当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat.

Vasodilating and hypotensive effects of fangchinoline and tetrandrine on the rat aorta and the stroke-prone spontaneously hypertensive rat.

Abstract：

:Comparative studies of the effects of tetrandrine (TET) and fangchinoline (FAN), two major components of the Radix of Stephannia tetrandrae, on vasodilations and on calcium movement in vascular smooth muscle, and studies of hypotensive effects on stroke-prone spontaneously hypertensive rats (SHRSP) were performed in the following experiments. TET and FAN inhibited high K+ (65.4 mM) and induced sustained contraction in the rat aorta smooth muscle strips. IC50 values for TET and FAN were 0.27 +/- 0.05 microM (n = 6) and 9.53 +/- 1.57 microM (n = 6), respectively, and this inhibition was antagonized by increasing the Ca2+ concentration in the medium. The IC50 of TET for norepinephrine (NE)-induced contraction (0.86 +/- 0.04 g) was 3.08 +/- 0.05 microM (n = 4), and the IC50 of FAN for NE-induced contraction (0.88 +/- 0.07 g) was 14.20 +/- 0.40 microM (n = 4). At the molecular level, radiolabelled 45Ca2+ uptake tests revealed that TET and FAN also inhibited high K+ (65.4 mM) and 1 microM NE-stimulated Ca2+ influx in rat aorta strips at the maximal concentration was needed to inhibit the contraction. TET (3 mg/kg) and FAN (30 mg/kg) administered by intravenous (i.v.) bolus injection also lowered the mean arterial pressure (MAP) significantly during the period of observation in conscious SHRSP, respectively. These results showed that TET was more potent than FAN in blocking calcium channels and antihypertensive activity.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Kim HS,Zhang YH,Oh KW,Ahn HY

doi

10.1016/s0378-8741(97)00092-5

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

117-23

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(97)00092-5

journal_volume

58

pub_type

杂志文章

相关文献

JOURNAL OF ETHNOPHARMACOLOGY文献大全
  • Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:According to Traditional Chinese Medicine theory, influenza is categorized as a warm disease or Wen Bing. The Wen Bing formulas, such as Yin-Qiao-San and Sang-Ju-Yin, are still first-line herbal therapies in combating variant influenza virus. To continue our study on the pharmacokinetic a...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2019.112097

    authors： Zhang Y,Lyu C,Fong SYK,Wang Q,Li C,Ho NJ,Chan KS,Yan X,Zuo Z

    更新日期：2019-10-28 00:00:00

  • Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus.

    abstract：:Prunus persica L. BATSCH seed-water extract (PPE) has been used in the treatment of the degenerative disorders, such as hypermenorrhea and dysmenorrhea, in Taiwan, China, Japan and Korea. In this study, the effects of oral administration of PPE on the extracellular acetylcholine concentration in the hippocampus of rat...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00106-5

    authors： Kim YK,Koo BS,Gong DJ,Lee YC,Ko JH,Kim CH

    更新日期：2003-08-01 00:00:00

  • Terminalia catappa L. infusion accelerates the healing process of gastric ischemia-reperfusion injury in rats.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Terminalia catappa L. (Combretaceae), known as "amendoeira da praia" in Brazil, has been recognized as a medicinal plant in folk medicine for the treatment of gastrointestinal disorders and other inflammatory conditions. The present study aimed to investigate the preventive and healing ef...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.112793

    authors： Ohara R,Périco LL,Rodrigues VP,Bueno G,Zanatta AC,Campaner Dos Santos L,Vilegas W,Constatino FB,Justulin LA,Hiruma-Lima CA

    更新日期：2020-06-28 00:00:00

  • Traditional Korean herbal formulae, Yuk-Mi-Ji-Hwang-Tang, ameliorates impairment of hippocampal memory ability by chronic restraint stress of mouse model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Yuk-Mi-Jihwang-Tang (YJT) has been popularly prescribed to treat aging related disorders over than hundreds of years in East Asia countries. AIM OF THE STUDY:To investigate possible modulatory actions of YJT on chronic restraint stress (CRS)-induced neurodegeneration on hippocampus neuro...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113102

    authors： Eom TM,Kwon HH,Shin N,Kim DW,Fang Z,Seol IC,Kim YS,Kim HG,Yoo HR

    更新日期：2020-10-05 00:00:00

  • Antimicrobial activity of some important Adiantum species used traditionally in indigenous systems of medicine.

    abstract：:Adiantum Linn. of Adiantaceae family is one of the most common and widely distributed species. Ethnomedicinally, the genus is important and popularly known as "Hansraj" in Ayurvedic System of Medicine. It has been used in cold, tumors of spleen, liver and other viscera, skin diseases, bronchitis and inflammatory disea...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.09.018

    authors： Singh M,Singh N,Khare PB,Rawat AK

    更新日期：2008-01-17 00:00:00

  • Antimicrobial activity of the methanolic extract, fractions and four flavonoids from the twigs of Dorstenia angusticornis Engl. (Moraceae).

