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A simple high-performance liquid chromatographic method for the determination of brazilin and its application to a pharmacokinetic study in rats.

Abstract：

ETHNOPHARMACOLOGICAL RELEVANCE:Caesalpinia sappan is a medicinal plant native to China popularly used to treat chronic pelvic inflammation, dysmenorrhea and hysteromyoma. Its main bioactive component is brazilin which had presented antibacterial, anti-inflammatory and anti-platelet aggregation activities. To establish a sensitive, selective, reproducible, and accurate high performance liquid chromatographic (HPLC) method for the quantitative determination of brazilin in plasma, and study the pharmacokinetics of brazilin in rats after intravenous administration of brazilin. MATERIALS AND METHODS:Rats received intravenous injection of 25, 50 and 100mg/kg of brazilin. Concentrations of brazilin in plasma were determined by HPLC method at different time points and all pharmacokinetic parameters were estimated by non-compartmental analysis with WinNonLin 6.2 software. RESULTS:After single intravenous doses of 25, 50 and 100mg/kg brazilin in rats, the main PK parameters were as follows: Cmax were 18.1 ± 4.1, 46.7 ± 8.7 and 82.2 ± 9.6 µg/mL; AUC0-24 were 20.4 ± 4.3, 48.7 ± 6.8 and 90.4 ± 10.3 µgh/mL; and t1/2 were 5.4 ± 1.5, 5.8 ± 0.9 and 6.2 ± 1.2h, respectively. CONCLUSION:It showed that the brazilin was eliminated moderately in rat by intravenous injection route with t1/2 of 6h and showed a dose-dependence profile of Cmax and AUC0-24 at the doses of 25~100mg/kg of brazilin for injection in rats.

journal_name

J Ethnopharmacol

journal_title

Journal of ethnopharmacology

authors

Yan-yan J,Yan L,Ying S,Jinyi Z,Fang D,Yuan S,Ai-dong W

doi

10.1016/j.jep.2013.08.054

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

108-13

issue

1

eissn

0378-8741

issn

1872-7573

pii

S0378-8741(13)00625-9

journal_volume

151

pub_type

杂志文章

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