Abstract：
:Achyrocline satureioides (Lam.) DC. inflorescences have been used as remedies in folk medicine for the treatment of a variety of human ailments, particularly those of the gastrointestinal tract. Different extracts of inflorescences have been tested for anti-inflammatory, analgesic, antispasmodic, constipating and sedative activities. The aqueous extracts (maceration and decoction) and ethanolic macerate exhibited an inhibition of the carrageenan-induced rat paw oedema at a dose range of 75-500 mg kg-1 i.p., and also showed analgesic effect with the acetic acid-induced writhing test in mice. The gastrointestinal propulsion of a charcoal suspension was not affected significantly by any extract, at a dose of 200 mg kg-1 p.o., in mice. The aqueous decoction increased pentobarbital-induced sleeping time, at doses of 200 and 500 mg kg-1 i.p. and p.o., in mice. The ethanolic macerate inhibited contractions induced by acetylcholine, histamine, noradrenaline and barium chloride in four different smooth muscle tissues. The antispasmodic and anti-inflammatory activities were reproduced with quercetin, luteolin and quercetin 3-methyl ether, flavonoids that have been isolated from this plant. A partial evaluation of the toxicity of the extracts was also performed. The pharmacological effects assayed are discussed in relation to the chemical constituents of this plant and its popular use in gastrointestinal disturbances, and inflammatory conditions could be related to the presence of the flavonoids.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Simões CM,Schenkel EP,Bauer L,Langeloh Adoi
10.1016/0378-8741(88)90239-5subject
Has Abstractpub_date
1988-04-01 00:00:00pages
281-93issue
3eissn
0378-8741issn
1872-7573pii
0378-8741(88)90239-5journal_volume
22pub_type
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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pub_type： 杂志文章
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更新日期：1990-05-01 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2014-08-08 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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更新日期：2014-12-02 00:00:00
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更新日期：2021-02-10 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2002-01-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：1999-12-15 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2020-09-02 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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journal_title：Journal of ethnopharmacology
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更新日期：2008-03-05 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2012-06-14 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2020-07-15 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：1999-02-01 00:00:00
abstract：AIMS OF THE STUDY:In order to assess traditional Thai claims about the therapeutic potential of medicinal plants and to select plants for future phytochemical research, nine plant species with anti-inflammatory uses were selected from Thai textbooks and assessed for their in vitro anti-inflammatory, antiproliferative a...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2010-07-20 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Polygoni Multiflori Radix (PMR) and Polygoni Multiflori Radix Praeparata (PMRP) that is used after processing are two well-known traditional Chinese medicines. PMRP is traditionally reported to have lipid-reducing activity as recorded in Chinese Pharmacopoeia. AIM OF THE STUDY:This study...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112577
更新日期：2020-04-24 00:00:00