    abstract：:The methanolic extract (DAT), fractions (FRS) and four flavonoids, namely Gancaonin Q (1), Stipulin (2), Angusticornin B (3) and Bartericin A (4), isolated from the twigs of Dorstenia angusticornis (Moraceae), were tested for their in vitro antimicrobial activity. A total of 22 microbial cultures belonging to three Ca...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.03.008

    authors： Kuete V,Simo IK,Ngameni B,Bigoga JD,Watchueng J,Kapguep RN,Etoa FX,Tchaleu BN,Beng VP

    更新日期：2007-06-13 00:00:00

  • Immunoregulatory effects of glycyrrhizic acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4(+)CD25(+)Foxp3+ regulatory T cells in ovalbumin-sensitized mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Glycyrrhizic acid (GA) is the main bioactive ingredient of licorice (Glycyrrhiza glabra), and has been found to be associated with multiple therapeutic properties. AIM OF THE STUDY:In this study, we investigated immunoregulatory effects of glycyrrhizic acid on anti-asthmatic effects and ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2013.04.021

    authors： Ma C,Ma Z,Liao XL,Liu J,Fu Q,Ma S

    更新日期：2013-07-30 00:00:00

  • Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats.

    abstract：:The lipid lowering activity (LLA) of Phyllanthus niruri has been studied in triton and cholesterol fed hyperlipemic rats. Serum lipids were lowered by P. niruri extract orally fed (250 mg/kg b.w.) to the triton WR-1339 induced hyperlipemic rats. Chronic feeding of this drugs (100 mg/kg b.w.) in animals simultaneously ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(02)00136-8

    authors： Khanna AK,Rizvi F,Chander R

    更新日期：2002-09-01 00:00:00

  • Bioactive alkyl phenols and embelin from Oxalis erythrorhiza.

    abstract：:The benzoquinone embelin and four alkyl phenols were isolated from an Argentinean collection of Oxalis erythrorhiza. 3-Heptadecyl-5-methoxy-phenol is reported for the first time. The structures were determined by spectroscopic methods. Embelin presented inhibitory effect on methicillin-resistant Staphylococcus aureus,...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(03)00258-7

    authors： Feresin GE,Tapia A,Sortino M,Zacchino S,de Arias AR,Inchausti A,Yaluff G,Rodriguez J,Theoduloz C,Schmeda-Hirschmann G

    更新日期：2003-10-01 00:00:00

  • A standardized extract of Rhynchosia volubilis Lour. exerts a protective effect on benzalkonium chloride-induced mouse dry eye model.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In contrast to other leguminous plants generally used as food, Rhynchosia volubilis Loureiro, a small soybean with a black seed coat, has been used as a traditional oriental remedy for various human diseases in Eastern Asia. In this study, we demonstrated the protective effect of R. volub...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.12.041

    authors： Kang SW,Kim KA,Lee CH,Yang SJ,Kang TK,Jung JH,Kim TJ,Oh SR,Jung SH

    更新日期：2018-04-06 00:00:00

  • Screening of some medicinal plants for anti-lipase activity.

    abstract：:In order to find new pancreatic lipase (triacylglycerol lipase, EC 3.1.1.3) inhibitors from natural sources, 75 medicinal plants belonging to different families were screened for their anti-lipase activity, using a radioactive method. On evaluating the results, methanolic extracts of three plants namely, Eriochloa vil...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.11.009

    authors： Sharma N,Sharma VK,Seo SY

    更新日期：2005-03-21 00:00:00

  • Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats.

    abstract：:Jigrine a polypharmaceutical herbal hepatoprotective formulation containing aqueous extracts of 14 medicinal plants is used in Indian system of medicine (Unani). Jigrine was evaluated for its hepatoprotective activity against galactosamine induced hepatopathy in rats. Galactosamine induced hepatotoxicity resembles hum...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2004.12.016

    authors： Najmi AK,Pillai KK,Pal SN,Aqil M

    更新日期：2005-03-21 00:00:00

  • Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4/MyD88/NF-κB and TGF-β/smads signaling pathways.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Forsythiae Fructuse water extract (FSE) is a water-soluble component extracted from the traditional Chinese medicine Forsythiae Fructuse (The fruit of Forsythia suspensa (Thunb.) Vahl) usually used to treat inflammatory diseases. However, little is known about the therapeutic effect of FS...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2020.113275

    authors： Hu N,Guo C,Dai X,Wang C,Gong L,Yu L,Peng C,Li Y

    更新日期：2020-11-15 00:00:00

  • Amburana cearensis seed extract protects brain mitochondria from oxidative stress and cerebellar cells from excitotoxicity induced by glutamate.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Amburana cearensis (Allemao) A.C.Sm. is a medicinal plant of the Brazilian Caatinga reported to present antioxidant and anti-inflammatory activity. This study aimed to evaluate the neuroprotective effect of the extracts obtained from the seeds of A. cearensis in primary cultures of cerebe...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2017.07.017

    authors： Lima Pereira ÉP,Santos Souza C,Amparo J,Short Ferreira R,Nuñez-Figueredo Y,Gonzaga Fernandez L,Ribeiro PR,Braga-de-Souza S,Amaral da Silva VD,Lima Costa S

