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Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats.

Abstract：

:The lipid lowering activity (LLA) of Phyllanthus niruri has been studied in triton and cholesterol fed hyperlipemic rats. Serum lipids were lowered by P. niruri extract orally fed (250 mg/kg b.w.) to the triton WR-1339 induced hyperlipemic rats. Chronic feeding of this drugs (100 mg/kg b.w.) in animals simultaneously fed with cholesterol (25 mg/kg b.w.) for 30 days caused lowering in the lipids and apoprotein levels of VLDL and LDL in experimental animals. The LLA of this drug is mediated through inhibition of hepatic cholesterol biosynthesis, increased faecal bile acids excretion and enhanced plasma lecithin: cholesterol acyltransferase activity.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Khanna AK,Rizvi F,Chander R

doi

10.1016/s0378-8741(02)00136-8

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

19-22

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378874102001368

journal_volume

82

pub_type

杂志文章

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