Abstract：
:Bioassay-guided fractionation of the rhizomes of Astilbe chinensis afforded four cytotoxic pentacyclic triterpenoids, 3beta-hydroxy-olean-12-en-27-oic acid (1), 3beta,6beta-dihydroxy-olean-12-en-27-oic acid (2), 3beta-acetoxy-olean-12-en-27-oic acid (3), and 3beta-hydroxy-urs-12-en-27-oic acid (4). The isolation and purification of these compounds was conducted with the application of column chromatography. Their structures were elucidated on the basis of chemical and spectral evidence. 2D NMR techniques including 1H-1H COSY, HMQC, HMBC spectra and HREIMS were extensively applied to establish the structures. Compounds 1-4 showed cytotoxic activities against HO-8910, Hela and HL60 in vitro; moreover, compound 1 induced apoptotic cell death of the HO-8910 in a dose-dependent manner, ranging from 2.5 to 40.0 microg/ml. The presence of these active compounds may be responsible, at least in part, for the antineoplastic action of the traditional crude drug Rhizoma Astilbe chinensis.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Sun HX,Ye YP,Pan YJdoi
10.1016/j.jep.2003.10.003keywords:
subject
Has Abstractpub_date
2004-02-01 00:00:00pages
261-5issue
2-3eissn
0378-8741issn
1872-7573pii
S0378874103003702journal_volume
90pub_type
杂志文章abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The antiulcer potentials of most plants still remain largely unexplored, despite their prospects evidenced by their use as ethnomedicine. Entada africana (Mimosaceae) has been widely used in Africa for the treatment of skin infections, wounds, tonic for stomach troubles and against diphth...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.06.012
更新日期：2011-09-01 00:00:00
abstract：:Many cardiovascular diseases are associated with an increase in blood platelet activity. In Morocco, parsley (Petroselinum crispum, Apiaceae) is one of the medicinal herbs used to treat cardiovascular diseases such as arterial hypertension. In this study, crude aqueous extract (CAE) of parsley was evaluated for its an...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.05.014
更新日期：2009-08-17 00:00:00
abstract：:The investigation into the effects of Ginkgo biloba extracts on tinnitus has suffered from a dearth of effective animal models as well as systematic clinical trials employing double-blind and placebo-controlled designs. Some clinical trials have yielded positive results, however, these studies are few and have been li...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2005.05.032
更新日期：2005-08-22 00:00:00
abstract：:A total of seventeen phytochemicals including seven alkaloids (piperine, strychnine, brucine, stachydrine, tetrandrine, frangchinoline and sinomenine), four phenols (paeonol, honokiol, magnolol and eugenol) and six anthraquinones (emodin, rhein, chrysorphanol, aloe-emodin, physcion and 1,8-dihydroxyanthraquinone) was ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2004.01.013
更新日期：2004-04-01 00:00:00
abstract：AIM OF THE STUDY:Depression is a severe mood disorder. It was treated with Shudihuang, the steamed roots of Rehmannia glutinota Libosch. (SRG), in traditional Chinese medicine. The present paper was designed to verify its antidepressant effect. MATERIALS AND METHODS:A mouse model of depression was established though u...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.02.029
更新日期：2009-05-04 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Traditional Chinese herbal medicine (CHM) has a long-history for treatment of various human diseases including tumors, infection, autoimmune diseases in Asian countries, especially in China, Japan, Korea and India. CHM was traditionally used as water extracts and many Chinese herbs were c...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2015.05.050
更新日期：2015-08-02 00:00:00
abstract：:This in vitro study aimed at determining the effects of various sublethal concentrations of Streblus asper leaf ethanolic extract (SAE) on adherence of Candida albicans to acrylic surface. A colorimetric tetrazolium assay using (2,3)-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)-carbonyl]-2H-tetrazolium hydro...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2006.01.021
更新日期：2006-07-19 00:00:00
abstract：:Guaraná is considered an ideal crop for supplementing the incomes of small peasant farmers in the Amazon basin. A fast-growing perennial, guaraná can be planted in the midst of manioc crops, allowing the formation of extensive orchards in the place of regenerating scrub once the manioc has been harvested. Traditional ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(82)90054-x
更新日期：1982-11-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Flourensia fiebrigii is a plant used in traditional medicine in the Argentine Calchaquí Valley as purgative, expectorant, anti-rheumatic and anti-inflammatory. AIM OF THE STUDY:The aim of this study was to analyze the macroscopic and microscopic characteristics of F. fiebrigii leaf and s...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113296
更新日期：2021-01-10 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:In Colombia, the only authorized treatment to cure snakebite envenomation is with the use of antivenom. The antivenom neutralizes the systemic effects properly, but is not very effective at neutralizing local effects, thus several cases have lead to complications. On the other hand, rural...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2019.112046
更新日期：2019-10-05 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Taraxacum officinale (L.), commonly called dandelion has been used for centuries as a natural medicine to treat inflammatory diseases including some metabolic alterations associated with obesity. AIM OF THE STUDY:Based on animal experiments this study aims to explore the potential mechan...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113393
更新日期：2021-01-30 00:00:00
abstract：:Murdannia bracteata has been used as a Taiwanese folk medicine for its anti-inflammatory properties. However, neither its active ingredients nor its anti-inflammatory actions are well defined. Nitric oxide (NO), overproduced by activated macrophages via inducible NO synthase (iNOS), is suggested to be a significant pa...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2007.02.025
更新日期：2007-06-13 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Sambucus ebulus L. (S. ebulus) has had long-standing application in Traditional Persian Medicine for joint pain and for a variety of bone and joint disorders. According to traditional use of S. ebulus and its relevant pharmacologic properties, this study was designed to evaluate the effic...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jep.2016.04.035
