Effect of saponins from Helicteres isora on lipid and glucose metabolism regulating genes expression.

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE:We characterized saponins as active constituents from traditionally used antidiabetic plant Helicteres isora. AIM OF THE STUDY:To evaluate the changes in the gene expression of the glucose and lipid metabolism regulating genes in C57BL/KsJ-db/db mice. MATERIALS AND METHODS:C57BL/KsJ-db/db mice were divided into four different groups; one diabetic control, the mice in other three groups were treated with methanol extract (100 mg/kg), saponins (100 mg/kg) and pioglitazone (30 mg/kg) for 14 days. After completion of the treatment period biochemical parameters and the expression levels of adipsin, adiponectin, glucose transporter 4 (Glut4), peroxisome proliferator activated receptor gamma (PPARgamma), fatty acid binding protein 4 (FABP4), lipoprotein lipase (LPL) in adipose tissue and for liver RNA samples glucose-6-phosphatase (G6Pase), phosphoenolpyruvate carboxykinase (PEPCK), glucose transporter 2 (Glut2) and acyl-co-enzyme A oxidase (ACOX) were determined by quantitative real time PCR and angiopoeitin like 3 (ANGPTL3), angiopoeitin like 4 (ANGPTL4) and peroxisome proliferator activated receptor alpha (PPARalpha) by semiquantitative reverse transcription PCR. RESULTS:Treatment caused a significant reduction in the serum lipid and glucose levels and increased the expression of adipsin, PPARgamma and Glut4 while reduced expression of FABP4 and G6Pase, whereas there was no effect on the expression levels of adiponectin, LPL, PEPCK, ACOX, Glut2, ANGPTL3, ANGPTL4 and PPARalpha. CONCLUSIONS:Saponins are beneficial for improving hyperlipidemia and hyperglycemia by increasing the gene expression of adipsin, Glut4 and PPARgamma and reducing the gene expression of the enzyme G6Pase and FABP4 in C57BL/KsJ-db/db mice.

journal_name

J Ethnopharmacol

authors

Bhavsar SK,Singh S,Giri S,Jain MR,Santani DD

doi

10.1016/j.jep.2009.05.041

subject

Has Abstract

pub_date

2009-07-30 00:00:00

pages

426-33

issue

3

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(09)00333-X

journal_volume

124

pub_type

杂志文章
  • Anti-inflammatory activity of the bark of Hippocratea excelsa.

    abstract::The ethanol extract of the plant Hippocratea excelsa was examined for its anti-inflammatory effects using several animal models. It produced significant inhibition of carrageenan-induced paw edema and reduced the weight of cotton pellet-induced granuloma at doses of 25-100 mg/kg. The extract was found to exert a prote...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(95)01257-e

    authors: Perez RM,Perez S,Zavala MA,Salazar M

    更新日期:1995-07-07 00:00:00

  • In search of the perfect aphrodisiac: parallel use of bitter tonics in West Africa and the Caribbean.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Enslaved Africans in the Americas had to reinvent their medicinal flora in an unknown environment by adhering to plants that came with them, learning from Amerindians and Europeans, using their Old World knowledge and trial and error to find substitutes for their homeland herbs. This proc...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2012.08.008

    authors: van Andel T,Mitchell S,Volpato G,Vandebroek I,Swier J,Ruysschaert S,Rentería Jiménez CA,Raes N

    更新日期:2012-10-11 00:00:00

  • Cytotoxic oleanane triterpenoids from the rhizomes of Astilbe chinensis (Maxim.) Franch. et Savat.

    abstract::Bioassay-guided fractionation of the rhizomes of Astilbe chinensis afforded four cytotoxic pentacyclic triterpenoids, 3beta-hydroxy-olean-12-en-27-oic acid (1), 3beta,6beta-dihydroxy-olean-12-en-27-oic acid (2), 3beta-acetoxy-olean-12-en-27-oic acid (3), and 3beta-hydroxy-urs-12-en-27-oic acid (4). The isolation and p...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2003.10.003

    authors: Sun HX,Ye YP,Pan YJ

    更新日期:2004-02-01 00:00:00

  • Toxicity and potential anti-trypanosomal activity of ethanolic extract of Azadirachta indica (Maliacea) stem bark: an in vivo and in vitro approach using Trypanosoma brucei.

