Abstract:
:The effect of various doses (0, 5, 10, 20, 40 and 80 mg/kg body weight) of 50% ethanolic extract of abana, a traditional herbal preparation, widely used in India for the treatment of heart ailments, was studied on the radiation-induced mortality in mice exposed to 10 Gy of gamma-radiation. Treatment of mice with different doses of abana delayed the onset of mortality and reduced the symptoms of radiation sickness as compared to the irradiated controls. All doses of abana provided protection against the gastrointestinal (GI) death, however, the highest protection against GI death was observed for 20mg/kg abana. Pretreatment of mice with 20mg/kg abana provided the best protection as evidenced by the highest number of survivors after 30 days post-irradiation in this group when compared to the other doses of abana. Acute toxic studies revealed that the abana was non-toxic up to a dose of 1.6g/kg, where no drug-induced mortality was observed. The LD(50) dose of abana was found to be 1.8 g/kg body weight. Our study demonstrates the ability of abana as a good radioprotective agent and the optimum protective dose of abana was 1/90 of its LD(50) dose.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Jagetia GC,Baliga MS,Aruna R,Rajanikant GK,Jain Vdoi
10.1016/s0378-8741(03)00037-0keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
159-65issue
2-3eissn
0378-8741issn
1872-7573pii
S0378874103000370journal_volume
86pub_type
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
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pub_type: 杂志文章,评审
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journal_title:Journal of ethnopharmacology
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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abstract::Ethnobotanists often utilize predictive models to analyze the potential of indigenously used medicinal plants. The most common of these prognostic models is the informant consensus model. This study evaluates use of this model through the analytical ethnopharmacology of Manus Province, Papua New Guinea (PNG). The info...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2006-06-15 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2013-07-09 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2011-03-24 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2019-10-05 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2006.10.012
更新日期:2007-04-04 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,评审
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更新日期:2007-11-01 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2014-03-28 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2020-01-10 00:00:00
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journal_title:Journal of ethnopharmacology
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更新日期:2016-04-02 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2003-05-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
abstract::The present study was undertaken to evaluate the contraceptive efficacy of methanol extract of Dendrophthoe falcata Ettingsh (family-Loranthaceae), stem in male albino rats as reported in folk remedies. Adult proven fertile male rats were gavaged methanol extract of D. falcata stem at 50, 100 and 200mg/rat/day for 60 ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2007-05-30 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2006-02-20 00:00:00
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journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
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更新日期:2008-10-28 00:00:00
abstract:ETHNOPHARMACOLOGICALS RELEVANCE:Swertia corymbosa locally called as Shirattakuchi have a long history of use in Ayurveda herbal preparations in Indian traditional system of medicine. It has been used in folklore medicine for the treatment of diabetes. AIM OF THE STUDY:The present study aimed to investigate the effect ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,收录出版
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更新日期:2014-02-12 00:00:00