Abstract：
:The hypoglycaemic effect of an aqueous extract of Lepidium sativum L. (LS) seeds was investigated in normal and streptozotocin (STZ)-induced diabetic rats. After a acute (single dose) or chronic (15 daily repeated administration) oral treatments, the aqueous LS extract (20 mg/kg) produced a significant decrease on blood glucose levels in STZ diabetic rats (p < 0.001); the blood glucose levels were normalised 2 weeks after daily repeated oral administration of aqueous LS extract (20 mg/kg) (p < 0.001). Significant reduction on blood glucose levels were noticed in normal rats after both acute (p < 0.01) and chronic treatment (p < 0.001). In addition, no changes were observed in basal plasma insulin concentrations after treatment either in normal or STZ diabetic rats indicating that the underlying mechanism of this pharmacological activity seems to be independent of insulin secretion. We conclude that the aqueous extract of LS exhibits a potent hypoglycaemic activity in rats without affecting basal plasma insulin concentrations.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Eddouks M,Maghrani M,Zeggwagh NA,Michel JBdoi
10.1016/j.jep.2004.11.030keywords:
subject
Has Abstractpub_date
2005-02-28 00:00:00pages
391-5issue
2eissn
0378-8741issn
1872-7573pii
S0378-8741(04)00609-9journal_volume
97pub_type
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2010-02-17 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2014-03-28 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2018-05-10 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：1996-06-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,随机对照试验
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更新日期：2012-07-13 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2013-11-25 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2001-02-01 00:00:00
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更新日期：2021-02-10 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2002-11-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：Journal of ethnopharmacology
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abstract：AIM OF THE STUDY:The majority of people living in Kourittenga Province, Burkina Faso, are highly dependent on medicinal plants for their daily health care. Knowledge on the use of medicinal plants by traditional healers is being seriously threatened, due to the fact that it is commonly transferred from one generation t...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2011-01-27 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2008-06-19 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The African continent is home to a large number of higher plant species used over centuries for many applications, which include treating and managing diseases such as HIV. Due to the overwhelming prevalence and incidence rates of HIV, especially in sub-Saharan Africa, it is necessary to ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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更新日期：2018-01-10 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Many Thai traditional herbs have been used for hundreds of years for hair treatment and nourishment, including hair loss. However, scientific evidence about their mechanisms of action has not yet been elucidated. AIMS OF THE STUDY:The purpose of this research is to define the possible me...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2012-02-15 00:00:00