    更新日期：2017-09-14 00:00:00

  • A RNA-seq approach for exploring the protective effect of ginkgolide B on glutamate-induced astrocytes injury.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:There is substantial experimental evidence to support the view that Ginkgo biloba L. (Ginkgoaceae), a traditional Chinese medicine known to treating stroke, has a protective effect on the central nervous system and significantly improves the cognitive dysfunction caused by disease, includ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2021.113807

    authors： Wang J,Zhuang L,Ding Y,Wang Z,Xiao W,Zhu J

    更新日期：2021-01-12 00:00:00

  • In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in mice.

    abstract：:Extracts obtained from two Burkinabe folk medicine plants, spiny amaranth (Amaranthus spinosus L., Amaranthaceae) and erect spiderling (Boerhaavia erecta L., Nyctagynaceae) were screened for antimalarial properties with the aim of testing the validity of their traditional uses. The plant extracts showed significant an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2005.08.006

    authors： Hilou A,Nacoulma OG,Guiguemde TR

    更新日期：2006-01-16 00:00:00

  • Merging pharmacopoeia: understanding the historical origins of incorporative pharmacopoeial processes among Xhosa healers in southern Africa.

    abstract：:This paper focusses on Xhosa healers and their pharmacopoeias in Southern Africa. Its preliminary aim is to show that Xhosa healers have incorporated Western pharmaceutical products into their traditional dispensaries. The primary aim of the paper is to explain the trend towards medicinal incorporation in terms of the...

    journal_title：Journal of ethnopharmacology

    pub_type： 历史文章,杂志文章

    doi：10.1016/0378-8741(91)90083-p

    authors： Simon C,Lamla M

    更新日期：1991-07-01 00:00:00

  • The traditional uses, phytochemistry, and pharmacology of Stemona species: A review.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Plants of genus Stemona (Stemonaceae) have been long used locally and traditionally in many South and East Asian counties to relieve cough, dispel phlegm, prevent asthma, control pests, diminish inflammation, decrease pain, and treat some cutaneous diseases. AIM OF STUDY:This review prov...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jep.2020.113112

    authors： Liu Y,Shen Y,Teng L,Yang L,Cao K,Fu Q,Zhang J

    更新日期：2021-01-30 00:00:00

  • Effects of Hemerocallis flava on motor activity and the concentration of central monoamines and its metabolites in rats.

    abstract：:In this study, we used behavioral and biochemical methods to investigate the effects of Hemerocallis flava (Liliaceae) (abbreviated as HF) on motor activity and the concentration of monoamines in rats. The water fraction of the resuspended HF extract was most active in reducing the motility in rats. The water fraction...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/0378-8741(96)01388-8

    authors： Hsieh MT,Ho YF,Peng WH,Wu CR,Chen CF

    更新日期：1996-06-01 00:00:00

  • Evidence-based Chinese medicine for cancer therapy.

    abstract：:In contrast to western medicine (WM), traditional Chinese medicine (TCM) does not focus on a single target but on multiple targets involved in a particular disease condition by applying diverse modalities, such as herbal medicine, acupuncture, moxibustion, etc. There is no pre-determined treatment procedure in TCM, an...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.12.009

    authors： Konkimalla VB,Efferth T

    更新日期：2008-03-05 00:00:00

  • Various uses of the castor oil plant (Ricinus communis L.). A review.

    abstract：:The ancient and modern medicinal uses of the castor bean plant, Ricinus communis L. (Euphorbiaceae), in about fifty countries worldwide, has been surveyed. The different medicinal uses are grouped separately in relation to their pharmacological action, whether real or presumed, within the various medical specialties. ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/0378-8741(82)90038-1

    authors： Scarpa A,Guerci A

    更新日期：1982-03-01 00:00:00

  • Evaluation of Nigerian traditional medicine: effects of Gakani, a herbal anti-asthmatic drug.

    abstract：:The anti-asthmatic potential of Gakani, a popular herbal drug in Nigeria was investigated. The LD50 values of the freeze-dried aqueous extract in mice and rats were 20.9 +/- 2.4 mg/kg and 18.6 +/- 4 mg/kg, respectively. The extract unsurmountably blocked the effects of histamine and isoprenaline on the guinea pig trac...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/s0378-8741(96)01475-4

    authors： Akah PA,Gamaniel KS,Samson A,Wambebe CO

    更新日期：1997-01-01 00:00:00

  • Antihyperglycemic and insulin secretory activity of Costus pictus leaf extract in streptozotocin induced diabetic rats and in in vitro pancreatic islet culture.

