Pharmacological study of antispasmodic activity of Mirabilis jalapa Linn flowers.

Abstract:

INTRODUCTION:Mirabilis jalapa Linn is a well-studied plant. The indigenous people of Mexico use Mirabilis jalapa to cure many infirmities including dysentery, diarrhea, muscular pain and abdominal colic. In the present investigation, we have further characterized some pharmacological properties of an extract of Mirabilis jalapa flowers; therefore, we intend to contribute to understand the pharmacological effects and clarify the complex use of this medicinal plant. RESULTS:The extract of Mirabilis jalapa (1-1000 mug/mL) exhibits an inhibitory effect (IC(50)=18+/-0.7 micorg/mL) on gut smooth muscle contractility whereas it stimulates the contraction of rabbit aortic muscle (EC(50)=11.60+/-0.26 micorg/mL) in a concentration-dependent manner. CONCLUSIONS:These effects were not due to either ACh or HIS receptors blockage, IP(3), cAMP, cGMP, Ca(2+) release from intracellular storage, or protein kinase mediated contraction-relaxation mechanisms. The effects inducted by the Mirabilis jalapa extract may involve a serotoninergic mechanism, which, in turn, interacts with other adrenergic systems. Further studies are necessary to identify the active compounds within the extract and to elucidate the mechanism of action.

journal_name

J Ethnopharmacol

authors

Aoki K,Cortés AR,Ramírez Mdel C,Gómez-Hernández M,López-Muñoz FJ

doi

10.1016/j.jep.2007.11.004

subject

Has Abstract

pub_date

2008-02-28 00:00:00

pages

96-101

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(07)00594-6

journal_volume

116

pub_type

杂志文章
  • Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro-inflammatory mediators.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The root of Peucedanum japonicum Thunberg is traditionally used to treat coughs, colds, headache and inflammatory diseases in Korea and Japan. Its effects on allergic lung inflammation have not been investigated. AIM OF THE STUDY:To investigate the anti-asthmatic effects of Peucedanum ja...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2017.09.006

    authors: Chun JM,Lee AR,Kim HS,Lee AY,Gu GJ,Moon BC,Kwon BI

    更新日期:2018-01-30 00:00:00

  • Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition.

    abstract:AIM OF STUDY:Adiantum, one of the most widely distributed genera of the family Pteridaceae, is employed in folk medicine worldwide. Adiantum latifolium Lam. has been used in Latin American traditional medicine as anxiolytic, analgesic and antiinflammatory. The present study investigates the antinociceptive and antiinfl...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.05.065

    authors: Nonato FR,Nogueira TM,Barros TA,Lucchese AM,Oliveira CE,Santos RR,Soares MB,Villarreal CF

    更新日期:2011-07-14 00:00:00

  • Microencapsulation enhances the anti-ulcerogenic properties of Entada africana leaf extract.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The antiulcer potentials of most plants still remain largely unexplored, despite their prospects evidenced by their use as ethnomedicine. Entada africana (Mimosaceae) has been widely used in Africa for the treatment of skin infections, wounds, tonic for stomach troubles and against diphth...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.06.012

    authors: Obidike IC,Emeje MO

    更新日期:2011-09-01 00:00:00

  • Isolation and characterization of antimicrobial compounds from Terminalia phanerophlebia Engl. & Diels leaf extracts.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The emergence of drug resistant-tuberculosis and other pathogenic diseases over the past decades, constitutes a serious threat to human health worldwide. According to a 2012 report by the World Health Organization (WHO), South Africa, China, India and Russia are the countries with the hig...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2014.09.003

    authors: Madikizela B,Aderogba MA,Finnie JF,Van Staden J

    更新日期:2014-10-28 00:00:00

  • A Review of the Phytochemical, Pharmacological, Pharmacokinetic, and Toxicological Evaluation of Quercus Infectoria Galls.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Quercus Infectoria galls (QIG) have a long history of use in traditional Chinese medicine and traditional Uyghur medicine for the treatment of diarrhea, hemorrhage, skin disease, and many other human ailments. Medicinal applications of QIG have become increasingly popular in Greece, Asia ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2020.113592

    authors: Elham A,Arken M,Kalimanjan G,Arkin A,Iminjan M

    更新日期:2020-11-17 00:00:00

  • Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Korean red ginseng (KRG) has been shown to possess various biological activities including anti-inflammatory properties. AIM OF THE STUDY:We aimed to investigate the effects and mechanism of KRG on the prevention of atopic dermatitis (AD) using a mouse model. MATERIALS AND METHODS:The e...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2012.11.006

    authors: Cho E,Cho SH

    更新日期:2013-01-09 00:00:00

  • Efficacy of Myrsine africana, Albizia anthelmintica and Hilderbrantia sepalosa herbal remedies against mixed natural sheep helminthosis in Samburu district, Kenya.