更新日期：2016-07-21 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Maimendong and Qianjinweijing Tang (Jin formula), a classic Chinese formula, can enhance therapeutic efficacy and reduce adverse effects in patients with lung cancer. AIM OF THE STUDY:To evaluate the anti-lung cancer effect of Jin formula in vivo and in vitro, and to explore the role of ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112836
更新日期：2020-08-10 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Caesalpinia sappan is a medicinal plant native to China popularly used to treat chronic pelvic inflammation, dysmenorrhea and hysteromyoma. Its main bioactive component is brazilin which had presented antibacterial, anti-inflammatory and anti-platelet aggregation activities. To establish ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2013.08.054
更新日期：2014-01-01 00:00:00
abstract：:The Indians of the northwest Amazon respect age and try to care for those suffering from senile dementia. At least 25 species of plants are employed in treating Alzheimer's disease or similar problems. The plants are administered orally as teas of the leaves or roots and over a period of several days to numerous weeks...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/0378-8741(93)90007-r
更新日期：1993-03-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Withania somnifera root extract (Ws)/Ashwagandha/Indian ginseng is a traditional herbal medicine, used over 4000 years in India, shown to have effect on neural growth and locomotor function. Although catecholamines and oxidative stress resulting in neurodegeneration and locomotor disorder...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.08.003
更新日期：2009-09-25 00:00:00
abstract：:Keishi-bukuryo-gan (TJ-25) is a traditional Chinese herbal remedy containing five components: bark of Cinnamomum cassia, root of Paeonia lactiflora, seed of Prunus persica or P. persiba var. davidiana, carpophores of Poria cocos and root bark of Paeonia suffruticosa. This preparation has been used in the treatment of ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/0378-8741(88)90002-5
更新日期：1988-07-01 00:00:00
abstract：AIM:To validate plant species for hypoglycaemic activity. MATERIALS AND METHODS:Four plants were investigated for hypoglycaemic activity by evaluating inhibiting effects on carbohydrate-hydrolising enzymes: alpha-glucosidase and alpha-amylase. Acetone plant extracts were screened against C2C12 myocytes, 3T3-L1 preadip...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.04.052
更新日期：2009-07-30 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.02.024
更新日期：2017-03-22 00:00:00
abstract：ETHNOPHARMACOLOGIC RELEVANCE:Lavandula angustifolia Mill (lavender) odor was traditionally used as sleep enhancer. Previous studies have shown interaction between insomnia, quality of life and control of diabetes mellitus (DM). Insomnia is suggested to increase the risk of depression and decrease the quality of life in...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.112560
更新日期：2020-04-06 00:00:00
abstract：AIM OF THE STUDY:The present study was undertaken to evaluate the wound healing effects of the four chief saponins of Astragalus species [cycloastragenol (CA), astragaloside IV (AG), cyclocephaloside I (CCI) and cyclocanthoside E (CCE)]. MATERIAL AND METHODS:Effects of cell viability and proliferation of the isolated ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2011.01.030
更新日期：2011-04-12 00:00:00
abstract：:Studies on ethnomedicobotany of Kandha tribe of Orissa, India, are scanty. In view of this the original ethno-botanical information and plant specimens were collected from the Kandhamal district of Orissa by visiting the area several times. The paper reports 27 plant species belonging to 24 families used in the treatm...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2005.06.024
更新日期：2005-12-01 00:00:00
abstract：:Since its role in inflammatory diseases was recognized, nitric oxide (NO) has become an important mediator to evaluate anti-inflammatory agents. Sesquiterpene lactones, which occur in several medicinal plants, inhibit the NO production in macrophage-like cells. This action is probably due to a 1,4 addition reaction be...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2004.07.020
更新日期：2004-12-01 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Berberine is generally extracted from Rhizoma Coptidis (Coptis chinensis Franch), a traditional Chinese medicine, which can be used in the treatment of intestinal diseases, respiratory infections and cardiovascular diseases. Berberine is especially effective for the treatment of gastroint...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2020.113206
更新日期：2021-01-10 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Chyawanprash (CP), a traditional immune booster recipe, has a long history of ethnic origin, development, household preparation and usage. There are even mythological stories about the origin of this recipe including its nomenclature. In the last six decades, CP, because of entrepreneuria...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2016.07.078
更新日期：2017-02-02 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Cynanchi atrati Radix has been traditionally prescribed for patients with inflammatory fever or chronic tumoral disorders. Melanoma is one of the most devastating cancer types, in which overexpression of nuclear factor kappa B (NF-κB) enables the cancer to survive without apoptosis. To id...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2014.02.037
更新日期：2014-04-11 00:00:00
abstract：:The present study was aimed to investigate antimicrobial potential of Glycyrrhiza glabra roots. Antimycobacterial activity of Glycyrrhiza glabra was found at 500 microg/mL concentration. Bioactivity guided phytochemical analysis identified glabridin as potentially active against both Mycobacterium tuberculosis H(37)Ra...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2007.11.037
更新日期：2008-03-05 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The root of Peucedanum japonicum Thunberg is traditionally used to treat coughs, colds, headache and inflammatory diseases in Korea and Japan. Its effects on allergic lung inflammation have not been investigated. AIM OF THE STUDY:To investigate the anti-asthmatic effects of Peucedanum ja...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2017.09.006
更新日期：2018-01-30 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Ammannia baccifera L. has been reported as folklore remedy for the treatment of inflammation and tumor in the state of Rajasthan, India. AIM OF THE STUDY:The present study was designed to investigate the antioxidant, anti-inflammatory and anti-nociceptive effects of the methanol extract ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2012.01.001
更新日期：2012-03-27 00:00:00
