Evaluation of contraceptive activity of methanol extract of Dendrophthoe falcata stem in male albino rats.

Abstract:

:The present study was undertaken to evaluate the contraceptive efficacy of methanol extract of Dendrophthoe falcata Ettingsh (family-Loranthaceae), stem in male albino rats as reported in folk remedies. Adult proven fertile male rats were gavaged methanol extract of D. falcata stem at 50, 100 and 200mg/rat/day for 60 days. The activity was compared with standard drug, i.e. Lonidamine. On day 61 the animals were autopsied and the testes, epididymides, seminal vesicle and ventral prostate were dissected out and weighed. Sperm motility and density and serum testosterone level were assessed. The sperm motility and density were significantly reduced. The histoarchitecture of testes revealed degenerative changes in the seminiferous tubules, arrest of spermatogenesis at the stage of round spermatid. Serum testosterone levels were decreased significantly in all treatment groups. It is concluded that D. falcata methanol stem extract showed a significant effect on fertility in male rats as reported in folk remedies.

journal_name

J Ethnopharmacol

authors

Gupta RS,Kachhawa JB

doi

10.1016/j.jep.2007.02.022

subject

Has Abstract

pub_date

2007-05-30 00:00:00

pages

215-8

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00105-5

journal_volume

112

pub_type

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