    abstract::Traditional livestock healers from Samburu and Turkana communities in Samburu District of Kenya were identified and recruited for participation in this study. Sheep with mixed gastrointestinal helminthosis were purchased from nomadic livestock owners in the area. Three herbal anthelmintic remedies, viz. Myrsine africa...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2003.11.007

    authors: Gathuma JM,Mbaria JM,Wanyama J,Kaburia HF,Mpoke L,Mwangi JN,Samburu and Turkana healers.

    更新日期:2004-03-01 00:00:00

  • Medicinal plants in Baskoure, Kourittenga Province, Burkina Faso: an ethnobotanical study.

    abstract:AIM OF THE STUDY:The majority of people living in Kourittenga Province, Burkina Faso, are highly dependent on medicinal plants for their daily health care. Knowledge on the use of medicinal plants by traditional healers is being seriously threatened, due to the fact that it is commonly transferred from one generation t...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2010.10.010

    authors: Nadembega P,Boussim JI,Nikiema JB,Poli F,Antognoni F

    更新日期:2011-01-27 00:00:00

  • The methanol extract of Spiraea prunifolia var. simpliciflora root inhibits the generation of nitric oxide and superoxide in RAW 264.7 cells.

    abstract::It is well established that nitric oxide (NO) and superoxide radicals play pivotal roles in the pathogenesis of inflammatory diseases and fever. This study is undertaken to address whether the methanol extract of Spiraea prunifolia var. simpliciflora root, a traditional medicine as an antipyretic, modulates the genera...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(99)00101-4

    authors: So HS,Park R,Oh HM,Pae HO,Lee JH,Chai KY,Chung SY,Chung HT

    更新日期:1999-12-15 00:00:00

  • The research progresses and future prospects of Tetrastigma hemsleyanum Diels et Gilg: A valuable Chinese herbal medicine.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Tetrastigma hemsleyanum Diels et Gilg, known as Sanyeqing in China, was an extensively used folk Chinese herbal medicine. This plant had been validated to be highly effective for treating high fever, pneumonia, hepatitis, gastritis, cervicitis, lymphatic tuberculosis, septicemia, and vira...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2021.113836

    authors: Hu W,Zheng Y,Xia P,Liang Z

    更新日期:2021-01-16 00:00:00

  • Linking resource supplies and price drivers: Lessons from Traditional Chinese Medicine (TCM) price volatility and change, 2002-2017.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Worldwide, one of the drivers of substitution and adulteration is the cost of the natural resources (plants, animals, fungi) that are ingredients of traditional medicines. Relatively few studies have been done that link prices of traditional medicine ingredients to what drives changes in ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2018.10.010

    authors: Cunningham AB,Long X

    更新日期:2019-01-30 00:00:00

  • Six weeks oral gavage of a Phyllanthus acidus leaf water extract decreased visceral fat, the serum lipid profile and liver lipid accumulation in middle-aged male rats.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Advancing age is associated with an increased accumulation of visceral fat and liver lipid which is then responsible for an age-related risk for cardiovascular disease. Looking after ourselves well with suitable micronutrients could prevent disease or prolong our healthy cardiovascular fu...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2014.05.039

    authors: Chongsa W,Radenahmad N,Jansakul C

    更新日期:2014-08-08 00:00:00

  • Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Fuling, the sclerotium of Poria cocos, was frequently used in traditional Chinese medicine (TCM) formulae for Alzheimer's disease (AD) intervention over the past 10 centuries. And its extracts exhibited significant effects in both cellular and animal models of AD in previous studies. Howe...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2017.01.007

    authors: Yu M,Xu X,Jiang N,Wei W,Li F,He L,Luo X

    更新日期:2017-02-23 00:00:00

  • β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:The plant Arenaria kansuensis is used in traditional medicine to treat lung inflammation for a long time. However, the anti-pulmonary fibrosis effect and its corresponding bioactive constituents of this plant have not been studied extensively. AIM OF THE STUDY:The purpose of this study w...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112096

    authors: Cui Y,Jiang L,Yu R,Shao Y,Mei L,Tao Y

    更新日期:2019-10-28 00:00:00

  • Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: a review.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Rhizoma alismatis (simplified as RA, "Zexie" in Chinese, ) is a well-known natural medicine with long history in Chinese medicine. As a traditional medicine in China, RA is an important part of many prescriptions and has been commonly used for treating a wide range of ailments related to ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2014.10.061

