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Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Urtica circularis (Hicken) Sorarú is a medicinal plant commonly used in traditional medicine to relieve pain in inflammatory processes. AIM OF THE STUDY:In the present study, the in vivo antinociceptive effect of Urtica circularis ethanolic extract and its isolated compounds has been investigated. MATERIALS AND METHODS:Antinociceptive activity was evaluated through writhing, formalin and hot plate tests in mice. The phytochemical analysis was performed. RESULTS:The extract produced significant inhibition on nociception induced by acetic acid (ED50: 72.2mg/kg, i.p.) and formalin (ED50: 15.8 mg/kg, i.p.) administered intraperitoneally and also orally. Atropine diminished the activity of the extract in the acetic acid test. In this model, at dose of 10mg/kg i.p., vitexin was the most active of the isolated compounds (inhibition of 91%), and chlorogenic acid, caffeic acid and vicenin-2 (6,8-di-C-glucosyl apigenin) produced an inhibition of 72%, 41% and 41%, respectively, whereas apigenin did not show any activity. CONCLUSIONS:These results suggest that Urtica circularis extract produced antinociception possibly related to the presence of vitexin, chlorogenic, caffeic acid and vicenin-2. The activation of cholinergic systems seems to be involved in the mechanism of antinociception of the extract.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Gorzalczany S,Marrassini C,Miño J,Acevedo C,Ferraro G

doi

10.1016/j.jep.2011.01.025

subject

Has Abstract

pub_date

2011-04-12 00:00:00

pages

733-8

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(11)00039-0

journal_volume

134

pub_type

杂志文章

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