    abstract:AIM OF THE STUDY:To determine the toxicity and anti-trypanosomal activity of the ethanolic extract of Azadirachta indica (Maliacea) stem bark, through in vivo and in vitro approach using Trypanosoma brucei brucei. MATERIALS AND METHODS:Graded concentrations (100, 200, 400, 800, 1600 and 3200 mg/kg) of the crude stem b...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.01.013

    authors: Mbaya AW,Ibrahim UI,God OT,Ladi S

    更新日期:2010-03-24 00:00:00

  • Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The blister beetle, also known as Mylabris cichorii, is not only widely used in clinical applications in Chinese anticancer medicine, but is also one of the main ingredients in a variety of traditional Chinese medicinal preparations with anticancer activity. However, the strong toxicity e...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2016.03.058

    authors: Yu M,Zhao Y

    更新日期:2016-06-20 00:00:00

  • Triterpenoid saponins from Ilex cornuta protect H9c2 cardiomyocytes against H2O2-induced apoptosis by modulating Ezh2 phosphorylation.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ilex cornuta Lindl. et Paxt. (Aquifoliaceae family) belongs to the Ilex genus. The leaves of this plant are used for the popular herbal tea "Ku-Ding-Cha" in China due to their health benefits for sore throat, obesity and hypertension. Our previous studies have shown that the extract of Il...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113691

    authors: Yu D,Zhu Z,Wang M,Ding X,Gui H,Ma J,Yan Y,Li G,Xu Q,Wang W,Mao C

    更新日期:2021-04-06 00:00:00

  • Syzygium cumini (L.) Skeels essential oil and its major constituent α-pinene exhibit anti-Leishmania activity through immunomodulation in vitro.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as "jambolão" in Brazil is widely used in folk medicine against leishmaniasis, inflammation, chronic diarrhea, and ulcers. It is one of the most commonly used plants for the treatment of diabetes worldwide. In previous studies, Syzyg...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2014.11.024

    authors: Rodrigues KA,Amorim LV,Dias CN,Moraes DF,Carneiro SM,Carvalho FA

    更新日期:2015-02-03 00:00:00

  • Anti-cancer effects of ethanol extract of Reynoutria japonica Houtt. radix in human hepatocellular carcinoma cells via inhibition of MAPK and PI3K/Akt signaling pathways.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Reynoutria japonica Houtt. has been used as a traditional medicine of cancer in East Asia for thousands of years. However, the mechanism of the anti-cancer effect of R. japonica has not been investigated at the molecular level. The regulation of intracellular signaling pathways by the ext...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112179

    authors: Kim BR,Ha J,Lee S,Park J,Cho S

    更新日期:2019-12-05 00:00:00

  • A review on the elemental contents of Pakistani medicinal plants: Implications for folk medicines.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Substantially, plants produce chemicals such as primary and secondary metabolites, which have significant applications in modern therapy. Indigenous people mostly rely on traditional medicines derived from medicinal plants. These plants have the capacity to absorb a variety of toxic eleme...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2016.05.011

    authors: Aziz MA,Adnan M,Begum S,Azizullah A,Nazir R,Iram S

    更新日期:2016-07-21 00:00:00

  • Selective inducible nitric oxide synthase suppression by new bracteanolides from Murdannia bracteata.

    abstract::Murdannia bracteata has been used as a Taiwanese folk medicine for its anti-inflammatory properties. However, neither its active ingredients nor its anti-inflammatory actions are well defined. Nitric oxide (NO), overproduced by activated macrophages via inducible NO synthase (iNOS), is suggested to be a significant pa...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2007.02.025

    authors: Wang GJ,Chen SM,Chen WC,Chang YM,Lee TH

    更新日期:2007-06-13 00:00:00

  • Cyperus rotundus L.: Traditional uses, phytochemistry, and pharmacological activities.

    abstract:ETHNO-PHARMACOLOGICAL RELEVANCE:Cyperus rotundus L. (Cyperaceae) is a medicinal herb traditionally used to treat various clinical conditions at home such as diarrhea, diabetes, pyresis, inflammation, malaria, and stomach and bowel disorders. Currently, it is one of the most widespread, problematic, and economically dam...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2015.08.012

    authors: Pirzada AM,Ali HH,Naeem M,Latif M,Bukhari AH,Tanveer A

    更新日期:2015-11-04 00:00:00

  • Antihepatotoxic actions of gingerols and diarylheptanoids.

    abstract::The antihepatotoxic effects of gingerols, shogaols, diarylheptanoids and related analogues were assessed utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most congeners exhibited significant actions in these assay methods. The carbon tetrachloride assay appear...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(85)90025-x

    authors: Hikino H,Kiso Y,Kato N,Hamada Y,Shioiri T,Aiyama R,Itokawa H,Kiuchi F,Sankawa U