    authors: Tian T,Chen H,Zhao YY

    更新日期:2014-12-02 00:00:00

  • Anti-inflammatory activity and gastroprotective effect of Hertia cheirifolia L. roots extract.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Hertia cheirifolia L. is used traditionally to treat rheumatic pains and known as a medicinal plant having several pharmaceutical and biological activities. The present study evaluated in vivo the anti-inflammatory and gastroprotective effects of the methanolic extract from H. cheirifolia...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2018.02.010

    authors: Majouli K,Hamdi A,Abdelhamid A,Bouraoui A,Kenani A

    更新日期:2018-05-10 00:00:00

  • Preventive effect of traditional herbal formulae against experimental hypercholesterolemia in rats with special reference to blood lipoprotein cholesterol levels.

    abstract::To investigate the effect of traditional herbal formulae (Zhong Yao) against experimental hypercholesterolemia, we assayed serum lipoprotein levels and hepatic function in rats administered herbal formulae under cholesterol rich diet. Two kinds of herbal formulae; prescription 1 (Bupleurum chinense and other 9 kinds o...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2004.05.009

    authors: Cheng BJ,Moritomo A,Yamasaki Y,Wu LX,Inagaki M,Nishimura M,Tanishima K,Poracova J

    更新日期:2004-10-01 00:00:00

  • Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum.

    abstract:AIM OF THE STUDY:For identification of the active constituents we investigated the anticancer activity of cardenolides from Streptocaulon tomentosum Wight & Arn. (Asclepiadaceae) and from Nerium oleander L. (Apocynaceae) which are both used against cancer in the traditional medicine in their region of origin. MATERIAL...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.01.038

    authors: Rashan LJ,Franke K,Khine MM,Kelter G,Fiebig HH,Neumann J,Wessjohann LA

    更新日期:2011-04-12 00:00:00

  • Metabolites and the pharmacokinetics of kobophenol A from Caragana sinica in rats.

    abstract::This research aims to study the metabolism and pharmacokinetics of phytoestrogen kobophenol A (1), the main active compound of Caragana sinica (Buc'hoz) Rehd. (Fabaceae), in rats. Metabolites of 1 in rats' feces were isolated and purified by multi-chromatograph techniques; three new metabolites of 1, named koboquinone...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2005.05.016

    authors: Liang GL,Bi JB,Huang HQ,Zhang S,Hu CQ

    更新日期:2005-10-03 00:00:00

  • Triterpenoid saponins from Ilex cornuta protect H9c2 cardiomyocytes against H2O2-induced apoptosis by modulating Ezh2 phosphorylation.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ilex cornuta Lindl. et Paxt. (Aquifoliaceae family) belongs to the Ilex genus. The leaves of this plant are used for the popular herbal tea "Ku-Ding-Cha" in China due to their health benefits for sore throat, obesity and hypertension. Our previous studies have shown that the extract of Il...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2020.113691

    authors: Yu D,Zhu Z,Wang M,Ding X,Gui H,Ma J,Yan Y,Li G,Xu Q,Wang W,Mao C

    更新日期:2021-04-06 00:00:00

  • An inventory of the ethnobotanicals used as anthelmintics in the southern Punjab (Pakistan).

    abstract::A survey was conducted in southern Punjab, Pakistan, in order to document existing ethnobotanical knowledge by the herdsmen/key respondents about anthelmintics in ruminants. A 3-satge process was used to document the plants being used to treat and/or control helminthes. This paper describes 29 plants to treat helminth...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.04.015

    authors: Jabbar A,Raza MA,Iqbal Z,Khan MN

    更新日期:2006-11-03 00:00:00

  • The effect of Compound Danshen Dripping Pills, a Chinese herb medicine, on the pharmacokinetics and pharmacodynamics of warfarin in rats.

    abstract:AIM OF THE STUDY:Significant pharmacokinetic/pharmacodynamic (PK/PD) interactions between various herbal products and warfarin have recently been reported. The present study was conducted to determine whether Compound Danshen Dripping Pills (CDDP), a Chinese herb medicine used for the treatment of cardiovascular diseas...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.08.035

    authors: Chu Y,Zhang L,Wang XY,Guo JH,Guo ZX,Ma XH

    更新日期:2011-10-11 00:00:00

  • Anti-inflammatory and wound healing effects of cream containing Curcuma mangga extract.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Curcuma mangga Valeton & Van Zijp. (Zingiberaceae family) contains curcuminoids and diterpenes which have anti-inflammatory effect. In traditional use, the elixir of this plant has been used to detoxify the poisonous plants, treatment of gastric ulcer, chest pain, fever, skin disease and ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.111828

    authors: Srirod S,Tewtrakul S

    更新日期:2019-06-28 00:00:00

  • In vitro anti-proliferative and antioxidant studies on Devil's Club Oplopanax horridus.