    abstract：AIM OF THE STUDY:The leaves of Costus pictus D. Don were used extensively for its antihyperglycemic activity by the people in Kerala, India. In the present study, the antihyperglycemic and insulin secretory activity of an aqueous extract of Costus pictus leaf extract was investigated in streptozotocin induced diabetic ...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2009.03.026

    authors： Gireesh G,Thomas SK,Joseph B,Paulose CS

    更新日期：2009-06-25 00:00:00

  • Xuefuzhuyu decoction inhibition of angiogenesis attenuates liver fibrosis induced by CCl₄ in mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Xuefuzhuyu decoction (XFZY) is a well-known traditional Chinese herbal formulation composed of 11 herbs. It is an effective treatment for cardiovascular and chronic liver diseases. The aim of the study is to investigate the role of XFZY on angiogensis in hepatic fibrogenesis, and identify...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2014.03.019

    authors： Zhou YN,Sun MY,Mu YP,Yang T,Ning BB,Ren S,Chen JM,Liu P

    更新日期：2014-05-14 00:00:00

  • Wuling San protects kidney dysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasome activation in high fructose-induced hyperuricemic mice.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Wuling San, a famous prescription in Chinese medicine, is composed of Polyporus, Poria, Alismatis rhizoma, Cinnamomi cortex and Atractylodis macrocephalae rhizoma, and promotes kidney function and diuresis. The main purpose of this study was to investigate its renal protective effect in h...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.011

    authors： Yang Y,Zhang DM,Liu JH,Hu LS,Xue QC,Ding XQ,Kong LD

    更新日期：2015-07-01 00:00:00

  • Parkinsonia aculeata (Caesalpineaceae) improves high-fat diet-induced insulin resistance in mice through the enhancement of insulin signaling and mitochondrial biogenesis.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The search for natural agents that minimize obesity-associated disorders is receiving special attention. Parkinsonia aculeata L. (Caesalpineaceae) has long been used in Brazil as a hypoglycaemic herbal medicine, without any scientific basis. AIMS OF THE STUDY:In this context, we aimed to...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2016.02.048

    authors： Araújo TG,de Oliveira AG,Vecina JF,Marin RM,Franco ES,Abdalla Saad MJ,de Sousa Maia MB

    更新日期：2016-05-13 00:00:00

  • Bridging the "two cultures" in ethnopharmacology: barriers against interdisciplinarity in postgraduate education.

    abstract：:As significant contributors to the generation, dissemination and publication of scientific knowledge, graduate students have considerable leverage on publication trends and the future direction of ethnopharmacology. The rigid discipline-oriented framework of academia is often cited as responsible for impeding interdis...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2011.01.053

    authors： Owen PL,Johns T,Etkin NL

    更新日期：2011-04-12 00:00:00

  • Phellinus linteus inhibits inflammatory mediators by suppressing redox-based NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophage.

    abstract：:The mushroom Phellinus linteus has been known to exhibit potent biological activity. In contrast to the immuno-potentiating properties of Phellinus linteus, the anti-inflammatory properties of Phellinus linteus have rarely been investigated. Recently, ethanol extract and n-BuOH fractions from Phellinus linteus were de...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2007.08.011

    authors： Kim HG,Yoon DH,Lee WH,Han SK,Shrestha B,Kim CH,Lim MH,Chang W,Lim S,Choi S,Song WO,Sung JM,Hwang KC,Kim TW

    更新日期：2007-12-03 00:00:00

  • Antidiabetic, anti-oxidant and antimicrobial activities of Fadogia ancylantha extracts from Malawi.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Communities in Chilumba, Malawi use herbal tea prepared from Fadogia ancylantha Schweinf (Rubiaceae) leaves for the management of diabetes, hypertension and alleviation of symptoms of gastrointestinal disorders and pneumonia. The objective of the study was to evaluate the in vitro antidia...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2012.07.002

    authors： Nyirenda KK,Saka JD,Naidoo D,Maharaj VJ,Muller CJ

    更新日期：2012-08-30 00:00:00

  • Ethnobotanical survey of medicinal plants used in the Maseru district of Lesotho.

    abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ethnobotanical knowledge in Lesotho is passed on orally from one generation to another. As a result it has not been well documented. Existing publications have relied on previous literature and are limited either in terms of scope or coverage. Furthermore, some of them are out of print. T...

    journal_title：Journal of ethnopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.jep.2015.04.047

    authors： Seleteng Kose L,Moteetee A,Van Vuuren S

    更新日期：2015-07-21 00:00:00