kg BW). UCMS resulted in aggravated gastric ulceration, elevated liver malondialdehyde, together with reduced total antioxidant capability, glutathione content, and superoxide dismutase and catalase activities. The alterations were improved by SRG in a dose-dependent manner. The differences in the activity of glutathione peroxidase were statistically nonsignificant among groups. Clomipramine the positive drug was similar to SRG especially in antioxidation. CONCLUSION:SRG is of therapeutic value for depression-like disorders, and antioxidation may be one of the mechanisms underlying its antidepressant action.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Zhang D,Wen XS,Wang XY,Shi M,Zhao Ydoi
10.1016/j.jep.2009.02.029subject
Has Abstractpub_date
2009-05-04 00:00:00pages
55-60issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(09)00121-4journal_volume
123pub_type
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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pub_type： 杂志文章,评审
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：1987-03-01 00:00:00
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journal_title：Journal of ethnopharmacology
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