Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE:Uncaria tomentosa (Willd.) DC (Rubiaceae) is a species native to the Amazon rainforest and surrounding tropical areas that is endowed with immunomodulatory properties and widely used around the world. In this study we investigated the immunomodulatory potential of Uncaria tomentosa (UT) aqueous-ethanol extract on the progression of immune-mediated diabetes. MATERIALS AND METHODS:C57BL/6 male mice were injected with MLDS (40 mg/kg) and orally treated with UT at 10-400mg/kg during 21 days. Control groups received MLDS alone or the respective dilution vehicle. Pancreatic mononuclear infiltrate and β-cell insulin content were analyzed by HE and immunohistochemical staining, respectively, and measured by digital morphometry. Lymphocyte immunophenotyping and cytokine production were determined by flow cytometry analysis. RESULTS:Treating the animals with 50-400mg/kg of UT caused a significant reduction in the glycemic levels, as well as in the incidence of diabetes. The morphometric analysis of insulitis revealed a clear protective effect. Animals treated with UT at 400mg/kg presented a higher number of intact islets and a significant inhibition of destructive insulitis. Furthermore, a significant protection against the loss of insulin-secreting presented β-cells was achieved, as observed by a careful immunohistochemical evaluation. The phenotypic analysis indicated that the groups treated with higher doses (100-400mg/kg) presented CD4(+) and CD8(+) T-cell values similar to those observed in healthy animals. These same higher doses also increased the number of CD4(+)CD25(+)Foxp3(+) regulatory T-cells. Moreover, the extract modulated the production of Th1 and Th2, with increased levels of IL-4 and IL-5. CONCLUSIONS:The extract was effective to prevent the progression of immune-mediated diabetes by distinct pathways.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Domingues A,Sartori A,Golim MA,Valente LM,da Rosa LC,Ishikawa LL,Siani AC,Viero RMdoi
10.1016/j.jep.2011.06.021subject
Has Abstractpub_date
2011-09-01 00:00:00pages
635-42issue
1eissn
0378-8741issn
1872-7573pii
S0378-8741(11)00438-7journal_volume
137pub_type
杂志文章abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Danshen, root of Salvia miltiorrhiza (SM), has been traditionally used in Chinese medicine for the treatment of heart, abdomen, gurgling in the intestines, and relieving fullness. However, the effects of SM on intestine have rarely been done to date. AIM OF THE STUDY:To investigate the c...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2012.05.041
更新日期:2012-08-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Polygoni Multiflori Radix (PMR) and Polygoni Multiflori Radix Praeparata (PMRP) that is used after processing are two well-known traditional Chinese medicines. PMRP is traditionally reported to have lipid-reducing activity as recorded in Chinese Pharmacopoeia. AIM OF THE STUDY:This study...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.112577
更新日期:2020-04-24 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The fruit of Forsythia suspensa (Thunb.) Vahl, named Forsythiae Fructus (Lian-Qiao), is a well-known traditional Chinese medicine (TCM) used for clearing away heat and toxic material, eliminating the mass and relieving swelling. AIM OF THE STUDY:This study aims to observe the attenuation...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2018.02.033
更新日期:2018-05-23 00:00:00
abstract::In contrast to western medicine (WM), traditional Chinese medicine (TCM) does not focus on a single target but on multiple targets involved in a particular disease condition by applying diverse modalities, such as herbal medicine, acupuncture, moxibustion, etc. There is no pre-determined treatment procedure in TCM, an...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2007.12.009
更新日期:2008-03-05 00:00:00
abstract:AIM OF THE STUDY:To investigate the effect of tashinone IIA (TA) on intimal hyperplasia in a rat model of carotid artery balloon injury and on the proliferation of cultured vascular smooth muscle cells (VSMCs) induced by fetal bovine serum (FBS) and its underlying mechanisms. MATERIALS AND METHODS:Carotid artery injur...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2010.03.021
更新日期:2010-05-27 00:00:00
abstract::The vasorelaxant effect of garlic (Alium sativum L.) has been suggested to be partially mediated through endothelium. The present study was designed to evaluate the role of various endothelium-mediated mechanisms in vasorelaxant response of garlic on isolated aortic rings of rats. In tissues precontracted with phenyle...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2003.06.001