    abstract::Devil's Club, Oplopanax horridus (OH), is a widely used folk medicine in Alaska and British Columbia for treating a variety of ailments including arthritis, fever and diabetes. HPLC profiling shows that numerous compounds are present in the 70% ethanolic extract of OH dry root bark powder. OH extract inhibited K562, H...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2006.05.018

    authors: Tai J,Cheung S,Cheah S,Chan E,Hasman D

    更新日期:2006-11-24 00:00:00

  • Antiplasmodial, anti-complement and anti-inflammatory in vitro effects of Biophytum umbraculum Welw. traditionally used against cerebral malaria in Mali.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Biophytum umbraculum Welw. (Oxalidaceae) is a highly valued African medicinal plant used for treatment of cerebral malaria, a critical complication of falciparum malaria. AIM OF THE STUDY:To provide additional information about traditional use of B. umbraculum and to test plant extracts ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2016.05.058

    authors: Austarheim I,Pham AT,Nguyen C,Zou YF,Diallo D,Malterud KE,Wangensteen H

    更新日期:2016-08-22 00:00:00

  • Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis, neuroinflammation, amyloid deposition and cognition impairment in metabolically stressed APPswe/PS1dE9 mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Metabolic syndrome and vascular dysfunction was suggested to be the risk factors for Alzheimer's disease (AD). Xuefu Zhuyu decoction (XZD) is a traditional Chinese medicine used to treat metabolic syndrome and cardiac-cerebral vascular disease. The effects of XZD on ameliorating metabolic...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2017.07.036

    authors: Yeh CW,Liu HK,Lin LC,Liou KT,Huang YC,Lin CH,Tzeng TT,Shie FS,Tsay HJ,Shiao YJ

    更新日期:2017-09-14 00:00:00

  • Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation.

    abstract:AIM OF THE STUDY:Baicalin is an active compound originating from the root of Scutellaria baicalensis Georgi, which has been used for anti-inflammation, anti-bacteria, anti-hypertension, anti-allergy and sedation since ancient China, though the neuronal mechanisms involved in the sedative effect is still unclear. Baical...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2011.03.023

    authors: Chang HH,Yi PL,Cheng CH,Lu CY,Hsiao YT,Tsai YF,Li CL,Chang FC

    更新日期:2011-05-17 00:00:00

  • Integrative serum metabolomics and network analysis on mechanisms exploration of Ling-Gui-Zhu-Gan Decoction on doxorubicin-induced heart failure mice.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Ling-Gui-Zhu-Gan Decoction (LGZGD) formula, derived from traditional Chinese medicine (TCM), has definitive clinical efficacy in the treatment of heart failure (HF) in China. However, little is known of the underlying mechanism of LGZGD. AIM OF THE STUDY:The aim of this work was to inves...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.jep.2019.112397

    authors: Wang X,Gao Y,Tian Y,Liu X,Zhang G,Wang Q,Xie W,Liu K,Qian Q,Wang Q

    更新日期:2020-03-25 00:00:00

  • Ethnobotany and antibacterial activity of some plants used in traditional medicine of Zapotitlán de las Salinas, Puebla (México).

    abstract::The village of Zapotitlán de las Salinas is situated in the Valley of Tehuacán-Cuicatlán, Puebla, Mexico. Plant species used by the local inhabitants to treat gastrointestinal diseases were identified using ethnobotanical, ethnographic and taxonomic methods. Out of 119 interviews, 44 plant species were registered, of ...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章

    doi:10.1016/s0378-8741(03)00213-7

    authors: Hernández T,Canales M,Avila JG,Duran A,Caballero J,Romo de Vivar A,Lira R

    更新日期:2003-10-01 00:00:00

  • Pharmacovigilance practice and risk control of Traditional Chinese Medicine drugs in China: current status and future perspective.

    abstract:ETHNOPHARMACOLOGICAL RELEVANCE:Traditional Chinese Medicine (TCM), including Traditional Chinese Medicine drugs (TCM drugs), has been playing a very important role in health protection and disease control for thousands of years in China. Relying on natural products, mainly of herbal origin, used either as raw materials...

    journal_title:Journal of ethnopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jep.2012.01.058

    authors: Zhang L,Yan J,Liu X,Ye Z,Yang X,Meyboom R,Chan K,Shaw D,Duez P

    更新日期:2012-04-10 00:00:00