    更新日期:1985-09-01 00:00:00

  • Paeonia lactiflora extract suppresses cisplatin-induced muscle wasting via downregulation of muscle-specific ubiquitin E3 ligases, NF-κB signaling, and cytokine levels.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The dried root of Paeonia lactiflora Pall. (Radix Paeoniae) has been traditionally used to treat various inflammatory diseases in many Asian countries. AIM OF THE STUDY:Cisplatin is a broad-spectrum anticancer drug used in diverse types of cancer. However, muscle wasting is a common side...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113403

    authors: Jang J,Lee H,Song J,Bae T,Park M,Kwon YV,Lee D,Yoon Y

    更新日期:2021-02-10 00:00:00

  • Toxicological safety evaluation in acute and 28-day studies of aqueous extract from Bei-Qi-Wu-Jia formula.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Bei Qi Wu Jia (BQWJ), a modern preparation of a traditional Chinese medicinal formula, is a combination of Radix Astragali and Acanthopanacis Senticosi. Although BQWJ has been used to treat insomnia, fatigue, and loss of appetite, toxicological safety studies are rare in the literature. ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112324

    authors: Zhao L,Li P,Xu H,Han B,Chen J,Gao Z,Li J,Li X,Wu C

    更新日期:2020-02-10 00:00:00

  • Chemopreventive activity of Ocimum sanctum seed oil.

    abstract::The seed oil of Ocimum sanctum was evaluated for chemopreventive activity against subcutaneously injected 20-methylcholanthrene induced-fibrosarcoma tumors in the thigh region of Swiss albino mice. Supplementation of maximal tolerated dose (100 microl/kg body weight) of the oil significantly reduced 20-methylcholanthr...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(00)00194-x

    authors: Prakash J,Gupta SK

    更新日期:2000-09-01 00:00:00

  • Medicinal plants of the Meinit ethnic group of Ethiopia: an ethnobotanical study.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The majority of the Ethiopian people, including the Meinit ethnic group, are highly dependent on medicinal plants for their day-to-day public healthcare and veterinary needs. The existence of medicinal plants and the associated knowledge is, however, currently being threatened mainly due ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2009.05.009

    authors: Giday M,Asfaw Z,Woldu Z

    更新日期:2009-07-30 00:00:00

  • Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Persicae Semen (Taoren) and Carthami Flos (Honghua) used in pair which is named as Taoren-Honghua (TH) herb pair has been used in traditional Chinese medicine (TCM) for promoting blood circulation to dissipate blood stasis for many years in China. AIM OF THE STUDY:This paper investigated...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.11.016

    authors: Liu L,Duan JA,Tang Y,Guo J,Yang N,Ma H,Shi X

    更新日期:2012-01-31 00:00:00

  • Src and Syk are targeted to an anti-inflammatory ethanol extract of Aralia continentalis.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Aralia continentalis Kitagawa (Araliaceae) is a representative ethnomedicinal herbal plant traditionally prescribed in Korea to relieve various inflammatory symptoms. However, the exact molecular mechanism of its anti-inflammatory activity has not been fully investigated. MATERIALS AND M...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2012.07.031

    authors: Jeong HY,Moh SH,Yang Y,Yu T,Oh J,Jeong D,Yoon DH,Park KM,Lee S,Kim TW,Hong S,Kim SY,Cho JY

    更新日期:2012-09-28 00:00:00

  • Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The rhizomes of Kaempferia parviflora Wall. ex Baker have been traditionally used in Thailand to treat abscesses, gout, and peptic ulcers. AIM:Previously, we reported that the chloroform fraction of a Kaempferia parviflora extract had an inhibitory effect on rat paw-edema. In the present...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.01.013

    authors: Sae-Wong C,Matsuda H,Tewtrakul S,Tansakul P,Nakamura S,Nomura Y,Yoshikawa M

    更新日期:2011-07-14 00:00:00

  • In vitro cytotoxicity and immunomodulating property of Rhaphidophora korthalsii.

    abstract::An in vitro cytotoxic screening of extracts of Rhaphidophora korthalsii indicated cytotoxicity in the ether fraction. ED50 values of the extract against P388, Molt 4, KB and SW 620 were 12, 14, 8 and 13 micrograms/ml, respectively. The extract was relatively more toxic on P388 and Molt 4 cell lines at concentrations o...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(96)01391-8

    authors: Wong KT,Tan BK

    更新日期:1996-05-01 00:00:00

  • Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells.

    abstract:AIM OF THE STUDY:Salvianolic-acid B (SA-B) is an effective component of Radix Salviae miltiorrhizae for anti-hepatic fibrotic herbs. MAPK signaling pathway has been implicated in hepatic stellate cells (HSC) stimulated by TGF-(1. We have investigated the effect of SA-B on MAPK pathway in rat HSC. MATERIALS AND METHODS...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.05.026

    authors: Lv Z,Song Y,Xue D,Zhang W,Cheng Y,Xu L

    更新日期:2010-11-11 00:00:00

  • Possible involvement of GABA A-benzodiazepine receptor in the anxiolytic-like effect induced by Passiflora actinia extracts in mice.