更新日期:2004-01-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:As obesity is a key factor in the development of type 2 diabetes, lowering lipid accumulation in adipose tissues is as important as increasing insulin sensitivity in diabetic patients. The selected plant extracts used in this screen have been traditionally used in Indonesian medicine for ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2015.03.082
更新日期:2015-06-20 00:00:00
abstract::The lipid lowering activity (LLA) of Phyllanthus niruri has been studied in triton and cholesterol fed hyperlipemic rats. Serum lipids were lowered by P. niruri extract orally fed (250 mg/kg b.w.) to the triton WR-1339 induced hyperlipemic rats. Chronic feeding of this drugs (100 mg/kg b.w.) in animals simultaneously ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(02)00136-8
更新日期:2002-09-01 00:00:00
abstract::The immunomodulatory effect of Ganoderma lucidum immunomodulating substance (GLIS) on macrophages has been investigated as part of on-going research into the anti-cancer properties of Ganoderma lucidum. Proliferation of bone marrow macrophages (BMMs) was enhanced by GLIS in a dose-dependent manner. Microscopic examina...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2007.03.035
更新日期:2007-07-25 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The cold/hot property of Chinese materia medica (CMM) and the application of its corresponding knowledge in the diagnosis, differentiation and treatment of diseases have been considered to be the extremely important part of traditional Chinese medicine (TCM). As highly abstracted TCM theo...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2015.12.061
更新日期:2016-02-17 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Solanum torvum (Solanaceae) is a plant currently used in Cameroon ethnomedicine for the treatment of stomach ailments. AIM OF THE STUDY:The present study was undertaken to determine the anti-ulcer potential of the aqueous and methanol extracts from the leaves of Solanum torvum. MATERIAL...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2008.06.008
更新日期:2008-09-02 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Genkwa flos, as a traditional herb, is the dried flower buds of Daphne genkwa Sieb.et Zucc. It is used in traditional medicine for the treatment of cough, sore throats, edema. AIM OF THE STUDY:The study aimed to explore a new mathematical method for multivariate evaluation, investigate t...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.113683
更新日期:2021-03-25 00:00:00
abstract::This article examines data presented in Katz' book, Boiling Energy: Community Healing among the Kalahari Kung, particularly with regard to plant drugs present in the community during the 1968 visit. The author argues that the similarity of the Bushman trance state, kia and that of drug-induced altered states of consci...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(86)90168-6
更新日期:1986-03-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The modified-Chungsimyeolda-tang (DG) is an important traditional Korean herbal formula used in traditional oriental medicine for treatment of cerebrovascular disorders, including stroke. The formula is based on the book "Dongui Sasang Shinpyun". AIM OF THE STUDY:In the previous studies,...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2015.11.013
更新日期:2015-12-24 00:00:00
abstract::Extraction of the roots of the Amazonian medicinal plant, Piper piscatorum Trelease and Yuncker, with MeOH and subsequent bioassay guided fractionation using the guppy, Girardina guppii yielded the active amide, N-isobutyl-6-(p-methoxyphenyl) 2E, 4E-hexadieneamide (piperovatine) and a second inactive amide, N-isobutyl...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(97)00154-2
更新日期:1998-03-01 00:00:00
abstract:AIM OF THE STUDY:We examined the effects of the aqueous fraction (AF) on nociception models mice induced by the chemical and the thermal stimuli so as to elucidate the analgesic activity and provide scientific basis for the clinical use of Paederia scandens. MATERIALS AND METHODS:The AF of MeOH extract from P. scanden...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2008.03.011
更新日期:2008-06-19 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Wan-Sheng-Hua-Feng-Dan (WSHFD) is a traditional Chinese medicine used for the treatment of neurological disorders. Cinnabar (HgS) and realgar (As(4)S(4)) are included in WSHFD. Are they remedies or poisons? AIM OF STUDY:To investigate the role of cinnabar and realgar in the protective ef...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2011.12.026
更新日期:2012-02-15 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Modified Si-Miao-San (mSMS) is a prescription modified from Si-Miao-San which is an ancient Chinese prescription used to treat various ailments. AIM OF THE STUDY:Modified Si-Miao-San (mSMS) has been used for the treatment of infectious and inflammatory disorders in the clinic. This study...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2010.02.002
