当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats.

Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats.

Abstract：

:The aqueous and alcoholic extracts of Trigonella foenum-graecum leaf were tested for hypoglycaemic activity in normal and alloxan-diabetic rats. Graded amounts (0.06, 0.2, 0.5, 1 g/kg, i.p. and 1, 2, 8 g/kg, p.o.) of the aqueous extract of Trigonella foenum-graecum leaf when given to both normal and alloxan-diabetic rats, a significant reduction of blood glucose concentration was noticed. On the other hand ethanolic extract of Trigonella foenum-graecum leaf produced no reduction in blood glucose concentration in normal rats but intra-peritoneal administration of 0.8 g/kg of the ethanolic leaf extract to diabetic rats produced a significant reduction of blood glucose concentration (p < 0.02) at 2 and 24 h only. Intraperitoneal and oral acute toxicity (LD50) and target organ effects were studied for the aqueous extract of Trigonella leaf in mice. LD50 of i.p. and oral administration were 1.9 and 10 g/kg respectively. The main organ affected after i.p. administration of the aqueous extract was the liver while oral administration of the aqueous extract of Trigonella did not produce any sign of organ damage. These results suggest that the aqueous extract of Trigonella foenum-graecum leaves given both orally and intraperitoneally possesses a hypoglycaemic effect in normoglycaemic and alloxan induced hyperglycaemic rats.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Abdel-Barry JA,Abdel-Hassan IA,Al-Hakiem MH

doi

10.1016/s0378-8741(97)00101-3

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

149-55

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378874197001013

journal_volume

58

pub_type

杂志文章

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