    abstract::Hydroethanol (HE) and methanol (ME) extracts obtained from the leaves of Passiflora actinia Hooker were evaluated for behavioral effects in mice. Single-dose oral administration of HE (300 and 600 mg/kg) or ME (100 and 300 mg/kg) resulted in anxiolytic-like effects in the elevated plus-maze. The anxiolytic-like effect...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.11.021

    authors: Lolli LF,Sato CM,Romanini CV,Villas-Boas Lde B,Santos CA,de Oliveira RM

    更新日期:2007-05-04 00:00:00

  • Antiallergic effects of Scutellaria baicalensis on inflammation in vivo and in vitro.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Scutellaria baicalensis (SB) is one of the most widely used medicinal herbs for the treatment of inflammation. In this study, we investigated the antiallergic effect of SB in vivo and in vitro. MATERIALS AND METHODS:Sprague-Dawley (SD) rats received intradermal injections of anti-DNP IgE...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2012.02.044

    authors: Jung HS,Kim MH,Gwak NG,Im YS,Lee KY,Sohn Y,Choi H,Yang WM

    更新日期:2012-05-07 00:00:00

  • Antibacterial activity of medicinal plants from The Physicians of Myddvai, a 14th century Welsh medical manuscript.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Antimicrobial drug resistance is a growing threat to global public health. Historical records and herbal texts relating to traditional Celtic medicine indicate an extensive pharmacopeia of plants for treating infections likely caused by microbes. However, a major barrier for successful in...

    journal_title:Journal of ethnopharmacology

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.jep.2017.03.039

    authors: Wagner CS,De Gezelle J,Robertson M,Robertson K,Wilson M,Komarnytsky S

    更新日期:2017-05-05 00:00:00

  • The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Plants of the genus Mahonia Nuttall (Berberidaceae) have a long history of medical use in Traditional Chinese Medicine (TCM) for the treatment of a wide range of health disorders, such as tuberculosis, periodontitis, dysentery, pharyngolaryngitis, eczema, and wounds. In the theory of TCM,...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2015.09.013

    authors: He JM,Mu Q

    更新日期:2015-12-04 00:00:00

  • Acute and chronic cannabinoid extracts administration affects motor function in a CREAE model of multiple sclerosis.

    abstract:AIM OF THE STUDY:The multiple sclerosis is an immuno-mediated disorder of the Central Nervous System characterized by inflammatory processes and neurodegenerative changes. It has been shown that the endocannabinoid system is altered in this disease and that the exogenous cannabinoids may play a possible role in its the...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.11.035

    authors: Buccellato E,Carretta D,Utan A,Cavina C,Speroni E,Grassi G,Candeletti S,Romualdi P

    更新日期:2011-02-16 00:00:00

  • Preliminary screening of some tropical plants for anti-tyrosinase activity.

    abstract::In our efforts to find new active tyrosinase inhibitors for skin-whitening or antibrowning preparations, we investigated 67 tropical plants belonging to 38 families, which were evaluated for their anti-tyrosinase activity. The results of our investigation show that extracts of 5 plants, Stryphnodendron barbatimao, Por...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(02)00174-5

    authors: Baurin N,Arnoult E,Scior T,Do QT,Bernard P

    更新日期:2002-10-01 00:00:00

  • In vitro studies on dissolved substance of cinnabar: chemical species and biological properties.

    abstract:UNLABELLED:Cinnabar is one of traditional Chinese medicines widely used in many Asian countries. It is also a medicine with potential toxicity especially when taking overdose. Up to date, studies on the mechanism of the biological activity of cinnabar were still insufficient. AIM OF THE STUDY:To investigate the possib...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.06.018

    authors: Zhou X,Zeng K,Wang Q,Yang X,Wang K

    更新日期:2010-08-19 00:00:00

  • Preventive effect of Abelmoschus manihot (L.) Medik. on bone loss in the ovariectomised rats.

    abstract::Because the biggest culprit in pathogenesis of osteoporosis is oestrogen deficiency, hormone replacement therapy remained the mainstay for prevention. However most of postmenopausal women are more inclined to use natural alternative. We thus investigated the ability of Abelmoschus manihot, a herbal medicine to prevent...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.01.047

    authors: Puel C,Mathey J,Kati-Coulibaly S,Davicco MJ,Lebecque P,Chanteranne B,Horcajada MN,Coxam V

    更新日期:2005-05-13 00:00:00

  • Anna Pavala Sindhooram--an antiatherosclerotic Indian drug.

    abstract::The procedure for the preparation of Anna Pavala Sindhooram (APS), a drug based on the concepts of Indian medicine for the prevention and reversal of the atherosclerotic disease process is described in detail. The uniformity in the composition of samples of the drug obtained in 10 batches, prepared over a period of 5 ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/0378-8741(83)90001-6

    authors: Shanmugasundaram KR,Seethapathy PG,Shanmugasundaram ER

    更新日期:1983-05-01 00:00:00