当前位置： SCI文献检索 > JOURNAL OF ETHNOPHARMACOLOGY期刊下所有文献 > Antioxidant, anti-inflammatory and anti-nociceptive effects of Ammannia baccifera L. (Lythracceae), a folklore medicinal plant.

Antioxidant, anti-inflammatory and anti-nociceptive effects of Ammannia baccifera L. (Lythracceae), a folklore medicinal plant.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Ammannia baccifera L. has been reported as folklore remedy for the treatment of inflammation and tumor in the state of Rajasthan, India. AIM OF THE STUDY:The present study was designed to investigate the antioxidant, anti-inflammatory and anti-nociceptive effects of the methanol extract from the aerial parts of Ammannia baccifera under in vitro and in vivo models. MATERIALS AND METHODS:The in vitro antioxidant activity of the extract was measured using DPPH, superoxide, hydroxyl and nitric oxide radicals. The anti-inflammatory activity was evaluated using carrageenan induced paw edema. Analgesic activity of the methanol extract was estimated against acetic acid-induced writhing and hot plate methods. RESULTS:The IC(50) value for free radical scavenging activity of this extract was significantly superior over the positive standards butylated hydroxyl anisole (BHA) and rutin. The extract exhibited significant anti-inflammatory and analgesic activities at the dose of 100 and 200mg/kg p.o. The analgesic effect of the higher dose of the extract (200mg/kg) was comparable with the standard drugs aspirin and morphine. CONCLUSION:The present study scientifically validated the traditional use of this plant against inflammation.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Loganayaki N,Siddhuraju P,Manian S

doi

10.1016/j.jep.2012.01.001

subject

Has Abstract

pub_date

2012-03-27 00:00:00

pages

230-3

issue

2

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(12)00002-5

journal_volume

140

pub_type

杂志文章

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