当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: a phytochemical and pharmacological review.

Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: a phytochemical and pharmacological review.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:For nearly 2000 years Sargassum spp., a brown seaweed, has been used in Traditional Chinese Medicine (TCM) to treat a variety of diseases including thyroid disease (e.g. goitre). AIMS OF THE REVIEW:To assess the scientific evidence for therapeutic claims made for Sargassum spp. in TCM and to identify future research needs. BACKGROUND AND METHODS:A systematic search for the use of Sargassum in classical TCM books was conducted and linked to a search for modern phytochemical and pharmacological data on Sargassum spp. retrieved from PubMed, Web of Knowledge, SciFinder Scholar and CNKI (in Chinese). RESULTS AND DISCUSSION:The therapeutic effects of Sargassum spp. are scientifically plausible and may be explained partially by key in vivo and in vitro pharmacological activities of Sargassum, such as anticancer, anti-inflammatory, antibacterial and antiviral activities. Although the mechanism of actions is still not clear, the pharmacological activities could be mainly attributed to the major biologically active metabolites, meroterpenoids, phlorotanins and fucoidans. The contribution of iodine in Sargassum for treating thyroid related diseases seem to have been over estimated. CONCLUSIONS:The bioactive compounds in Sargassum spp. appear to play a role as immunomodulators and could be useful in the treatment of thyroid related diseases such as Hashimoto's thyroiditis. Further research is required to determine both the preventative and therapeutic role of Sargassum spp. in thyroid health.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Liu L,Heinrich M,Myers S,Dworjanyn SA

doi

10.1016/j.jep.2012.05.046

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

591-619

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(12)00368-6

journal_volume

142

pub_type

杂志文章,评审

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