Anti-inflammatory activity and gastroprotective effect of Hertia cheirifolia L. roots extract.

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE:Hertia cheirifolia L. is used traditionally to treat rheumatic pains and known as a medicinal plant having several pharmaceutical and biological activities. The present study evaluated in vivo the anti-inflammatory and gastroprotective effects of the methanolic extract from H. cheirifolia L. MATERIALS AND METHODS:Reverse phase high-performance liquid chromatography (RP-HPLC) was performed to identify various chemical components of the plant extract. Anti-inflammatory and gastroprotective activities were assessed on carrageenan-induced paw edema and HCl/ethanol-induced gastric lesions in rats, respectively. RESULTS:(RP-HPLC) analysis indicated that coumarin is the abundant component in the extract (53.80%). Intraperitoneal administration of the methanolic extract at different doses showed interesting activities in rats in a dose-dependent manner. At 100 mg/kg, this extract showed the highest acute anti-inflammatory activity and an important inhibition of gastric lesions with inhibition percentage of 79.41% and 88.53%, respectively. CONCLUSION:Altogether, the results of this study reveal the anti-inflammatory and gastroprotective effects of H. cheirifolia extract and promote the traditional use of this plant in the treatment of different pain and inflammatory diseases.

journal_name

J Ethnopharmacol

authors

Majouli K,Hamdi A,Abdelhamid A,Bouraoui A,Kenani A

doi

10.1016/j.jep.2018.02.010

subject

Has Abstract

pub_date

2018-05-10 00:00:00

pages

7-10

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(17)33151-3

journal_volume

217

pub_type

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