Anti-inflammatory activity of oleoresin from Brazilian Copaifera.

Abstract:

:The oleoresin from Brazilian Copaifera species yielded copalic acid and sesquiterpenes and showed marked anti-inflammatory activity using various experimental models in rats. The oleoresin significantly inhibited carrageenin-induced pedal edema following oral doses from 0.70 to 2.69 ml/kg, but was somewhat less effective than 50 mg/kg calcium phenylbutazone. Repeated administration of the oleoresin at a dose of 1.26 ml/kg for a 6-day period reduced granuloma formation with a response comparable to that of 20 mg/kg of calcium phenylbutazone. This same dose of oleoresin also reduced the vascular permeability to intracutaneous histamine. The LD50 value of the oleoresin in rats was estimated to be 3.79 (3.21-4.47) ml/kg.

journal_name

J Ethnopharmacol

authors

Basile AC,Sertié JA,Freitas PC,Zanini AC

doi

10.1016/0378-8741(88)90235-8

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

101-9

issue

1

eissn

0378-8741

issn

1872-7573

pii

0378-8741(88)90235-8

journal_volume

22

pub_type

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