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In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects.

Abstract：

:Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC(50) < 100 microg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC(50) values ranging less than 30 microg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC(50) values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Muregi FW,Chhabra SC,Njagi EN,Lang'at-Thoruwa CC,Njue WM,Orago AS,Omar SA,Ndiege IO

doi

10.1016/s0378-8741(02)00327-6

keywords:

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

235-9

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378874102003276

journal_volume

84

pub_type

杂志文章

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