更新日期:2010-05-04 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Senescent leaves of Heliotropium foertherianum Diane & Hilger (Boraginaceae) are traditionally used in the Pacific region to treat Ciguatera Fish Poisoning. This plant contains rosmarinic acid that is known for its multiple biological activities. In the present study, H. foertherianum aqu...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2012.05.045
更新日期:2012-08-30 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Hyangaa-Pyeongwi san is the most well known description in Traditional Chinese Medicine for treating functional gastrointestinal disorders. Functional dyspepsia (FD) is a main concern of intimidating quality of life (QoL) in recent days. Although many medicines have been developed to impr...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jep.2013.10.033
更新日期:2014-01-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable. MATERIALS AND METHODS:In the present study, the antidepressant-like effects of P...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2017.01.037
更新日期:2017-03-06 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Synadenium grantii Hook f. has traditionally been used to treat various neoplastic diseases in southern Brazil. AIM OF STUDY:Evaluation of the antitumoural potential of Synadenium grantii latex against B16F10 melanoma cell line using in vitro and in vivo models, as well as a phytochemica...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2013.08.033
更新日期:2013-10-28 00:00:00
abstract::Mangifera indica is commonly grown in many parts of the world. Its seeds have been used for anti-diarrhoeal activity in Indian traditional medicine. This study evaluates the potential anti-diarrhoeal activity of methanolic (MMI) and aqueous (AMI) extracts of seeds of M. indica in experimental diarrhoea, induced by cas...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/s0378-8741(02)00250-7
更新日期:2003-01-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Cedrus deodara (Roxb. ex D.Don) G. Don is applied as anti-inflammatory and anti-infection agents in folklore medicine. AIM OF THE STUDY:The present study aimed to assess the antimicrobial activity of Cedrus deodara (Roxb. ex D.Don) G. Don extract (CDE) against Streptococcus mutans biofil...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2020.112856
更新日期:2020-07-15 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Withania somnifera (WS) root extract has been used traditionally in ayurvedic system of medicine as a memory enhancer and anti-stress agent. AIM OF THE STUDY:To evaluate the neuroprotective and prophylactic potential of WS root extract in ameliorating hypobaric hypoxia (HH) induced memor...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2012.10.063
更新日期:2013-01-30 00:00:00
abstract::It has been reported that heme oxygenase-1 (HO-1) mediates the anti-inflammatory activity of the n-BuOH subfraction (PL) prepared from fruiting bodies of Phellinus linteus. This continuing work aimed to elucidate the signaling pathway to the up-regulation of HO-1 by PL. In RAW264.7 macrophage cells, PL was able to enh...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2007.05.032
更新日期:2007-09-05 00:00:00
abstract::Recent research suggests that, in addition to the well-documented occurrence of significant quantities of cocaine and related alkaloids in a limited number of species, the genus Erythroxylon will prove to be a rich source of tropane alkaloids. These bases are esters of a range of acids with tropine, 3 alpha, 6 beta-di...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(81)90057-x
更新日期:1981-03-01 00:00:00
abstract::Twelve pure compounds originally obtained through a systematic chemotaxonomical study with Mexican plants of the Asteraceae, were subjected to a cytotoxic and in vitro antimicrobial screening. Three different cell lines in culture (KB, KB-VI and P388) were used in the cytotoxicity assay, while antimicrobial activity w...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/0378-8741(94)90019-1
更新日期:1994-03-01 00:00:00
abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Pistachio hull has traditionally been used to treat peptic ulcer, hemorrhoids, oral and cutaneous wounds. AIM OF THE STUDY:On the basis of its traditional uses and previous pharmacological reports, a bioassay guided fractionation procedures on pistachio (Pistacia vera L.) hulls was perfo...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2019.112335
更新日期:2020-02-10 00:00:00
abstract::Several plants are traditionally used to treat mental diseases in South Africa. Forty-six ethanol extracts from 35 species, both indigenous and exotic that are traditionally used predominantly as sedatives or to treat various CNS-related ailments were tested in the GABAA-benzodiazepine receptor-binding assay. In this ...
journal_title:Journal of ethnopharmacology
pub_type: 杂志文章
doi:10.1016/j.jep.2005.04.004
更新日期:2005-08-22 00:00:00